公开(公告)号：WO2015057666A1

公开(公告)日：2015-04-23

申请号：PCT/US2014/060429

申请日：2014-10-14

Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

Inventor： BARIC, Ralph ,  AGNIHOTHRAM, Sudhakar ,  YOUNT, Boyd

IPC: G01N33/53 ,  G01N33/569 ,  C07K16/10 ,  C07K14/165

CPC classification number: G01N33/56983 ,  A61K39/215 ,  A61K2039/5252 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/575 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20071 ,  C12N2799/021 ,  G01N2333/165 ,  G01N2469/10 ,  G01N2469/20 ,  G01N2500/10 ,  G01N2500/20

Abstract: The present invention provides methods and compositions for detecting a coronavirus in a sample and identifying the subgroup of the coronavirus in the sample.

Abstract translation: 本发明提供用于检测样品中冠状病毒的方法和组合物，并鉴定样品中冠状病毒的亚组。

公开(公告)号：WO2014134439A1

公开(公告)日：2014-09-04

申请号：PCT/US2014/019402

申请日：2014-02-28

Applicant: NEW YORK BLOOD CENTER, INC. ,  ZHOU, Yusen ,  ZHAO, Guangyu

Inventor： ZHOU, Yusen ,  ZHAO, Guangyu ,  JIANG, Shibo ,  DU, Lanying

IPC: C07K14/165 ,  A61K39/215

CPC classification number: A61K39/215 ,  A61K39/12 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/005 ,  C07K16/10 ,  C07K2319/21 ,  C07K2319/30 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: Described herein are immunogenic compositions for preventing infection with Middle East respiratory syndrome coronavirus (MERS-CoV) wherein the immunogenic compositions comprise at least a portion of the MERS-CoV S protein and an immunopotentiator.

Abstract translation: 本文描述了用于预防中东呼吸综合征冠状病毒（MERS-CoV）感染的免疫原性组合物，其中免疫原性组合物包含至少一部分MERS-CoV S蛋白和免疫增强剂。

公开(公告)号：WO2014045254A2

公开(公告)日：2014-03-27

申请号：PCT/IB2013/058772

申请日：2013-09-23

Applicant: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM

Inventor： HAAGMANS, Bartholomeus, Leonardus ,  BESTEBROER, Theodorus, Marinus ,  VAN BOHEEMEN, Sander ,  FOUCHIER, Ronaldus, Adrianus, Maria ,  OSTERHAUS, Albertus, Dominicus, Marcellinus, Erasmus ,  ZAKI, Ali, Moh ,  RAJ, Victor, Stalin ,  BOSCH, Berend, Jan

IPC: C12N7/00

CPC classification number: C12N7/00 ,  A61K35/76 ,  C07K14/005 ,  C07K14/70596 ,  C07K16/10 ,  C07K2319/30 ,  C12N9/485 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20032 ,  C12N2770/20034 ,  C12Q1/701 ,  C12Q2600/158 ,  C12Y304/14005 ,  G01N33/56983 ,  G01N33/573 ,  G01N2333/165 ,  G01N2333/948 ,  G01N2500/02

Abstract: The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus classifiable as belonging to the Order: Nidovirales; Family: Coronaviridae; Subfamily: Coronavirinae; Genus: Betacoronavirus; and non-Lineage A, non-Lineage B or non-Lineage D, human betacoronavirus. The invention also provides a human virus having a receptor binding domain (RBD) capable of binding to a dipeptidyl peptidase 4. The invention also provides diagnostic means and methods, prophylactic means and methods and therapeutic means and methods to be employed in the diagnosis, prevention and/or treatment of disease, in particular of respiratory disease, in particular of mammals, more in particular in humans.

Abstract translation: 本发明提供了分离的基本上哺乳动物的正义单链RNA病毒，其可归类为属于Nidovirales; 家庭：冠状病毒科 亚科：Coronavirinae; 属：Betacoronavirus; 和非谱系A，非谱系B或非谱系D，人类betacoronavirus。 本发明还提供了具有能够结合二肽基肽酶4的受体结合结构域（RBD）的人类病毒。本发明还提供了用于诊断，预防的诊断手段和方法，预防手段和方法以及治疗手段和方法 和/或治疗疾病，特别是呼吸系统疾病，特别是哺乳动物疾病，特别是在人类中。

公开(公告)号：WO2005005596A2

公开(公告)日：2005-01-20

申请号：PCT/IB2004002237

申请日：2004-07-09

Applicant: CHINESE NAT HUMAN GENOME CT SH ,  GUANGDONG CT FOR DISEASE CONTR ,  GUANGZHOU CT FOR DISEASE CONTR ,  CHANGCHUN UNVERSITY OF AGRICUL ,  RUIJIN HOSPITAL AFFILIATED TO ,  SHANGHAI INST BIOL SCIENCES ,  NANFANG HOSPITAL FIRST MEDICAL ,  GUANGDONG J TECH SCIENCE DEV C ,  2ND AF HOSP SUN YAT SEN UNIV ,  ZHAO GUOPING ,  XU RUI HENG ,  WU XINYAN ,  TU CHENG ,  SONG HUAI-DONG ,  LI YIHONG ,  HOU JINLIN ,  XU JUN ,  MIN JUN

Inventor： ZHAO GUOPING ,  XU RUI HENG ,  WU XINYAN ,  TU CHENG ,  SONG HUAI-DONG ,  LI YIHONG ,  HOU JINLIN ,  XU JUN ,  MIN JUN

