公开(公告)号：WO2018144620A9

公开(公告)日：2018-08-09

申请号：PCT/US2018/016272

申请日：2018-01-31

申请人： CERTA THERAPEUTICS PTY LTD.

发明人： MILLER, Thomas ,  PAPAIOANNOU, Nikolaos

IPC分类号： C07C235/38 ,  A61K31/167 ,  A61P17/00 ,  C07C235/40 ,  C07C237/20 ,  C07C255/60 ,  C07D205/04 ,  C07D207/12 ,  C07D207/24 ,  C07D209/46 ,  C07D211/22 ,  C07D211/26 ,  C07D211/46 ,  C07D211/58 ,  C07D213/30

摘要： Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein. (Formula (I))