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公开(公告)号：WO2019026014A1
公开(公告)日：2019-02-07
申请号：PCT/IB2018/055801
申请日：2018-08-02
发明人： ACHANTA, Srinivas , CHAKKA, Ramesh , DAHANUKAR, Vilas Hareshwar , CHANDRASEKHAR, Elati Ravi Rama , BHIMAVARAPU, Srinivasa Reddy , MADARABOINA, Mahendar
IPC分类号： C07D405/06
CPC分类号： C07D405/06
摘要： The present invention provides process for preparation of lifitegrast, amine salts of lifitegrast, process for preparation of amine salts of lifitegrast and their use in purification of lifitegrast, and also provided are process for preparation of amorphous lifitegrast and pharmaceutical compositions comprising lifitegrast prepared by the processes of the present invention.
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公开(公告)号：WO2017203459A1
公开(公告)日：2017-11-30
申请号：PCT/IB2017/053082
申请日：2017-05-25
发明人： SAI, Sudhir , BASU, Debjit , SARVESH, Kumar , NEELAM, Uday Kumar , MANDAL, Amit Kumar , BANDICHHOR, Rakeshwar , DAHANUKAR, Vilas Hareshwar
IPC分类号： C07D519/00
摘要： The present application relate to a process for preparation of 4-Methylene tetrahydrofuran compound of formula II, which is useful as an intermediate for the preparation of halichondrin B analogues such as Eribulin.
摘要翻译： 本申请涉及制备式II的4-亚甲基四氢呋喃化合物的方法，其可用作制备软海绵素B类似物例如艾日布林的中间体。
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公开(公告)号：WO2017064627A2
公开(公告)日：2017-04-20
申请号：PCT/IB2016/056097
申请日：2016-10-12
发明人： WARREN, Sarah Ann , FOX, Martin Edward , MEEK, Graham Andrew , CARLONE, Armando , BERNARDI, Luca , DE KONING, Pieter David , PETERSON, Justine Ann , COZZI, Pier Giorgio , BASU, Debjit , SAI, Sudhir , SARVESH, Kumar , MANDAL, Amit Kumar , BANDICHHOR, Rakeshwar , DAHANUKAR, Vilas Hareshwar , DAVIDSON, Robert Wen Ming
IPC分类号： A61K31/00
CPC分类号： A61K31/00
摘要： The present application provides process for preparation of 4-Methylene tetrahydrofuran compound of formula II, which is useful as an intermediate for the preparation of halichondrin B analogues such as Eribulin.
摘要翻译： 本申请提供了用于制备式II的4-亚甲基四氢呋喃化合物的方法，其可用作制备软海绵素B类似物例如艾日布林的中间体。
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公开(公告)号：WO2013144857A1
公开(公告)日：2013-10-03
申请号：PCT/IB2013/052428
申请日：2013-03-27
发明人： DAHANUKAR, Vilas Hareshwar , KUNHIMON, Syam Kumar Unniaran , TIMMANA, Upadhya , PAL, Abir Kumar , MACHA, Mahendar , MEESALA, Venkata Madhubabu , THALABATHULA, Krishna Mohan
IPC分类号： C07D311/76 , C07C57/38 , C07C39/15
CPC分类号： C07D311/04 , C07C51/09 , C07C59/52 , C07C211/27 , C07D311/16 , C07D311/20 , C07C59/48
摘要： The present application relates to an improved process for the preparation of (S)- equol (1). The present application also relates to novel intermediates of formula (7), (7A), (8) and (9) and their use for the synthesis of (S)-equol.
摘要翻译： 本申请涉及制备（S） - 雌马酚（1）的改进方法。 本申请还涉及式（7），（7A），（8）和（9）的新型中间体及其用于合成（S） - 均酚的用途。
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公开(公告)号：WO2017203474A1
公开(公告)日：2017-11-30
申请号：PCT/IB2017/053105
申请日：2017-05-26
发明人： DAHANUKAR, Vilas Hareshwar , ELATI, Raviram Chandrasekhar , AALLA, Sampath , KURELLA, Sreenivasulu , MAMIDIPALLI, Phani , ADLA, Vijay , VARANASI, Ganesh
IPC分类号： C07C233/47
CPC分类号： C07C233/47 , C07C269/06 , C07D203/20 , C07F7/1804 , C07C271/16
摘要： The present application relates to a process for preparation of tert-butyl ( R )-(1-([1,1'-biphenyl]-4- yl)-3-hydroxypropan-2-yl)carbamate (IA). The compound of formula (IA) may be used as an intermediate for the preparation of sacubitril.
摘要翻译： 本发明涉及制备（R） - （1 - （[1,1'-联苯] -4-基） - 3-羟基丙-2-基）氨基甲酸叔丁酯（IA）。 式（IA）的化合物可以用作制备沙丙麦胺的中间体。
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公开(公告)号：WO2016009401A2
公开(公告)日：2016-01-21
申请号：PCT/IB2015/055428
申请日：2015-07-17
发明人： SUD, Abhishek , CHAUDHARI, Pramod , BANDICHHOR, Rakeshwar , DAHANUKAR, Vilas Hareshwar , CHEEMALAPATI, Venkata Annapurna Sasi Kala , KAVITAPU, Dasameswara Rao , LILAKAR, Jaydeepkumar Dahyabhai
CPC分类号： C07F9/65583
摘要： The present application relates to processes for the preparation of tedizolid phosphate.
