公开(公告)号：WO2013133832A3

公开(公告)日：2014-04-03

申请号：PCT/US2012028221

申请日：2012-03-08

Applicant: DANFOSS TURBOCOR COMPRESSORS B V ,  SUN LIN ,  BRASZ JOOST

Inventor： SUN LIN ,  BRASZ JOOST

IPC: F25B13/00

CPC classification number: F25B30/02 ,  F04D17/122 ,  F04D25/06 ,  F04D27/002 ,  F04D27/004 ,  F04D29/048 ,  F04D29/462 ,  F25B1/053 ,  F25B1/10 ,  F25B13/00 ,  F25B41/046 ,  F25B2600/0253 ,  Y02B30/741

Abstract: A heat pump system includes a refrigerant circuit. First and second heat exchangers are arranged in the refrigerant circuit. A flow reversing device selectively changes a direction of flow in the refrigerant circuit between the first and second heat exchangers. A centrifugal compressor is arranged in the fluid circuit and has first and second impellers arranged in series relative to one another to provide a desired compressor pressure ratio. In one example, the centrifugal compressor mounts the first and second impellers on opposing ends of a shaft. The first and second impellers respectively include first and second stage inlets and outlets. One example desired compressor pressure ratio of at least 10:1 corresponds to a second stage outlet pressure to a first stage inlet pressure. A first diffuser is arranged at the first stage outlet, and the first diffuser is a variable geometry diffuser.

Abstract translation: 热泵系统包括制冷剂回路。 第一和第二热交换器布置在制冷剂回路中。 流动反向装置选择性地改变第一和第二热交换器之间的制冷剂回路中的流动方向。 离心压缩机布置在流体回路中，并且具有相对于彼此串联布置的第一和第二叶轮以提供期望的压缩机压力比。 在一个示例中，离心式压缩机将第一和第二叶轮安装在轴的相对端上。 第一和第二叶轮分别包括第一和第二阶段入口和出口。 至少10:1的所需压缩机压力比的一个示例对应于第二级出口压力到第一级入口压力。 第一扩散器布置在第一级出口处，并且第一扩散器是可变几何扩散器。

公开(公告)号：WO2013112122A3

公开(公告)日：2014-06-19

申请号：PCT/US2012022159

申请日：2012-01-23

Applicant: DANFOSS TURBOCOR COMPRESSORS B V ,  SUN LIN ,  BRASZ JOOST ,  RASMUSSEN MOGENS

Inventor： SUN LIN ,  BRASZ JOOST ,  RASMUSSEN MOGENS

IPC: F25B1/04

CPC classification number: F04D17/12 ,  F04D27/0261 ,  F04D29/462 ,  F04D29/464 ,  F05D2250/52 ,  F25B1/00 ,  F25B1/053 ,  F25B1/10 ,  F25B2600/0253 ,  Y02B30/741

Abstract: A refrigeration system includes a chiller having a refrigerant loop. A compressor is part of and in fluid communication with the refrigerant loop. The compressor has two stages, one with a variable geometry diffuser and one with a fixed geometry diffuser.

Abstract translation: 制冷系统包括具有制冷剂回路的冷却器。 压缩机是制冷剂回路的一部分并且与制冷剂回路流体连通。 压缩机有两个阶段，一个具有可变几何扩散器，一个具有固定的几何扩散器。

公开(公告)号：WO2009088968A3

公开(公告)日：2009-10-08

申请号：PCT/US2009000016

申请日：2009-01-05

Applicant: GEN HOSPITAL CORP ,  GETMANOVA ELENA V ,  KOVTUN ALEXANDER ,  SUN LIN ,  FRITSCH EDWARD ,  SEED BRIAN

Inventor： GETMANOVA ELENA V ,  KOVTUN ALEXANDER ,  SUN LIN ,  FRITSCH EDWARD ,  SEED BRIAN

IPC: C07K14/435 ,  C12N9/10

CPC classification number: C12N9/1044

Abstract: Disclosed herein are methods and compositions related to engineered fragments of the human transglutaminase-related protein family, described herein as engineered transglutaminase barrel proteins (ETBPs), that have utility as high affinity, high selectivity target-binding proteins offering advantages as antibody equivalents for therapeutic, analytical, manufacturing and research purposes. ETBPs differ from naturally occurring human transglutaminase fragments by the addition, deletion, replacement and/or substitution of the naturally occurring amino acid sequence. ETBPs can be easily expressed in prokaryotic cells and in many cases can be purified by a simple solubilization and precipitation method.

Abstract translation: 本文公开的是涉及到人的转谷氨酰胺酶相关蛋白家族的工程改造的片段的方法和组合物，本文所述经改造的转谷氨酰胺酶桶蛋白（ETBPs），即具有作为高亲和力，高的选择性靶标结合蛋白提供的优点抗体等同物用于治疗 ，分析，制造和研究目的。 ETBP与天然存在的人转谷氨酰胺酶片段的不同之处在于天然存在的氨基酸序列的添加，缺失，置换和/或取代。 ETBPs可以在原核细胞中容易地表达，并且在许多情况下可以通过简单的溶解和沉淀方法纯化。

公开(公告)号：WO2004101620A3

公开(公告)日：2005-03-31

申请号：PCT/US2004013726

申请日：2004-05-03

Applicant: COMPOUND THERAPEUTICS INC ,  LIPOVSEK DASA ,  SUN LIN ,  KOVTUN ALEXANDER V

Inventor： LIPOVSEK DASA ,  SUN LIN ,  KOVTUN ALEXANDER V

IPC: C07K14/765 ,  C12N15/10

CPC classification number: C07K14/765

Abstract: Disclosed herein are libraries of candidate binding proteins derived from a serum albumin scaffold, from which useful binding proteins may be selected that are specific for known and unknown targets. Also disclosed herein are methods for selection of serum albumin scaffold-based candidate binding proteins which possess such desired binding characteristics.

Abstract translation: 本文公开了源自血清白蛋白支架的候选结合蛋白的文库，可以从其中选择对已知和未知靶特异的有用的结合蛋白。 本文还公开了用于选择具有所需结合特征的基于血清白蛋白支架的候选结合蛋白的方法。