公开(公告)号：WO2019040992A1

公开(公告)日：2019-03-07

申请号：PCT/AU2018/050941

申请日：2018-08-31

申请人： CURTIN UNIVERSITY

发明人： FALASCA, Marco ,  MASSI, Massimiliano ,  SIMPSON, Peter, Vernon

IPC分类号： C07C233/55 ,  C07C233/27 ,  C07D257/04 ,  C07C255/60 ,  A61K31/41 ,  A61K31/167 ,  A61K31/277 ,  A61P3/10 ,  A61P3/04 ,  A61P9/10

摘要： The invention relates to oleoyl-lysophosphatidylinositol (oleoyl-LPI) and new synthetic derivatives thereof and uses thereof, and to pharmaceutical compositions comprising such compounds. The invention provides activators and/or up-regulators of glucoregulatory hormones such as glucagon like peptide-1 (GLP-1), and more specifically to agonists, partial agonists and reverse antagonists of GPR119 or activatiors of GLP-1 activity and/or synthesis and/or secretion, and pharmaceutical compositions comprising same, uses thereof in therapy of diabetes, obesity and other metabolic disorders.

公开(公告)号：WO2018170553A1

公开(公告)日：2018-09-27

申请号：PCT/AU2018/050267

申请日：2018-03-23

申请人： CURTIN UNIVERSITY OF TECHNOLOGY

发明人： MASSI, Massimiliano ,  SIMPSON, Peter Vernon ,  FALASCA, Marco

IPC分类号： A61K33/24 ,  A61P35/00 ,  C07F13/00 ,  C01G47/00

摘要： This invention provides rhenium tricarbonyl complexes and their use in the treatment of cancer and inhibition of Aurora kinase. The rhenium tricarbonyl complexes comprise a C-donor N-heterocyclic carbene (NHC) ligand. Also provided are processes for the preparation of the rhenium complexes.