公开(公告)号：WO2023059948A1

公开(公告)日：2023-04-13

申请号：PCT/US2022/074223

申请日：2022-07-27

申请人： E-THERAPEUTICS PLC ,  JAYARAMAN, Muthusamy

发明人： MCCARTHY, Amy ,  CRAGGS, Graham ,  LONGDEN, James ,  DE SANTIAGO, Ines ,  BROWN, Duncan ,  ALI MORTAZAVI, Ahmad ,  MANNELLA, Viviana

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K47/61 ,  C07H21/00

摘要： The present invention relates to nucleic acid molecules for use in the treatment or prevention of disease.

公开(公告)号：WO2022162154A1

公开(公告)日：2022-08-04

申请号：PCT/EP2022/052069

申请日：2022-01-28

申请人： E-THERAPEUTICS PLC

发明人： MORTAZAVI, Ahmad Ali ,  MANNELLA, Viviana ,  JAYARAMAN, Muthusamy

IPC分类号： C07H15/04 ,  C07H15/08 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K47/54

摘要： The present invention provides novel conjugated oligonucleotide compounds, which are suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.

公开(公告)号：WO2022162157A1

公开(公告)日：2022-08-04

申请号：PCT/EP2022/052072

申请日：2022-01-28

申请人： E-THERAPEUTICS PLC

发明人： MORTAZAVI, Ahmad Ali ,  MANNELLA, Viviana ,  JAYARAMAN, Muthusamy

IPC分类号： C07H15/04 ,  C07H15/08 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K47/54 ,  C07D207/404

摘要： The present invention relates to novel conjugated oligonucleotide compounds, which are suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.

公开(公告)号：WO2022162153A1

公开(公告)日：2022-08-04

申请号：PCT/EP2022/052067

申请日：2022-01-28

申请人： E-THERAPEUTICS PLC

发明人： MORTAZAVI, Ahmad Ali ,  MANNELLA, Viviana ,  JAYARAMAN, Muthusamy

IPC分类号： C07H15/04 ,  C07H15/08 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K47/54 ,  C07D207/404

摘要： The present invention relates to novel conjugated oligonucleotide compounds, which are suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.

公开(公告)号：WO2022162161A1

公开(公告)日：2022-08-04

申请号：PCT/EP2022/052079

申请日：2022-01-28

申请人： E-THERAPEUTICS PLC

发明人： MANNELLA, Viviana ,  JAYARAMAN, Muthusamy ,  MORTAZAVI, Ahmad Ali

IPC分类号： C07H15/04 ,  C07H15/08 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K47/54

摘要： The present invention provides novel conjugated oligonucleotide compounds, which are suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.

公开(公告)号：WO2022162155A1

公开(公告)日：2022-08-04

申请号：PCT/EP2022/052070

申请日：2022-01-28

申请人： E-THERAPEUTICS PLC

发明人： MORTAZAVI, Ahmad Ali ,  MANNELLA, Viviana ,  JAYARAMAN, Muthusamy

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K47/61 ,  C07H21/00

摘要： The present invention relates to nucleic acid molecules for use in the treatment or prevention of disease.