公开(公告)号：WO2015195453A4

公开(公告)日：2016-04-21

申请号：PCT/US2015035251

申请日：2015-06-11

Applicant: EMD MILLIPORE CORP

Inventor： NATARAJAN VENKATESH ,  LUTZ HERBERT ,  RAGHUNATH BALA

IPC: B01D61/14 ,  A61L2/00 ,  B01D15/12 ,  C07K1/16 ,  C07K1/34 ,  C07K1/36 ,  C07K16/06

CPC classification number: C07K1/18 ,  A61L2/0017 ,  B01D15/08 ,  B01D15/12 ,  B01D61/145 ,  B01D2311/08 ,  B01D2313/58 ,  B01D2315/10 ,  C07K1/22 ,  C07K1/34 ,  C07K1/36 ,  C07K16/00 ,  C07K16/065 ,  C07K2317/14 ,  B01D2311/2626

Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.

Abstract translation: 在各种实施方案中，本发明提供了用于从样品中的非靶蛋白中分离靶蛋白的方法，其包括增加样品中靶蛋白和非靶蛋白的浓度并随后将浓缩样品递送至色谱装置。 在其他实施方案中，本发明涉及通过将包含靶蛋白的浓缩样品递送至色谱装置来提高色谱装置对靶蛋白的容量的方法。

公开(公告)号：WO2015195453A3

公开(公告)日：2016-02-18

申请号：PCT/US2015035251

申请日：2015-06-11

Applicant: EMD MILLIPORE CORP

Inventor： NATARAJAN VENKATESH ,  LUTZ HERBERT ,  RAGHUNATH BALA

IPC: B01D61/14 ,  A61L2/00 ,  B01D15/12 ,  C07K1/16 ,  C07K1/34 ,  C07K1/36 ,  C07K16/06

CPC classification number: C07K1/18 ,  A61L2/0017 ,  B01D15/08 ,  B01D15/12 ,  B01D61/145 ,  B01D2311/08 ,  B01D2313/58 ,  B01D2315/10 ,  C07K1/22 ,  C07K1/34 ,  C07K1/36 ,  C07K16/00 ,  C07K16/065 ,  C07K2317/14 ,  B01D2311/2626

Abstract: In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device.

Abstract translation: 在各种实施方案中，本发明提供了从样品中分离靶蛋白与非靶蛋白的方法，包括增加样品中靶蛋白和非靶蛋白的浓度，并随后将浓缩样品递送至色谱装置。 在其它实施方案中，本发明涉及通过将含有靶蛋白的浓缩样品递送至色谱装置来增加靶蛋白色谱装置的容量的方法。