公开(公告)号：WO9315205A3

公开(公告)日：1994-03-03

申请号：PCT/CA9300041

申请日：1993-02-03

Applicant: CONNAUGHT LAB

Inventor： CHONG PELE ,  KANDIL ALI ,  SIA CHARLES ,  KLEIN MICHEL H

IPC: G01N33/53 ,  A61K31/00 ,  A61K39/00 ,  A61K39/102 ,  A61K39/21 ,  A61K39/385 ,  A61K39/39 ,  A61K39/395 ,  A61K47/48 ,  A61P31/00 ,  A61P31/04 ,  A61P37/04 ,  C07H15/04 ,  C07H15/08 ,  C07H15/18 ,  C07H21/04 ,  C07K7/08 ,  C07K14/11 ,  C07K14/16 ,  C07K14/195 ,  C07K14/285 ,  C07K16/00 ,  C12N15/09 ,  C12N15/31 ,  G01N33/569 ,  C07K7/10 ,  C07K15/00 ,  C12N15/63

CPC classification number: C07H15/04 ,  A61K39/00 ,  A61K47/60 ,  A61K47/646 ,  C07H15/08 ,  C07H15/18 ,  C07K14/285 ,  Y02P20/55 ,  Y10S435/851

Abstract: PCT No. PCT/CA93/00041 Sec. 371 Date Oct. 3, 1994 Sec. 102(e) Date Oct. 3, 1994 PCT Filed Feb. 3, 1993 PCT Pub. No. WO93/15205 PCT Pub. Date Aug. 5, 1993The present invention provides immunogenic synthetic peptides which are useful alone or in PRP-conjugates in vaccines against Hemophilus influenza infection. Modifications are possible within the scope of the invention.

公开(公告)号：WO9621465A2

公开(公告)日：1996-07-18

申请号：PCT/CA9600007

申请日：1996-01-05

Applicant: CONNAUGHT LAB ,  YANG YAN PING ,  KANDIL ALI ,  GISONNI LUCY ,  FAHIM RAAFAT E F ,  KLEIN MICHEL H

Inventor： YANG YAN-PING ,  KANDIL ALI ,  GISONNI LUCY ,  FAHIM RAAFAT E F ,  KLEIN MICHEL H

IPC: A61P31/04 ,  C07K14/285 ,  C07K17/10 ,  A61K39/09 ,  A61K39/102 ,  A61K39/385 ,  G01N33/569

CPC classification number: C07K17/10 ,  A61K39/092 ,  A61K2039/55505 ,  A61K2039/6068 ,  C07K14/285 ,  Y10S424/831

Abstract: Immunogenic conjugate molecules comprising at least a portion of a capsular polysaccharide of a Streptococcus strain linked to at least a portion of an outer membrane protein of a Haemophilus strain are provided in which the immunogenicity of the capsular polysaccharide is increased. Particularly capsular polysaccharide from Streptococcus pneumoniae are linked to an outer membrane protein of a Haemophilus influenzae strain, which protein may be the P1, P2 or particularly the P6 outer membrane protein. Conjugate molecules comprising the P6 protein linked to a capsular polysaccharide from an encapsulated pathogen other than Streptococcus are also described, in which the immunogenicity of the capsular polysaccharide is enhanced. Such conjugate molecules may be incorporated into immunogenic compositions for protecting a host against disease caused by the Streptococcus strain and preferably also the Haemophilus strain. The conjugate molecules and antibodies specific for the capsular polysaccharide or specific for the outer membrane protein may be employed in diagnostic procedures and kits. A process for individually isolating P1, P2 and P6 outer membrane proteins from a Haemophilus strain is also provided.

Abstract translation: 提供包含与嗜血杆菌菌株的外膜蛋白的至少一部分连接的链球菌菌株的至少一部分荚膜多糖的免疫原性缀合物分子，其中荚膜多糖的免疫原性增加。 特别是来自肺炎链球菌的荚膜多糖与流感嗜血杆菌菌株的外膜蛋白连接，该蛋白质可以是P1，P2或特别是P6外膜蛋白。 还描述了包含与来自除链球菌以外的包囊病原体的荚膜多糖连接的P6蛋白的缀合物分子，其中荚膜多糖的免疫原性增强。 这样的缀合物分子可以并入免疫原性组合物中，用于保护宿主免受由链球菌菌株引起的疾病，优选还有嗜血杆菌属菌株。 对于荚膜多糖或对外膜蛋白特异的缀合物分子和抗体可用于诊断程序和试剂盒。 还提供了从嗜血杆菌菌株单独分离P1，P2和P6外膜蛋白的方法。