公开(公告)号：WO2016067246A1

公开(公告)日：2016-05-06

申请号：PCT/IB2015/058361

申请日：2015-10-29

Applicant: ELTEK S.P.A.

Inventor： PIZZI, Marco ,  ZANIN, Massimo ,  MORTARA, Enrica ,  CHAPPOZ, Chadée ,  MAZZUCCO, Laura

IPC: A61M1/02 ,  A61B5/15

CPC classification number: A61B5/15003 ,  A61B5/150221 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150366 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15074 ,  A61B5/150755 ,  A61B5/153 ,  A61M1/029 ,  A61M39/223 ,  A61M39/24 ,  A61M2039/242 ,  A61M2202/0437

Abstract: A medical device for the separation of a concentrate enriched with cells from a biological fluid, in particular a concentrate of stromal or stem cells from medullar aspirate or venous blood, comprises: - a treatment container (3) for receiving and treating the biological fluid for the purposes of its separation into a number of fractions; - a first collection container (4), for receiving a first fraction of the fluid, in particular a fraction poor in said cells; - a second collection container (5), for receiving a second concentrated fraction of the fluid enriched with said cells; - a deviator valve (7) having a first way connected or prearranged for connection to the treatment container (3), a second way connected or prearranged for connection to the first collection container (4), and a third way connected or prearranged for connection to the second collection container (5); - a first line (10a) for connection of the treatment container (3) to the first way of the deviator valve (7), a second line (4a) for connection of the first collection container (4) to the second way of the deviator valve (7), and a third line for connection of the second collection container (5) with the third way of the deviator valve (7). The treatment container (3) is a syringe container with a plunger having a plunger stem (3c) associated in a releasable way to a corresponding plunger head, and the first connection line comprises a first transparent tube (10a), in particular a flexible transparent tube, and at least one of the second and third connection lines preferably comprises a second flexible tube (4a). At least one connection line, or each connection line, further comprises: at least one respective hydraulic connector (11, 13), for separable connection of a corresponding tube (10a, 4a) to the corresponding container (3, 4, 5) and/or to the corresponding way (7b, 7c, 7d) of the deviator valve (7); and at least one automatic-closing or one-way valve (12, 14a, 14b).

Abstract translation: 用于从富含细胞的生物液体，特别是髓质或干细胞的基质或干细胞的浓缩物分离浓缩物的医疗装置包括： - 用于接收和处理生物流体的处理容器（3） 将其分离成若干分数的目的; - 第一收集容器（4），用于接收所述流体的第一部分，特别是所述细胞中较差的部分; - 第二收集容器（5），用于接收富集所述细胞的流体的第二浓缩级分; - 偏转阀（7），其具有连接或预定列以连接到处理容器（3）的第一路径，连接或预先布置以用于连接到第一收集容器（4）的第二路，以及连接或预定义用于连接的第三路 到第二收集容器（5）; - 用于将处理容器（3）连接到偏离阀（7）的第一路的第一管线（10a），用于将第一收集容器（4）连接到第二回路 偏转阀（7）和用于将第二收集容器（5）与偏离阀（7）的第三路连接的第三管线。 处理容器（3）是具有柱塞的注射器容器，柱塞具有以可释放的方式与相应的柱塞头相关联的柱塞杆（3c），并且第一连接线包括第一透明管（10a），特别是柔性透明 并且第二和第三连接线中的至少一个优选地包括第二柔性管（4a）。 至少一个连接线或每个连接线还包括：至少一个相应的液压连接器（11,13），用于将相应的管（10a，4a）可分离地连接到相应的容器（3,4,5）和 /或偏转阀（7）的相应方式（7b，7c，7d）; 和至少一个自动关闭或单向阀（12,14a，14b）。