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公开(公告)号：WO2022208550A1
公开(公告)日：2022-10-06
申请号：PCT/IN2022/050322
申请日：2022-03-31
Applicant: DR. REDDY'S LABORATORIES LIMITED
Inventor： KANDULA, Rama Bhupal Reddy , BANDYOPADHYAY, Suman , CHANDRAWANSHI, Vikas , VEERAMALLY, Sampath kumar , POLISHETTY, Raghavendra , BS, Megha
Abstract: The present invention discloses a cell culture method for producing a CTLA-4 fusion protein composition comprising a target % of monomer species of the fusion protein, wherein the cell culture method comprises addition of cysteine in the cell culture medium. The invention further discloses a cell culture process to produce CTLA-4 fusion protein composition with target % of monomer species involving a dual temperature shift with addition of cysteine. Also, the present invention provides a CTLA-4 fusion protein composition comprised of target % of monomer species and/or homodimer species of the CTLA-4 fusion protein.
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公开(公告)号：WO2022162704A1
公开(公告)日：2022-08-04
申请号：PCT/IN2022/050083
申请日：2022-02-01
Applicant: DR. REDDY'S LABORATORIES LIMITED
Inventor： SAIDARAO, Korampalli , AAMUDALAPALLI, Haribabu , RAGHUPROLU, Sharath Chandra , PANDURANGAN, Pandiaraja , HALDAR, Suranjana , MANDAL, Samir Kumar
Abstract: The present invention discloses a therapeutic composition comprising fusion protein with reduced heterogeneity in the glycosylation profile of the protein and methods thereof. More particularly the invention provides the composition with reduced heterogeneity in the glycosylation profile. By reducing heterogeneity, the resultant preparation is expected to exhibit superior, consistent results in terms of safety, purity and potency. The invention is of particular importance as it can form the part of the critical quality attributes (CQA) that help in ensuring batch-to-batch consistency and predicted shelf-life of complex protein molecules.
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公开(公告)号：WO2022157806A1
公开(公告)日：2022-07-28
申请号：PCT/IN2022/050044
申请日：2022-01-20
Applicant: DR. REDDY'S LABORATORIES LIMITED
Abstract: The present invention discloses an optimal lyophilization method to prepare a room-temperature-stable freeze-dried formulation of an anti-α4β7 antibody wherein the lyophilized anti-α4β7 antibody formulation obtained from the said method exhibits stability at room temperature for at least three months and reconstituted anti-α4β7 antibody formulation exhibits stability at room temperature at least for 24 hours.
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公开(公告)号：WO2020165807A1
公开(公告)日：2020-08-20
申请号：PCT/IB2020/051164
申请日：2020-02-13
Applicant: DR. REDDY'S LABORATORIES LIMITED
Abstract: The present invention provides co-crystals of Deutetrabenazine and Vanillin, process for the preparation of co-crystals and pharmaceutical composition comprising said co-crystals of Deutetrabenazine. The co-crystals of Deutetrabenazine and Vanillin is non-hygroscopic, chemically and physically stable and suitable for pharmaceutical formulation and its use in the treatment of tardive dyskinesia and chorea associated with Huntington's disease.
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公开(公告)号：WO2019092625A1
公开(公告)日：2019-05-16
申请号：PCT/IB2018/058770
申请日：2018-11-08
Applicant: DR. REDDY'S LABORATORIES LIMITED
Inventor： ARKALA, Anil Kumar Reddy , BHALERAO, Dinesh , MAHAPATRA, Tridib , MOVVA, Venkateswarlu , JINNA, Rajendar Reddy , ELATI, Raviram Chandrasekhar
IPC: C07D213/73 , C07D215/00 , A61K31/00
Abstract: The present invention provides a process for the preparation of Lenvatinib or its salts thereof. The present invention also provides a crystalline form of Lenvatinib, which is characterized by the PXRD pattern as shown in figure 1. The present invention also provides a process for their preparation and pharmaceutical composition thereof.
