公开(公告)号：WO2022094433A2

公开(公告)日：2022-05-05

申请号：PCT/US2021/057626

申请日：2021-11-01

Applicant: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL

Inventor： BAKALETZ, Lauren O. ,  GOODMAN, Steven D.

IPC: C07K16/12 ,  G01N33/68 ,  A61K39/395 ,  A61L27/54 ,  A61K39/40 ,  A61K39/00 ,  A61P31/04 ,  C07K14/285

Abstract: Provided are methods for one or more of the following: preventing, inhibiting, disrupting, dispersing or treating a polymicrobial biofilm comprising a Haemophilus bacteria in vitro and/or in vivo, such as in a subject in need thereof. The method comprises or consists essentially of, or yet further consists of contacting the polymicrobial biofilm with : (i) an anti DNA binding and bending protein (DNABII) antibody or a biologically active fragment thereof; and (ii) an anti majority subunit (PilA) of type IV pilus (T4P) antibody or a biologically active fragment thereof. Additionally, the methods may further comprise contacting the polymicrobial biofilm with an antibiotic optionally comprising a β-lactam antibiotic or a sulfonamide antibiotic. Also provided are compositions and kits suitable for use in the methods.

公开(公告)号：WO2020157222A1

公开(公告)日：2020-08-06

申请号：PCT/EP2020/052334

申请日：2020-01-30

Applicant: CEVA SANTE ANIMALE S.A.

Inventor： FLORIAN, Volker ,  PIDDE, Heiko ,  STENTZEL, Sebastian ,  DEUTSKENS, Fabian

IPC: A61K39/102 ,  C07K14/285

Abstract: Inactivated ApxIA, ApxIIA and ApxIIIA toxins, vaccines comprising said inactivated toxins and the use thereof for the immunization and protection of mammals are disclosed.

公开(公告)号：WO2020111272A1

公开(公告)日：2020-06-04

申请号：PCT/JP2019/046906

申请日：2019-11-29

Applicant: 旭化成株式会社

Inventor： 宮田　拓治 ,  綾部　雅朗 ,  岡村　哲和

IPC: C07K14/285 ,  C07K14/315 ,  C07K16/12 ,  G01N33/543 ,  G01N33/569

Abstract: 急性副鼻腔炎において、起炎菌を特定するための検出手段の提供。　細菌感染による急性副鼻腔炎の起炎菌であるインフルエンザ菌又は肺炎球菌の検出方法であって、被検体より採取した綿棒に付着した鼻腔ぬぐい液サンプル中の、該起炎菌のリボゾームL7/L12蛋白質の該綿棒当たりの換算質量を、該起炎菌のリボゾームL7/L12蛋白質に特異的に結合し、かつ、該起炎菌を他の細菌と種又は属で識別することができる抗体を用いて、測定し、得られた測定値に基づき起炎菌検出の有無を判断するための判断基準値(カットオフ値)を決定する工程を含む、上記検出方法。

公开(公告)号：WO2012154121A1

公开(公告)日：2012-11-15

申请号：PCT/SE2012/050503

申请日：2012-05-11

Applicant: RIESBECK HEALTHCARE SWEDEN AB ,  RIESBECK, Kristian ,  SU, Yu-Ching

Inventor： RIESBECK, Kristian ,  SU, Yu-Ching

IPC: A61K39/102 ,  A61P31/04 ,  C07K14/285

CPC classification number: A61K39/145 ,  A61K39/0208 ,  A61K39/092 ,  A61K39/102 ,  C07K14/285 ,  C12P21/02

Abstract: A vaccine composition comprising a protein, which can be detected in Haemophilus influenzae , having an amino acid sequence as described in SEQ ID NO: 1, or a fragment thereof, is described. The fragment comprises an amino acid sequence having at least 15 contiguous amino acids from the amino acid sequence of SEQ ID NO: 1, and the fragment (if necessary when coupled to a carrier) is capable of raising an immune response which recognises the polypeptide of SEQ ID NO: 1.

