公开(公告)号：WO2021030262A1

公开(公告)日：2021-02-18

申请号：PCT/US2020/045610

申请日：2020-08-10

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： ZHAO, Jian ,  ZHU, Yunfei ,  WANG, Shimiao ,  CHEN, Mi ,  PONTILLO, Joseph

IPC: C07D401/04 ,  C07D401/14 ,  A61K31/4439 ,  A61K31/444 ,  A61P3/10 ,  A61P3/06

Abstract: Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

公开(公告)号：WO2019143718A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/013844

申请日：2019-01-16

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： REDDY, Jayachandra P. ,  MIRMEHRABI, Mahmoud ,  KOTA, Madhukar ,  DASH, Uttam ,  ZHAO, Jian ,  ZHU, Yunfei

IPC: C07D401/04 ,  C07D498/04 ,  C07F5/02

Abstract: Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

公开(公告)号：WO2022261221A1

公开(公告)日：2022-12-15

申请号：PCT/US2022/032691

申请日：2022-06-08

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： STRUTHERS, R. Scott ,  ZHAO, Jian ,  ZHU, Yunfei

IPC: A61K47/54 ,  A61K51/04 ,  A61P35/00 ,  C07D401/14

Abstract: Described herein are non-peptide drug conjugates (NPDCs) that target tumor cells expressing cell surface peptide and protein G protein-coupled receptors and their use in the treatment and/or diagnosis of cancer.

公开(公告)号：WO2021133563A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/064252

申请日：2020-12-10

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： HAN, Sangdon ,  KIM, Sun Hee ,  ZHU, Yunfei

IPC: C07D471/10 ,  C07D471/20 ,  A61K31/444 ,  A61P5/38

Abstract: Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.

公开(公告)号：WO2021091788A1

公开(公告)日：2021-05-14

申请号：PCT/US2020/058202

申请日：2020-10-30

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： HAN, Sangdon ,  KIM, Sun Hee ,  ZHU, Yunfei

IPC: A61K31/506 ,  A61K31/495 ,  A61K31/445 ,  C07D401/04 ,  A61K31/497 ,  A61P5/00

Abstract: Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.

公开(公告)号：WO2017003723A1

公开(公告)日：2017-01-05

申请号：PCT/US2016/038154

申请日：2016-06-17

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： ZHU, Yunfei ,  ZHAO, Jian ,  CHEN, Zhiyong

IPC: C07D471/04 ,  C07D487/04 ,  C07D239/74 ,  A61K31/519 ,  A61K31/517

CPC classification number: C07D471/04

Abstract: Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

Abstract translation: 本文描述的是生长抑素调节剂，制备此类化合物的方法，包含这些化合物的药物组合物和药物的化合物，以及使用这些化合物治疗可能受益于生长抑素活性调节的病症，疾病或病症的方法。

公开(公告)号：WO2022261235A1

公开(公告)日：2022-12-15

申请号：PCT/US2022/032707

申请日：2022-06-08

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： STRUTHERS, R., Scott ,  ZHAO, Jian ,  ZHU, Yunfei

IPC: A61K47/54 ,  A61P35/00 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D487/04

Abstract: Described herein are non-peptide drug conjugates (NPDCs) that target tumor cells expressing cell surface peptide and protein G protein-coupled receptors and their use in the treatment and/or diagnosis of cancer.

公开(公告)号：WO2021126693A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/064493

申请日：2020-12-11

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： HAN, Sangdon ,  KIM, Sun Hee ,  ZHU, Yunfei

IPC: C07D401/10 ,  C07D401/14 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61P3/04 ,  A61P5/38

Abstract: Described herein are compounds that are melanocortin subtype-2 receptor (MC2R) modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of MC2R activity.

公开(公告)号：WO2019157458A1

公开(公告)日：2019-08-15

申请号：PCT/US2019/017529

申请日：2019-02-11

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： ZHAO, Jian ,  WANG, Shimiao ,  ZHU, Yunfei

IPC: C07D401/14 ,  C07D471/04

Abstract: Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

公开(公告)号：WO2019023278A1

公开(公告)日：2019-01-31

申请号：PCT/US2018/043556

申请日：2018-07-24

Applicant: CRINETICS PHARMACEUTICALS, INC.

Inventor： ZHAO, Jian ,  ZHU, Yunfei ,  WANG, Shimiao ,  HAN, Sangdon ,  KIM, Sun Hee

IPC: C07D471/04 ,  A61K31/4375 ,  A61K31/519 ,  A61K31/4985

Abstract: Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.