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Patent Agency Ranking
公开(公告)号：WO2018007927A1
公开(公告)日：2018-01-11
申请号：PCT/IB2017/054000
申请日：2017-07-03
Applicant: DR. REDDY'S LABORATORIES LIMITED
Inventor： MURUGAN, Andiappan , KABRA, Vipinkumar Shriram , GADE, Chinna Saida Reddy , GONDU, Rama Rao , CHANDRASHEKAR, Shravankumar , PASUPATHY, Krishnamoorthy , KALAISELVAN, Anandan
IPC: C07D471/04
CPC classification number: C07D471/04 , C07B49/00 , C07B2200/13
Abstract: The present application relates to a process for the preparation of crystalline form A of palbociclib having specific surface area more than 2m 2 /g comprising one-pot process for the preparation of compound of formula (IV). The present application further relates to the preparation of acid-addition salts of palbociclib and their use for the synthesis of crystalline form A of palbociclib having specific surface area more than 2 m 2 /g.
Abstract translation: 本申请涉及制备比表面积大于2m 2 / g的palbociclib的结晶形式A的方法，包括一锅法用于制备 式（IV）的化合物。 本申请进一步涉及palbociclib的酸加成盐的制备及其用于合成比比表面积大于2m 2 / g的palbociclib的结晶形式A的用途。
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公开(公告)号：WO2017203474A1
公开(公告)日：2017-11-30
申请号：PCT/IB2017/053105
申请日：2017-05-26
Applicant: DR. REDDY'S LABORATORIES LIMITED
Inventor： DAHANUKAR, Vilas Hareshwar , ELATI, Raviram Chandrasekhar , AALLA, Sampath , KURELLA, Sreenivasulu , MAMIDIPALLI, Phani , ADLA, Vijay , VARANASI, Ganesh
IPC: C07C233/47
CPC classification number: C07C233/47 , C07C269/06 , C07D203/20 , C07F7/1804 , C07C271/16
Abstract: The present application relates to a process for preparation of tert-butyl ( R )-(1-([1,1'-biphenyl]-4- yl)-3-hydroxypropan-2-yl)carbamate (IA). The compound of formula (IA) may be used as an intermediate for the preparation of sacubitril.
Abstract translation: 本发明涉及制备（R） - （1 - （[1,1'-联苯] -4-基） - 3-羟基丙-2-基）氨基甲酸叔丁酯（IA）。 式（IA）的化合物可以用作制备沙丙麦胺的中间体。
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公开(公告)号：WO2016009401A2
公开(公告)日：2016-01-21
申请号：PCT/IB2015/055428
申请日：2015-07-17
Applicant: DR. REDDY'S LABORATORIES LIMITED
Inventor： SUD, Abhishek , CHAUDHARI, Pramod , BANDICHHOR, Rakeshwar , DAHANUKAR, Vilas Hareshwar , CHEEMALAPATI, Venkata Annapurna Sasi Kala , KAVITAPU, Dasameswara Rao , LILAKAR, Jaydeepkumar Dahyabhai
CPC classification number: C07F9/65583
Abstract: The present application relates to processes for the preparation of tedizolid phosphate.
Abstract translation: 本申请涉及用于制备磷酸三（2-乙基己基）酯的方法。
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公开(公告)号：WO2016001851A1
公开(公告)日：2016-01-07
申请号：PCT/IB2015/054947
申请日：2015-07-01
Applicant: DR. REDDY'S LABORATORIES LIMITED
Inventor： DAHANUKAR, Vilas , ELATI, Ravi Ram Chandrasekhar , ORUGANTI, Srinivas , RAPOLU, Rajesh Kumar , KURELLA, Sreenivasulu
IPC: C07D487/04 , C07D239/47
CPC classification number: C07D487/04 , C07D239/48 , C07D405/12
Abstract: The present application relate to processes for preparing Ticagrelor and to intermediates that are useful in the processes.
Abstract translation: 本申请涉及制备替卡格雷和在该方法中有用的中间体的方法。
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公开(公告)号：WO2014188353A3
公开(公告)日：2014-11-27
申请号：PCT/IB2014/061590
申请日：2014-05-21
Applicant: DR. REDDY'S LABORATORIES LIMITED
Inventor： FRYSZKOWSKA, Anna , QUIRMBACH, Michael Siegfried , GORANTLA, Srikanth Sarat Chandra , ALIETI, Sanjay Reddy , POREDDY, Srinivas Reddy , DINNE, Naresh Kumar Reddy , TIMMANNA, Upadhya , DAHANUKAR, Vilas
Abstract: The present application relates to a regioselective and stereoselective processes for the preparation of dehydroepiandrosterone (DHEA) and processes for its intermediates.
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