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    UNIT FOR TREATMENT OF A BIOPROCESS LIQUID WITH DISPOSABLE FLOW PATH ELEMENTS
    1.
    发明申请
    UNIT FOR TREATMENT OF A BIOPROCESS LIQUID WITH DISPOSABLE FLOW PATH ELEMENTS 审中-公开
    用于处理具有一次性流动路径元件的生物液体的单元

    公开(公告)号：WO2017097604A1

    公开(公告)日：2017-06-15

    申请号：PCT/EP2016/078760

    申请日：2016-11-25

    Applicant: GE HEALTHCARE BIO-SCIENCES AB

    Inventor： SINGH, Amit, Kumar ,  GEBAUER, Klaus ,  DATTA, Supti ,  LIDERFELT, Jakob ,  KARMARKAR, Nachiket ,  VERNEKAR, Ajit, S. ,  OLSSON, Mats ,  RAJAN, Thiyaga ,  SHARMA, Amit, K. ,  NUTALAPATI, Sasi, Kumar ,  LUNDSTROM, Fredrik ,  NEFF, Jean Pierre

    IPC: B01D61/18 ,  B01D15/00

    CPC classification number: B01D61/18 ,  B01D15/00 ,  B01D2313/18 ,  B01D2313/58

    Abstract: The invention discloses a first unit (1) for treatment of a bioprocess liquid comprising a first lateral face (2), a second lateral face (3) and a front face (4) which meets the two said lateral faces. The front face comprises: a plurality of valves (7) adapted to receive and act upon one or more legs (8) of a disposable flow path (6); optionally one or more pumps (10) adapted to receive and act upon one or more legs of the disposable flow path; optionally one or more sensors (11) adapted to receive and to measure one or more parameters in one or more legs of the disposable flow path; wherein the plurality of valves and optional pumps and sensors are vertically offset from each other to give one or more legs of a disposable flow path received by said valves and optional pumps and sensors a slope of at least 3.0 degrees from the horizontal plane (h).

    Abstract translation: 本发明公开了用于处理生物过程液体的第一单元（1），所述生物过程液体包括第一侧面（2），第二侧面（3）和与所述两个侧面（3）相遇的前表面（4） 所述侧面。 该正面包括：多个阀（7），其适于接收并作用于一次性流动路径（6）的一个或多个腿（8）; 任选地一个或多个泵（10），其适于接收并作用于所述一次性流动路径的一个或多个腿; 任选地一个或多个传感器（11），其适于接收并测量所述一次性流动路径的一个或多个腿中的一个或多个参数; 其中所述多个阀和可选的泵和传感器彼此垂直偏移以给出由所述阀和可选的泵和传感器接收的一次性流动路径的一个或多个腿，所述一次或多次腿与所述水平面（h）至少成3.0度的斜率，

    DISPOSABLE MEMBRANE STACKS
    2.
    发明申请
    DISPOSABLE MEMBRANE STACKS 审中-公开
    可拆卸膜片

    公开(公告)号：WO2015110829A1

    公开(公告)日：2015-07-30

    申请号：PCT/GB2015/050158

    申请日：2015-01-23

    Applicant: FUJIFILM MANUFACTURING EUROPE BV ,  FUJIFILM IMAGING COLORANTS LIMITED

    Inventor： VAN BAAK, Willem ,  BHIKHI, Vinodnarain ,  VAN BERCHUM, Bastiaan ,  VAN ENGELEN, Johannes

    IPC: B01D61/50 ,  B01D63/08

    CPC classification number: B01D61/50 ,  B01D63/082 ,  B01D65/003 ,  B01D2313/58 ,  B01D2315/16 ,  B01D2325/08 ,  B01D2325/40

    Abstract: A disposable, crossflow membrane stack suitable for use in an ion exchange unit, the stack comprising alternate dilution compartments and concentration compartments, each compartment being defined by a flat cation-permeable membrane (2) and a flat anion-permeable membrane (1) and at least two edges along which the cation- permeable and an anion-permeable membranes are permanently secured together wherein the cation-permeable membranes and/ or the anion-permeable membranes have a textured surface profile which keep said membranes apart and/or from touching each other and wherein the edges secured together define the direction in which liquid may flow through the compartments. Also claimed are ion exchange units comprising the stack, optionally comprising a quick- release securement means to allow facile attachment and release of modular units comprising the stacks.

    Abstract translation: 一种适合用于离子交换单元的一次性横流膜堆，所述堆叠包括可选的稀释室和浓缩隔室，每个室由平阳离子可渗透膜（2）和平阴离子可渗透膜（1）和 阳离子可渗透膜和阴离子可渗透膜永久固定在一起的至少两个边缘，其中阳离子可渗透膜和/或阴离子可渗透膜具有织构化的表面轮廓，其保持所述膜分离和/或接触每个 其中并且其中固定在一起的边缘限定液体可以流过隔室的方向。 还要求保护的是包括该堆叠的离子交换单元，任选地包括快速释放固定装置，以允许容易地附接和释放包括堆叠的模块化单元。

    SINGLE-USE MANIFOLD AND SENSORS FOR AUTOMATED, ASEPTIC TRANSFER OF SOLUTIONS IN BIOPROCESSING APPLICATIONS
    4.
    发明申请
    SINGLE-USE MANIFOLD AND SENSORS FOR AUTOMATED, ASEPTIC TRANSFER OF SOLUTIONS IN BIOPROCESSING APPLICATIONS 审中-公开
    用于自动化的单一使用说明和传感器，生物处理应用中解决方案的自由传递

