公开(公告)号：WO2022197790A1

公开(公告)日：2022-09-22

申请号：PCT/US2022/020531

申请日：2022-03-16

Applicant: DETECT, INC.

Inventor： GLANTZ, Spencer ,  KEMBLE, Henry ,  HANSEN, William, A. ,  MEYER, Sarai ,  LE, Andrew ,  HENN, Eleanor, Rose ,  GRUN, Molly ,  OVERTON, Maya ,  CHAUDHURY, Rabib, Shahab

IPC: C12Q1/6844 ,  G01N33/543 ,  A61K39/395 ,  C12Q1/6804 ,  B01L7/00

Abstract: Aspects of the disclosure relate to devices and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject, wherein the biological sample is combined with a diluent and/or matrix resolving agent.

公开(公告)号：WO2022076768A1

公开(公告)日：2022-04-14

申请号：PCT/US2021/054085

申请日：2021-10-08

Applicant: DETECT, INC.

Inventor： CORNELL, Amy ,  LEAMON, John, H. ,  ROTHBERG, Jonathan, M. ,  KEMBLE, Henry ,  BALL, James, A.

IPC: G01N33/558 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/531

Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens), and use of a trap region or reagent to reduce the level of one or more target nucleic acid analytes in an amplified sample prior to or in conjunction with detection. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent reduction in the level of one or more target nucleic acid analytes and detection of the amplification products.

公开(公告)号：WO2022011261A2

公开(公告)日：2022-01-13

申请号：PCT/US2021/041088

申请日：2021-07-09

Applicant: DETECT, INC.

Inventor： GLANTZ, Spencer ,  ROTHBERG, Jonathan, M. ,  KEMBLE, Henry ,  SABINA, Jeff ,  JARAMILLO-RIVERI, Sebastian

IPC: C12Q1/6853 ,  C07H21/04 ,  C12Q1/6832 ,  C12Q1/6818 ,  C12Q1/6844 ,  C12Q1/6846 ,  C12Q1/6888 ,  C12Q2600/158

Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent detection of the amplification products.