公开(公告)号：WO2014045254A2

公开(公告)日：2014-03-27

申请号：PCT/IB2013/058772

申请日：2013-09-23

Applicant: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM

Inventor： HAAGMANS, Bartholomeus, Leonardus ,  BESTEBROER, Theodorus, Marinus ,  VAN BOHEEMEN, Sander ,  FOUCHIER, Ronaldus, Adrianus, Maria ,  OSTERHAUS, Albertus, Dominicus, Marcellinus, Erasmus ,  ZAKI, Ali, Moh ,  RAJ, Victor, Stalin ,  BOSCH, Berend, Jan

IPC: C12N7/00

CPC classification number: C12N7/00 ,  A61K35/76 ,  C07K14/005 ,  C07K14/70596 ,  C07K16/10 ,  C07K2319/30 ,  C12N9/485 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20032 ,  C12N2770/20034 ,  C12Q1/701 ,  C12Q2600/158 ,  C12Y304/14005 ,  G01N33/56983 ,  G01N33/573 ,  G01N2333/165 ,  G01N2333/948 ,  G01N2500/02

Abstract: The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus classifiable as belonging to the Order: Nidovirales; Family: Coronaviridae; Subfamily: Coronavirinae; Genus: Betacoronavirus; and non-Lineage A, non-Lineage B or non-Lineage D, human betacoronavirus. The invention also provides a human virus having a receptor binding domain (RBD) capable of binding to a dipeptidyl peptidase 4. The invention also provides diagnostic means and methods, prophylactic means and methods and therapeutic means and methods to be employed in the diagnosis, prevention and/or treatment of disease, in particular of respiratory disease, in particular of mammals, more in particular in humans.

Abstract translation: 本发明提供了分离的基本上哺乳动物的正义单链RNA病毒，其可归类为属于Nidovirales; 家庭：冠状病毒科 亚科：Coronavirinae; 属：Betacoronavirus; 和非谱系A，非谱系B或非谱系D，人类betacoronavirus。 本发明还提供了具有能够结合二肽基肽酶4的受体结合结构域（RBD）的人类病毒。本发明还提供了用于诊断，预防的诊断手段和方法，预防手段和方法以及治疗手段和方法 和/或治疗疾病，特别是呼吸系统疾病，特别是哺乳动物疾病，特别是在人类中。