公开(公告)号：WO2021007432A1

公开(公告)日：2021-01-14

申请号：PCT/US2020/041407

申请日：2020-07-09

Applicant: COUNTERTRACE LLC

Inventor： HANES, Robert, E. ,  PETTYS, Richard, L. ,  HEADLEY, David, M. ,  HOOPINGARNER, Paul, T. ,  SCHERER, Karen, A.

IPC: C08F20/32 ,  C08F20/52 ,  C08F220/32 ,  C08F220/56 ,  C08G73/02 ,  C08G81/02 ,  C08J3/12 ,  C08L33/06 ,  C08L33/26 ,  C08L79/02

Abstract: Macroparticulates may be formed through at least partial self-assembly by reacting an epoxide-containing (meth)acrylic polymer or copolymer with a compound bearing a nitrogen nucleophile, such as iminodiacetic acid or ethylenediamine. When the epoxide-containing (meth)acrylic polymer or copolymer is formed into a predetermined shape before reaction with the compound bearing the nitrogen nucleophile, a profile of the predetermined shape may be at least partially maintained and undergo expansion in the course of forming the reaction product, thereby producing macroparticulates having a larger volume than the predetermined shape itself. An internal cavity may be formed when generating the macroparticulates in this manner. Optionally, a hexasubstituted benzene or a supramolecular receptor may be adhered to a surface portion of the macroparticulates, either covalently or non-covalently. The compound bearing a nitrogen nucleophile may be further modified to form one or more functionalities capable of binding an analyte. Macroparticulates may be formed through at least partial self-assembly by reacting an epoxide-containing (meth)acrylic polymer or copolymer with a compound bearing a nitrogen nucleophile, such as iminodiacetic acid or ethylenediamine. When the epoxide-containing (meth)acrylic polymer or copolymer is formed into a predetermined shape before reaction with the compound bearing the nitrogen nucleophile, a profile of the predetermined shape may be at least partially maintained and undergo expansion in the course of forming the reaction product, thereby producing macroparticulates having a larger volume than the predetermined shape itself. An internal cavity may be formed when generating the macroparticulates in this manner. Optionally, a hexasubstituted benzene or a supramolecular receptor may be adhered to a surface portion of the macroparticulates, either covalently or non-covalently. The compound bearing a nitrogen nucleophile may be further modified to form one or more functionalities capable of binding an analyte.

公开(公告)号：WO2021050660A1

公开(公告)日：2021-03-18

申请号：PCT/US2020/050096

申请日：2020-09-10

Applicant: COUNTERTRACE LLC

Inventor： HANES, Robert, E., Jr. ,  PETTYS, Richard, L. ,  HEADLEY, David, M. ,  HOOPINGARNER, Paul, T.

IPC: C07C22/04 ,  C07C247/06 ,  B01L3/00 ,  G01N33/53

Abstract: Phenyl rings provide a robust scaffold for molecular design, given the limited number of ring carbon atoms and the fixed geometry in between. However, it can be difficult to form highly substituted phenyl rings suitable for covalent attachment of multiple moieties thereto. Moreover, binding phenyl rings to a surface in a fixed geometry may be difficult. Hexasubstituted benzenes having certain structural features may alleviate the foregoing difficulties by providing versatile groups for further functionalization and surface attachment. Such hexasubstituted benzenes may have a structure of in which each X is independently Cl, Br or N3, and each Z is independently -CH(Br)CH3, -CH(N3)CH3, -CH=CH2, -CH2CH3, -CH2CH2SiR'3 (R'=hydrocarbyl), or. Alternating groups in the hexasubstituted benzenes may be directed toward opposite faces of the phenyl ring, such that orthogonal reactive groups are directed toward the opposite faces, Certain groups may facilitate surface attachment of the hexasubstituted benzenes.