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公开(公告)号：WO2022251325A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/030876
申请日：2022-05-25
Applicant: DIALITY INC.
Inventor： BORILLO, Brandon
IPC: A61M1/16
Abstract: A degassing module that may be used in conjunction with a sorbent regeneration cartridge is described. The degassing module may include an air inlet port, a fluid outlet port, a gas outlet port, first and second channels located in an interior chamber, a port connecting the first and second channels, and a hydrophobic membrane positioned above the second channel. The first channel may be in fluid communication with the air inlet port and the second channel may be in communication with the fluid outlet port. In some embodiments, each of the first and second channels may have a spiral configuration.
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公开(公告)号：WO2021091770A1
公开(公告)日：2021-05-14
申请号：PCT/US2020/058030
申请日：2020-10-29
Applicant: DIALITY INC.
Inventor： MITROVIC, Miroslav , DANDLER, Andres
Abstract: A connector for use with a dialyzer to connect a conduit from a dialyzer with a conduit from a dialysate source. The connector includes a sleeve (female component) and a collet (male component). The sleeve has a generally cylindrical shape with an opening at one end having a circular shape with at least one slot positioned along the periphery of the circular shape. The sleeve also includes at least one flexible finger having a barb at a free end. The collet is configured to be housed within an interior chamber of the sleeve and has first and second gaps to house the barbs and first and second deflectable flanges to lock into recesses in a conduit.
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公开(公告)号：WO2022256265A1
公开(公告)日：2022-12-08
申请号：PCT/US2022/031448
申请日：2022-05-27
Applicant: DIALITY INC.
Inventor： BORILLO, Brandon , POPPE, Clayton
Abstract: A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient through the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. Preferably, the hemodialysis system comprises a sorbent filter in the dialysate flow path. Furthermore, the hemodialysis system comprises a dialysate quality sensor disposed directly in the dialysate flow path. The dialysate quality sensor is configured to change color based on a pH level, ammonia level, or ammonium level of the dialysate.
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公开(公告)号：WO2020086540A1
公开(公告)日：2020-04-30
申请号：PCT/US2019/057373
申请日：2019-10-22
Applicant: DIALITY INC.
Inventor： KHAWAR, Osman , POPPE, Clayton
Abstract: A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient to the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. In addition, the hemodialysis system includes two reservoirs which can be alternately placed in the dialysis flow path using various controllable fluid valves. The hemodialysis system may include a sorbent filter in the dialysate flow path which filters used dialysate. Alternatively, the filter may be positioned within a separate closed loop filter flow path which is isolated from the blood flow path and dialysate flow path. For this embodiment, the hemodialysis system includes additional controllable fluid valves which selectively connect the filter flow path to the reservoir which is not currently providing dialysis treatment to a patient.
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公开(公告)号：WO2022251494A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/031128
申请日：2022-05-26
Applicant: DIALITY INC.
Inventor： BORILLO, Brandon , CHEN, Tzu, Tung
Abstract: Sorbent regeneration systems for use in dialysis machines are described. Sorbent regeneration cartridges may include a layer of urease, a layer of acid zirconium phosphate, and a layer of sodium zirconium phosphate. An apparatus for conducting dialysis may include a sorbent cartridge, and a dialyzer in fluid communication with the sorbent cartridge, wherein spent dialysate passes from the dialyzer to and through the sorbent cartridge, and wherein the sorbent cartridge comprises a layer of urease, a layer of acid zirconium phosphate, and a layer of sodium zirconium phosphate. The urease may be immobilized to or associated with a carrier.
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Patent Agency Ranking
公开(公告)号：WO2021091915A1
公开(公告)日：2021-05-14
申请号：PCT/US2020/058731
申请日：2020-11-03
Applicant: DIALITY INC.
