公开(公告)号：WO2016199020A1

公开(公告)日：2016-12-15

申请号：PCT/IB2016/053339

申请日：2016-06-08

Applicant: DR. REDDY'S LABORATORIES LIMITED

Inventor： MURKI, Veerender ,  VASAM, Sridhar ,  KOMATI, Shravan Kumar ,  GUNDA, Nageshwar ,  BADISA, Venkata Rao ,  R, V Ramana Rao ,  ORUGANTI, Srinivas ,  GANORKAR, Rakesh ,  DAHANUKAR, Vilas Hareshwar ,  KATKAM, Srinivas ,  THATIPALLI, Poornachander

IPC: C07D239/42

CPC classification number: C07D239/42

Abstract: The present application relates to a process for preparation of ceritinib and intermediates thereof. Specifically, the present application relates to a process for preparation of N-(4-(1-benzyl- 1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)acetamide (VC) comprising treating N-(4-(bromomethyl)-2-isopropoxy-5-methylphenyl)acetamide (IIID) with 1- benzylpiperidin-4-one (IVA). The present application also relates to a process for conversion of N-(4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)-acetamide (VC) to ceritinib or an acid-addition salt thereof.

Abstract translation: 本申请涉及制备硫酸尼他菌及其中间体的方法。 具体地说，本申请涉及制备N-（4-（1-苄基-1,2,3,6-四氢吡啶-4-基）-2-异丙氧基-5-甲基苯基）乙酰胺（VC）的方法，包括 用1-苄基哌啶-4-酮（IVA）处理N-（4-（溴甲基）-2-异丙氧基-5-甲基苯基）乙酰胺（IIID）。 本申请还涉及将N-（4-（1-苄基-1,2,3,6-四氢吡啶-4-基）-2-异丙氧基-5-甲基苯基） - 乙酰胺（VC）转化为 塞立替尼或其酸加成盐。

公开(公告)号：WO2014083512A1

公开(公告)日：2014-06-05

申请号：PCT/IB2013/060441

申请日：2013-11-27

Applicant: DR. REDDY'S LABORATORIES LIMITED

Inventor： DAHANUKAR, Vilas Hareshwar ,  GILLA, Goverdhan ,  KUNHIMON, Syam Kumar Unniaran ,  GUNDA, Nageshwar ,  BADISA, Venkata Rao ,  KOMATI, Shravankumar ,  BENDA, Srinivas ,  MAHAPATRA, Tridib

IPC: C07J43/00 ,  C07J13/00 ,  C07J41/00

CPC classification number: C07J43/003 ,  C07J1/0011 ,  C07J13/002 ,  C07J13/005 ,  C07J41/0005

Abstract: The present invention relates to process for the preparation of abiraterone acetate, its salts and intermediates thereof, crystalline forms of abiraterone acetate salts and purification of abiraterone acetate.

Abstract translation: 本发明涉及醋酸阿比酮酮及其盐和中间体的制备方法，醋酸阿比特罗酮的结晶形式和醋酸阿的酮的纯化。