公开(公告)号：WO2022072193A1

公开(公告)日：2022-04-07

申请号：PCT/US2021/051469

申请日：2021-09-22

Applicant: DANISCO US INC

Inventor： BECKER, Nathaniel T. ,  DALE, Douglas A. ,  KAWAKITA, Ryan M. ,  SHER, Herbert B. ,  STROBEL, Scott A. ,  ZICARI, Tina Jeoh

IPC: B01J13/04 ,  B01J13/22 ,  A01N25/28 ,  A23P10/30 ,  A61K8/11 ,  A61K9/48 ,  C11D3/50 ,  B01J13/14

Abstract: Described are compositions and methods relating to a coated granule comprising a core coated with cross-linkable polymer, where the cross-linkable polymer is applied using a feed suspension that includes an acid-neutralized volatile base and a calcium salt insoluble at the pH of the neutralized feed suspension. Volatilization of the base decreases the pH of the feed suspension, thereby solubilizing the calcium salt, and inducing in situ ion-mediated cross-linking of the cross-linkable polymer.