Inventor： DANDLER, Andres , POPPE, Clayton , MITROVIC, Miroslav
Abstract: Disclosed are example embodiments of a dialysis machine having a frame, a cartridge cassette, one or more alignment-locking features, and an actuation mechanism. The frame is fixedly coupled to the dialysis machine, and the cassette is slidably coupled to the frame. The cassette can have one or more track structures, with each of the one or more track structures having a rotor and one or more rollers. The one or more alignment-locking features extend from the frame and are configured to be inserted into one or more alignment features of a disposable cartridge that functions to secure or release the disposable cartridge. The actuation mechanism is made to slide the cassette with respect to the one or more track structures.
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公开(公告)号：WO2021091767A1
公开(公告)日：2021-05-14
申请号：PCT/US2020/057995
申请日：2020-10-29
Applicant: DIALITY INC.
Inventor： MITROVIC, Miroslav , DANDLER, Andres , POPPE, Clayton , BOYLE, Dylan
Abstract: A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient to the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. In addition, the hemodialysis system includes two reservoirs which can be alternately placed in the dialysis flow path using various controllable fluid valves. The weight, and therefore the level of dialysate, of each reservoir is measured by a preferred level sensor having a lever arm, a load cell, and a tilt sensor. The load cell and tilt sensor are electrically connected to a processor for sending force and tilt measurements to the processor. The processor may analyze the tilt measurements to correct for any inaccurate measurements of the load cell caused by the tilt.
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公开(公告)号：WO2022256269A1
公开(公告)日：2022-12-08
申请号：PCT/US2022/031454
申请日：2022-05-27
Applicant: DIALITY INC.
Inventor： BORILLO, Brandon , POPPE, Clayton
Abstract: A portable hemodialysis system is provided comprising a dialyzer, having a dialysate- replenishing system for replenishing minerals of dialysate in the dialyzer, the dialysate- replenishing system includes: a sorbent filter configured to remove ammonia from the dialysate, the sorbent filter having an outlet that outputs the dialysate to a dialysate flow path; a first reagent source containing a first reagent solution; a first pump configured to inject the first reagent solution into the dialysate flow path; a first mixer coupled to the dialysate flow path and downstream of the first pump, the first mixer configured to mix the dialysate with the first reagent solution; a conductivity sensor configured to measure a level of dissolved solids in the dialysate after the first mixer; and a controller configured to adjust a flow rate of the first reagent solution by adjusting the first pump based at least on the level of measured levels.
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公开(公告)号：WO2021091912A1
公开(公告)日：2021-05-14
申请号：PCT/US2020/058727
申请日：2020-11-03
Applicant: DIALITY INC.
Inventor： POPPE, Clayton , SANTIAGO, Ronaldo , BEU, Scott
IPC: A61M5/145
Abstract: A syringe pump to deliver heparin to into the blood circuit of a hemodialysis system. The syringe pump is configured to receive a syringe having a plunger movable within a lumen of an elongate tubular member. The syringe pump may include a housing having a recess configured to receive at least a portion of the syringe, a drive mechanism for moving the plunger within the lumen, the drive mechanism comprising a motor and a lead screw; and a grabber mechanism. The grabber mechanism includes a control arm, back panel, and upper and lower control fingers, the control fingers each have first and second ends, and a curved portion therebetween having a width, an interior edge, and an exterior edge, wherein the first ends of the upper and lower control fingers are coupled to the control arm via first and second spring hinges.
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公开(公告)号：WO2021091794A1
公开(公告)日：2021-05-14
申请号：PCT/US2020/058342
申请日：2020-10-30
Applicant: DIALITY INC.
Inventor： POPPE, Clayton , KHAWAR, Osman
Abstract: A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient, to the dialyzer, and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. The hemodialysis system includes a hemodialysis machine and dialysate generator which are physically connectable to, and disconnectable from, one another. To connect the hemodialysis machine and dialysate generator together, both the hemodialysis machine and dialysate generator possess connectable and disconnectable electrical connectors and fluid connectors which are positioned and constructed to allow both a fluid and electrical connection between the two machines. The hemodialysis machine includes a processor and a user interface, preferably in the form of a touchscreen, that is capable of controlling both the functions of the hemodialysis machine and the dialysate generator.
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