公开(公告)号：WO2017214338A1

公开(公告)日：2017-12-14

申请号：PCT/US2017/036448

申请日：2017-06-07

申请人： DRAWBRIDGE HEALTH, INC.

发明人： JACKSON, Alicia ,  BEYERLEIN, Dagmar ,  CLARK, Sonya ,  RAVA, Richard, P.

IPC分类号： G01N1/28 ,  G01N1/10

CPC分类号： C12Q1/6806 ,  A61B5/150022 ,  A61B5/150389 ,  A61B5/150755 ,  A61B5/15105 ,  A61J1/05 ,  G01N1/405 ,  G01N33/6863 ,  G01N2333/525 ,  C12Q2531/113 ,  C12Q2535/122

摘要： Provided herein, are matrices and methods for the stabilization of proteins and nucleic acids. The stabilized proteins and nucleic acids described herein can be in a sample taken from a subject and can be subsequently stabilized and stored on the matrix. An analyte of interest can be concentrated and eluted for analysis from this sample. The stabilized proteins and nucleic acids described herein can be components of a sample preparation reagent, and the reagent is stored on the matrix and hydration of the matrix with a sample can result in a reaction occurring.

摘要翻译： 本文提供了用于稳定蛋白质和核酸的基质和方法。 本文所述的稳定的蛋白质和核酸可以在取自受试者的样品中，并且随后可以稳定并储存在基质上。 可以浓缩并洗脱感兴趣的分析物用于从该样品分析。 本文所述的稳定的蛋白质和核酸可以是样品制备试剂的组分，并且试剂被储存在基质上并且用样品水合基质可以导致反应发生。

公开(公告)号：WO2018132515A1

公开(公告)日：2018-07-19

申请号：PCT/US2018/013223

申请日：2018-01-10

申请人： DRAWBRIDGE HEALTH, INC.

发明人： BEYERLEIN, Dagmar ,  DREXEL, Masao ,  JORDAN, Brett L. ,  JACKSON, Alicia ,  JUNEAU, Kara

IPC分类号： A61B5/15

摘要： Disclosed herein are devices, apparatus, systems, methods and kits for collecting and storing a fluid sample from a subject. A device for collecting the fluid sample can include a housing comprising a recess having an opening, a vacuum chamber in the housing and in fluidic communication with the recess, and one or more piercing elements that are extendable through the opening to penetrate skin of the subject. The vacuum chamber can be configured for having a vacuum that draws the skin into the recess. The recess can be configured having a size or shape that enables an increased volume of the fluid sample to be accumulated in the skin drawn into the recess.