公开(公告)号：WO2022251325A1

公开(公告)日：2022-12-01

申请号：PCT/US2022/030876

申请日：2022-05-25

Applicant: DIALITY INC.

Inventor： BORILLO, Brandon

IPC: A61M1/16

Abstract: A degassing module that may be used in conjunction with a sorbent regeneration cartridge is described. The degassing module may include an air inlet port, a fluid outlet port, a gas outlet port, first and second channels located in an interior chamber, a port connecting the first and second channels, and a hydrophobic membrane positioned above the second channel. The first channel may be in fluid communication with the air inlet port and the second channel may be in communication with the fluid outlet port. In some embodiments, each of the first and second channels may have a spiral configuration.

公开(公告)号：WO2022256265A1

公开(公告)日：2022-12-08

申请号：PCT/US2022/031448

申请日：2022-05-27

Applicant: DIALITY INC.

Inventor： BORILLO, Brandon ,  POPPE, Clayton

IPC: A61M1/14 ,  A61M1/16 ,  A61M1/28 ,  A61M1/34

Abstract: A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient through the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. Preferably, the hemodialysis system comprises a sorbent filter in the dialysate flow path. Furthermore, the hemodialysis system comprises a dialysate quality sensor disposed directly in the dialysate flow path. The dialysate quality sensor is configured to change color based on a pH level, ammonia level, or ammonium level of the dialysate.

公开(公告)号：WO2022251494A1

公开(公告)日：2022-12-01

申请号：PCT/US2022/031128

申请日：2022-05-26

Applicant: DIALITY INC.

Inventor： BORILLO, Brandon ,  CHEN, Tzu, Tung

IPC: A61M1/14 ,  A61M1/36 ,  B01J20/02 ,  C12N9/14

Abstract: Sorbent regeneration systems for use in dialysis machines are described. Sorbent regeneration cartridges may include a layer of urease, a layer of acid zirconium phosphate, and a layer of sodium zirconium phosphate. An apparatus for conducting dialysis may include a sorbent cartridge, and a dialyzer in fluid communication with the sorbent cartridge, wherein spent dialysate passes from the dialyzer to and through the sorbent cartridge, and wherein the sorbent cartridge comprises a layer of urease, a layer of acid zirconium phosphate, and a layer of sodium zirconium phosphate. The urease may be immobilized to or associated with a carrier.

公开(公告)号：WO2022256269A1

公开(公告)日：2022-12-08

申请号：PCT/US2022/031454

申请日：2022-05-27

Applicant: DIALITY INC.

Inventor： BORILLO, Brandon ,  POPPE, Clayton

IPC: A61M1/14 ,  A61M1/34 ,  A61M1/16 ,  C01C1/02 ,  C01D13/00

Abstract: A portable hemodialysis system is provided comprising a dialyzer, having a dialysate- replenishing system for replenishing minerals of dialysate in the dialyzer, the dialysate- replenishing system includes: a sorbent filter configured to remove ammonia from the dialysate, the sorbent filter having an outlet that outputs the dialysate to a dialysate flow path; a first reagent source containing a first reagent solution; a first pump configured to inject the first reagent solution into the dialysate flow path; a first mixer coupled to the dialysate flow path and downstream of the first pump, the first mixer configured to mix the dialysate with the first reagent solution; a conductivity sensor configured to measure a level of dissolved solids in the dialysate after the first mixer; and a controller configured to adjust a flow rate of the first reagent solution by adjusting the first pump based at least on the level of measured levels.