摘要翻译： 本申请涉及用于制备磷酸三（2-乙基己基）酯的方法。
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公开(公告)号：WO2012172564A1
公开(公告)日：2012-12-20
申请号：PCT/IN2012/000366
申请日：2012-05-24
申请人： DR. REDDY'S LABORATORIES LIMITED , DAHANUKAR, Vilas Hareshwar , AMBHAIKAR, Narendra Bhalchandra , VADALI, Ravi kumar , MERUVA, Suresh babu , MANIKONDA, Swapna , KAMARAJU, Raghavendra Rao , TIMMANNA, Upadhya , MOHAMMED, Aaseef , PULIPATI, Ranga Prasad , MOHAMMED, Yakub Iqbal
发明人： DAHANUKAR, Vilas Hareshwar , AMBHAIKAR, Narendra Bhalchandra , VADALI, Ravi kumar , MERUVA, Suresh babu , MANIKONDA, Swapna , KAMARAJU, Raghavendra Rao , TIMMANNA, Upadhya , MOHAMMED, Aaseef , PULIPATI, Ranga Prasad , MOHAMMED, Yakub Iqbal
IPC分类号： C07D239/42 , C07D239/22 , C07D239/36 , C07D405/06
CPC分类号： C07D239/42 , C07D239/36 , C07D407/06
摘要： Disclosed is the process for the preparation of 4-(fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-5-formyl-pyrimidine of formula (I), which is the intermediate of rosuvastatin calcium. Purification of substantially pure acetonide protected tert-butyl ester of rosuvastatin (II) and its use for the preparation of substantially pure amorphous rosuvastatin calcium are also disclosed.
摘要翻译： 公开了制备式（I）的4-（氟苯基）-6-异丙基-2-（N-甲基-N-甲磺酰氨基）-5-甲酰基 - 嘧啶的方法，其是瑞舒伐他汀钙的中间体。 还公开了基本上纯的丙酮化合物保护的瑞舒伐他汀（II）的叔丁酯及其用于制备基本上纯的无定形罗苏伐他汀钙的用途。
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公开(公告)号：WO2016199020A1
公开(公告)日：2016-12-15
申请号：PCT/IB2016/053339
申请日：2016-06-08
发明人： MURKI, Veerender , VASAM, Sridhar , KOMATI, Shravan Kumar , GUNDA, Nageshwar , BADISA, Venkata Rao , R, V Ramana Rao , ORUGANTI, Srinivas , GANORKAR, Rakesh , DAHANUKAR, Vilas Hareshwar , KATKAM, Srinivas , THATIPALLI, Poornachander
IPC分类号： C07D239/42
CPC分类号： C07D239/42
摘要： The present application relates to a process for preparation of ceritinib and intermediates thereof. Specifically, the present application relates to a process for preparation of N-(4-(1-benzyl- 1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)acetamide (VC) comprising treating N-(4-(bromomethyl)-2-isopropoxy-5-methylphenyl)acetamide (IIID) with 1- benzylpiperidin-4-one (IVA). The present application also relates to a process for conversion of N-(4-(1-benzyl-1,2,3,6-tetrahydropyridin-4-yl)-2-isopropoxy-5-methylphenyl)-acetamide (VC) to ceritinib or an acid-addition salt thereof.
摘要翻译： 本申请涉及制备硫酸尼他菌及其中间体的方法。 具体地说，本申请涉及制备N-（4-（1-苄基-1,2,3,6-四氢吡啶-4-基）-2-异丙氧基-5-甲基苯基）乙酰胺（VC）的方法，包括 用1-苄基哌啶-4-酮（IVA）处理N-（4-（溴甲基）-2-异丙氧基-5-甲基苯基）乙酰胺（IIID）。 本申请还涉及将N-（4-（1-苄基-1,2,3,6-四氢吡啶-4-基）-2-异丙氧基-5-甲基苯基） - 乙酰胺（VC）转化为 塞立替尼或其酸加成盐。
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公开(公告)号：WO2013150495A2
公开(公告)日：2013-10-10
申请号：PCT/IB2013/052733
申请日：2013-04-05
发明人： DAHANUKAR, Vilas Hareshwar , GILLA, Goverdhan , KURELLA, Sreenivasulu , KULKARNI, Shweta Mahajan , ANUMULA, Raghupathi Reddy , AALLA, Sampath , BOJJA, Yakambram , ELATI, Ravi Ram Chandra Sekhar , MURKI, Veerender , CHEEMALAPATI, Venkata Annapurna Sasikala
CPC分类号： C07D487/04 , A61K9/146 , C07B2200/07 , C07C209/44 , C07C209/48 , C07C253/30 , C07C255/46 , C07C2601/02 , C07C211/40
摘要： The present application relate to processes for preparing Ticagrelor and its intermediates that are useful in the processes. The application further provides salts of Ticagrelor, their processes and solid dispersion of Ticagrelor having Ticagrelor in amorphous form.
摘要翻译： 本申请涉及在该方法中有用的制备替卡格雷及其中间体的方法。 该应用进一步提供替卡格雷的盐，他们的过程和具有无定形形式的替卡格雷的蒂卡格瑞的固体分散体。
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公开(公告)号：WO2013144903A1
公开(公告)日：2013-10-03
申请号：PCT/IB2013/052500
申请日：2013-03-28
发明人： DAHANUKAR, Vilas Hareshwar , ANUMULA, Raghupathi reddy , HALDAR, Pranab , ELATI, Ravi Ram Chandrashekar , MYLAVARAPU, Ravi kumar , PALVAI, Prapulla kumar , PRATAPRAO, Anil Kumar
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present application relates to processes for preparing Dabigatran etexilate, including pharmaceutically acceptable salts or tautomers thereof.
摘要翻译： 本申请涉及制备达比加群酯的方法，包括其药学上可接受的盐或互变异构体。
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