Abstract translation: 描述了包含可在流感嗜血杆菌中检测的具有SEQ ID NO：1所示氨基酸序列的蛋白质或其片段的疫苗组合物。 该片段包含具有SEQ ID NO：1的氨基酸序列的至少15个连续氨基酸的氨基酸序列，并且该片段（如果需要，当与载体偶联时）能够提高识别多肽的免疫应答 SEQ ID NO：1。

公开(公告)号：WO2012139225A1

公开(公告)日：2012-10-18

申请号：PCT/CA2012/050236

申请日：2012-04-12

Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A. ,  BLAIS, Normand ,  LABBE, Steve ,  POOLMAN, Jan

Inventor： BLAIS, Normand ,  LABBE, Steve ,  POOLMAN, Jan

IPC: C07K19/00 ,  A61K39/145 ,  A61K39/385 ,  A61P31/16 ,  A61P37/04 ,  C07K14/285 ,  C12N15/00 ,  C12P21/02

CPC classification number: C07K14/285 ,  A61K39/00 ,  A61K39/0011 ,  A61K39/102 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/40 ,  C07K2319/50 ,  C07K2319/74

Abstract: The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to fusion proteins and immunogenic compositions comprising Protein E and PilA, vaccines comprising such immunogenic compositions and therapeutic uses of the same.

Abstract translation: 本发明涉及包含流感嗜血杆菌蛋白E和Pilin A的组合物。更具体地，本申请涉及包含蛋白E和PilA的融合蛋白和免疫原性组合物，包含这种免疫原性组合物的疫苗及其治疗用途。

公开(公告)号：WO2011056954A3

公开(公告)日：2011-10-20

申请号：PCT/US2010055425

申请日：2010-11-04

Applicant: UNIV MINNESOTA ,  OLIVEIRA SIMONE

Inventor： OLIVEIRA SIMONE

IPC: A61K39/102 ,  C07K14/285 ,  G01N33/569

CPC classification number: C07K14/285 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/522 ,  G01N33/56911 ,  G01N2333/285 ,  G01N2469/20

Abstract: The present invention provides isolated polypeptides having oligopeptide permease activity and an amino acid sequence that has at least 80 % identity with a Haemophilus parasuis OppA polypeptide. Also provided by the present invention are isolated polynucleotides that encode the polypeptides described herein, and antibody that specifically binds a polypeptide described herein. The present invention further provides genetically modified microbes, such as attenuated Haemophilus parasuis strains and other microbes that express polypeptides described herein. Also included are methods for using the polypeptides, polynucleotides, antibody, and genetically modified microbes.

Abstract translation: 本发明提供具有寡肽通透酶活性和与副猪嗜血杆菌OppA多肽具有至少80％同一性的氨基酸序列的分离的多肽。 本发明还提供了编码本文所述多肽的分离的多核苷酸和特异性结合本文所述多肽的抗体。 本发明进一步提供了遗传修饰的微生物，例如减毒副猪嗜血杆菌菌株和表达本文所述多肽的其他微生物。 还包括使用多肽，多核苷酸，抗体和遗传修饰的微生物的方法。

公开(公告)号：WO2011042026A1

公开(公告)日：2011-04-14

申请号：PCT/DK2010/050257

申请日：2010-10-07

Applicant: KØBENHAVNS UNIVERSITET (UNIVERSITY OF COPENHAGEN) ,  BOJESEN, Anders Miki ,  KRISTENSEN, Bodil Marie

Inventor： BOJESEN, Anders Miki ,  KRISTENSEN, Bodil Marie

IPC: C07K14/285 ,  A61K39/102 ,  C07K16/12 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/569

CPC classification number: C07K14/285 ,  A61K39/102 ,  A61K2039/552 ,  C12Q1/689 ,  G01N33/56911

Abstract: The present invention relates to the field of animal health and in particular the causative agent of a new bacterial poultry disease caused by Gallibacteruim spp, including Gallibacterium anatis, Gallibacterium genomospecies 1 and Gallibacterium genomospecies 2. The invention provides a novel RTX toxin from said Gallibacterium species, the novel toxin being named GtxA (Gallibacterium toxin). In addition the invention provides the amino acid and nucleotide sequences of GtxA, a vaccine comprising inactivated toxoid or fragments of the toxoid as well as methods of immunizing birds to prevent said disease and to methods of diagnosing a Gallibacterium anatis infection in birds.