    公开(公告)号：WO2007067882A2

    公开(公告)日：2007-06-14

    申请号：PCT/US2006061565

    申请日：2006-12-04

    Applicant: SENCAL LLC ,  SCHICK KARL G ,  UHEN DAVID

    Inventor： SCHICK KARL G ,  UHEN DAVID

    IPC: G01N27/10

    CPC classification number: B01D61/20 ,  B01D15/10 ,  B01D15/14 ,  B01D15/247 ,  B01D61/18 ,  B01D61/22 ,  B01D2311/06 ,  B01D2313/50 ,  B01D2313/58 ,  G01N27/10 ,  G01N2030/8813 ,  B01D2311/2649

    Abstract: Presteralized manifolds are provided which are designed for sterile packaging and single-use approaches. Disposable tubing and flexible-wall containers are assembled via aseptic connectors. These manifolds interact with valves and pumping equipment which can be operated by a controller which provides automated and accurate delivery of biotechnology fluid. The manifold also being used in conjunction with one or more conductivity sensors used to measure the conductivity of the biotechnology fluid. Such sensors interact with the controller or are connected to a separate user interface. The combination of disposable tubing, flexible-wall containers, aseptic connectors, manifold, controller, and conductivity sensors provides an aseptic environment while avoiding or reducing cleaning and quality assurance procedures.

    Abstract translation: 提供了预灭菌歧管，其设计用于无菌包装和一次性使用方法。 一次性管道和柔性壁容器通过无菌连接器组装。 这些歧管与阀和泵送设备相互作用，该设备可以由提供生物技术流体的自动和准确输送的控制器操作。 歧管还与用于测量生物技术流体的电导率的一个或多个电导率传感器结合使用。 这样的传感器与控制器交互或连接到单独的用户界面。 一次性管道，柔性壁容器，无菌连接器，歧管，控制器和电导率传感器的组合提供无菌环境，同时避免或减少清洁和质量保证程序。

    A BIOLOGICAL LIQUID TREATMENT INSTALLATION INCLUDING A BAG FOR A CIRCUIT
    7.
    发明申请
    A BIOLOGICAL LIQUID TREATMENT INSTALLATION INCLUDING A BAG FOR A CIRCUIT 审中-公开
    包括电路袋的生物液体处理安装

    公开(公告)号：WO2011161609A8

    公开(公告)日：2012-03-01

    申请号：PCT/IB2011052676

    申请日：2011-06-20

    Applicant: EMD MILLIPORE CORP ,  WEISSENBACH JEAN-LOUIS ,  CIROU SEBASTIEN

    Inventor： WEISSENBACH JEAN-LOUIS ,  CIROU SEBASTIEN

    IPC: B01D61/20 ,  F01L15/00 ,  F04B43/08

    CPC classification number: B01D63/00 ,  B01D61/20 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/13 ,  B01D2313/18 ,  B01D2313/58 ,  B01D2313/90 ,  B01D2315/10 ,  Y10T137/6851 ,  Y10T137/8593

    Abstract: The invention concerns a bag comprising a first conduit (13C) which extends longitudinally between a flow pump connector (1 1 C) emerging on a first side (68) and a tangential filter connector (1 1 M) emerging on a second side (69); a second conduit (13B) which extends longitudinally from a first side of said conduit (13C) between a supply container connector (1 1 B) emerging on said first side (68), and another tangential flow connector (1 1 N) emerging on said second side (69); a third conduit (13H) which extends from a second side of said conduit (13C), starting at a collecting container connector (1 1 J), until it enters said first conduit (13C); and a fourth conduit (13A) which extends from the first side of said conduit (13C), starting at a transfer pump connector (1 1A), until it enters said second conduit (13B).

    Abstract translation: 本发明涉及一种包括第一导管（13C）的袋子，该第一导管（13C）在出现在第一侧面（68）上的流动泵连接器（118）和在第二侧（69）上出现的切向过滤器连接器（110M）之间纵向延伸 ）; 第二导管（13B），其从所述导管（13C）的第一侧纵向延伸在出现在所述第一侧（68）上的供应容器连接器（11B）和另一切向流动连接器 所述第二面（69）; 从所述导管（13C）的第二侧延伸的第三导管（13H），从收集容器连接器（11J）开始，直至其进入所述第一导管（13C）; 以及从所述导管（13C）的第一侧从转移泵连接器（11A）开始直到其进入所述第二导管（13B）的第四导管（13A）。

    PLATELET RICH PLASMA CONCENTRATE APPARATUS AND METHOD
    9.
    发明申请
    PLATELET RICH PLASMA CONCENTRATE APPARATUS AND METHOD 审中-公开
    PLATELET RICH等离子体浓缩装置和方法

    公开(公告)号：WO2006086201A2

    公开(公告)日：2006-08-17

    申请号：PCT/US2006003599

    申请日：2006-01-30

    Applicant: HANUMAN LLC ,  CELL FACTOR TECHNOLOGIES INC ,  LEACH MICHAEL D

    Inventor： LEACH MICHAEL D ,  DORIAN RANDEL

    IPC: A61M1/36 ,  B04B5/00

    CPC classification number: B01D63/02 ,  A61M1/0281 ,  A61M1/3482 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  B01D2313/44 ,  B01D2313/58 ,  B01F11/0005 ,  B01F13/0052 ,  B04B5/0442 ,  B04B2005/0478

    Abstract: The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

    Abstract translation: 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板活化和破坏PRP中存在的任何痕量红细胞 。

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