Abstract translation: 本发明涉及动物健康领域，特别是由加利比菌属（Gallibacteruim spp）引起的新型细菌性禽病的致病因素，包括加利福尼亚杆菌属（Galibacterium anatis），基因杆菌属（Galibacterium genomospecies）1和根霉菌属（Gallibacterium genomospecies）2.本发明提供了一种来自所述加利福尼亚菌种的新型RTX毒素 ，这种新型毒素被命名为GtxA（Gallibacterium toxin）。 此外，本发明提供了GtxA的氨基酸和核苷酸序列，其包含灭活的类毒素或类毒素片段的疫苗以及免疫鸟类以预防所述疾病的方法以及诊断鸟类中的阿霉素感染的方法。

公开(公告)号：WO2008085406A3

公开(公告)日：2008-07-17

申请号：PCT/US2007/026153

申请日：2007-12-20

Applicant: NEWPORT LABORATORIES, INC. ,  OLIVEIRA, Simone, R. ,  SIMONSON, Randy, R. ,  MAHLBERG, Jonathan, D. ,  TITUS, Mark, D. ,  OLESON, Tracy, A.

Inventor： OLIVEIRA, Simone, R. ,  SIMONSON, Randy, R. ,  MAHLBERG, Jonathan, D. ,  TITUS, Mark, D. ,  OLESON, Tracy, A.

IPC: A61K39/102 ,  C12N1/36 ,  C07K14/285 ,  C12R1/21

Abstract: The present invention is a culture of cells of Haemophilus parasuis exhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs as a live vaccine. The present invention is also a method of preparing the cell culture, a method of preparing a vaccine from the cell culture, and a live vaccine based on the cell culture. The cell culture was modified from a pathogenic parent strain by MNNG mutagenesis and was selected by complete dependence on streptomycin for growth.

公开(公告)号：WO2007039070A8

公开(公告)日：2008-05-08

申请号：PCT/EP2006009006

申请日：2006-09-15

Applicant: HIPRA LAB SA ,  BENSAID ALBERT ,  PINA PEDRERO SONIA ,  RIVAS ADAN RAQUEL ,  OLIVEIRA SIMONE ,  ESPUNA MASO ENRIC ,  HERRERO MOLINA CARMEN

Inventor： BENSAID ALBERT ,  PINA PEDRERO SONIA ,  RIVAS ADAN RAQUEL ,  OLIVEIRA SIMONE ,  ESPUNA MASO ENRIC ,  HERRERO MOLINA CARMEN

IPC: C07K14/285 ,  A61K39/102 ,  C12N15/11

CPC classification number: C07K14/285 ,  A61K39/00

Abstract: The present invention relates to Haemophilus parasuis polynucleotides produced by recombinant technology. It also relates to polypeptides that are expressed by said polynucleotides and also to a vaccine against H.parasuis that comprises said polypeptides. In another aspect, the invention also relates to the use of polynucleotides to determine if a strain of H. parasuis is virulent or avirulent.

Abstract translation: 本发明涉及通过重组技术产生的嗜血杆菌副嗜血杆菌多核苷酸。 它还涉及由所述多核苷酸表达的多肽，以及涉及包含所述多肽的抗帕桑索的疫苗。 在另一方面，本发明还涉及多核苷酸的用途来确定副猪嗜血菌的毒株是否是有毒的或无毒的。

公开(公告)号：WO2007084053A1

公开(公告)日：2007-07-26

申请号：PCT/SE2007/000034

申请日：2007-01-17

Applicant: FORSGREN, Arne ,  RIESBECK, Kristian

Inventor： FORSGREN, Arne ,  RIESBECK, Kristian

IPC: C07K14/285 ,  A61K39/012 ,  C07K16/12

CPC classification number: A61K39/102 ,  A61K39/00 ,  C07K14/285

Abstract: The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in Haemophilus influenzae, having an amino acid sequence as described in SEQ ID NO 1, an immunogenic fragment of said surface exposed protein, and a recombinant immunogenic protein (pE (A) ) or truncated variants thereof based on said surface exposed protein. Nucleic acid sequences, vaccines, plasmids and phages, non human hosts, recombinant nucleic acid sequences, fusion proteins and fusion products are also described. A method of producing the said protein or truncated fragments thereof recombinantly is also disclosed.

Abstract translation: 本发明涉及可以在流感嗜血杆菌中检测的具有SEQ ID NO：1所示氨基酸序列的表面暴露蛋白质（蛋白质E; pE），所述蛋白质是能够检测到的表达暴露蛋白质的免疫原性片段的毒力因子， 和基于所述表面暴露蛋白的重组免疫原性蛋白（pE（A））或其截短的变体。 还描述了核酸序列，疫苗，质粒和噬菌体，非人宿主，重组核酸序列，融合蛋白和融合产物。 还公开了重组产生所述蛋白质或其截短片段的方法。