IPC: A61K39/12 ,  A61K39/215 ,  C07K14/165 ,  C12N20060101 ,  C12N7/00 ,  C12Q1/68 ,  C12Q1/70 ,  C12N

CPC classification number: C12N7/00 ,  A61K2039/5252 ,  A61K2039/5254 ,  C07K14/005 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12Q1/702

Abstract: Severe Acute Respiratory Syndrome ("SARS") is a human respiratory disease of recent origin, widespread infectivity, recurring incidence, and significant mortality. Although there is abundant evidence suggesting that the coronavirus responsible for the disease ("SARS-CoV") evolves during an outbreak, there is currently little data on the earliest strains of this coronavirus. The present invention is directed to the characterization of the genomic RNA sequences of these earliest SARS coronaviruses, to the identification of nucleotide positions within the SARS-CoV genomic RNA that are characteristic of the different evolutionary stages of the coronavirus, to kits based on these positions for use in diagnosis of the disease in patients, and for the development of vaccines to the disease based on the lowered virulence and contagiousness of these earliest strains of SARS-CoV.

Abstract translation: 严重急性呼吸系统综合症（“SARS”）是近来起源的人类呼吸道疾病，传染性广泛，发生率高，死亡率高。 尽管有大量证据表明，在疫情爆发期间，负责该疾病的冠状病毒（“SARS-CoV”）也会发生变化，但目前关于这种冠状病毒最早发病的数据很少。 本发明涉及这些最早的SARS冠状病毒的基因组RNA序列的鉴定，以鉴定冠状病毒不同进化阶段特征的SARS-CoV基因组RNA内的核苷酸位置，基于这些位置的试剂盒 用于诊断患者疾病，并根据这些最早的SARS-CoV毒株的毒力和感染性降低疫苗开发疫苗。

公开(公告)号：WO0109290A3

公开(公告)日：2001-08-23

申请号：PCT/MX0000031

申请日：2000-07-28

Applicant: LABARATORIO AVI MEX S A DE C V ,  LOZANO DUBERNARD BERNARDO ,  GAY GUTIERREZ MANUEL JOAQUIN ,  SARFATI MISRAHI DAVID ,  SOTO PRIANTE ERNESTO ,  SUAREZ MARTINEZ JESUS ALEJANDR ,  ARANDA MERLO MARIA EUGENIA ,  ESCAMILLA JUAREZ JORGE ALBERTO ,  HERNANDEZ RODRIGUEZ MARNA MARG ,  GARCIA GARCIA MX

Inventor： LOZANO DUBERNARD BERNARDO ,  GAY GUTIERREZ MANUEL JOAQUIN ,  SARFATI MISRAHI DAVID ,  SOTO PRIANTE ERNESTO ,  SUAREZ MARTINEZ JESUS ALEJANDR ,  ARANDA MERLO MARIA EUGENIA ,  ESCAMILLA JUAREZ JORGE ALBERTO ,  HERNANDEZ RODRIGUEZ MIRNA MARG ,  GARCIA GARCIA JUAN

IPC: A61K39/215 ,  C07K14/165 ,  C07K16/10 ,  C12N7/00 ,  C12N7/08 ,  C12N7/02 ,  C12N15/50

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K16/10 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20064

Abstract: Disclosed is an avian infectious bronchitis virus serotype which enables to control a type of avian infectious bronchitis which cannot be controlled through the use of known products or methods of the prior art. It is possible to obtain from the new serotype products such as vaccines, diagnostic kits, antibodies, antigens, hybridomas, proteins with specific amino acid sequences, inter alia, for the prevention, diagnosis and treatment of avian infectious bronchitis.

公开(公告)号：WO1995034686A1

公开(公告)日：1995-12-21

申请号：PCT/US1995007493

申请日：1995-06-12

Applicant: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

Inventor： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE ,  STORZ, Johannes

IPC: C12Q01/70

CPC classification number: C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12Q1/70 ,  G01N33/5091 ,  G01N33/56983 ,  Y10S435/948

Abstract: Coronaviruses can be a significant factor in bovine shipping fever. A new human rectal tumor cell line, HRT-18G, is suitable as a host cell line for the propagation of these bovine respiratory coronavirus-shipping fever viruses, and also is well suited for the propagation of other bovine coronaviruses.

Abstract translation: 冠状病毒可能是牛出血热的重要因素。 新的人直肠肿瘤细胞系HRT-18G适合作为这些牛呼吸道冠状病毒 - 寄生热病毒繁殖的宿主细胞系，也适用于其他牛冠状病毒的繁殖。

公开(公告)号：WO2018029383A1

公开(公告)日：2018-02-15

申请号：PCT/EP2017/070616

申请日：2017-08-14

Applicant: ANICON LABOR GMBH

Inventor： LIMAN, Martin ,  OLDOPP, Theresa ,  HANEKE, Jennifer ,  BIELENBERG, Wiebke ,  VOGEL, Natalie ,  RÖNCHEN, Swaantje ,  PETZOLDT, Diana ,  BEHR, Klaus-Peter

IPC: C12N7/00 ,  C07K14/005 ,  A61K39/12 ,  A61K35/76

CPC classification number: C12N7/00 ,  A61K35/76 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005 ,  C12N2770/20021 ,  C12N2770/20022

Abstract: Die Erfindung ist auf Mittel, Zusammensetzungen, Verwendungen und Verfahren zu einer neuen Variante des Infektiösen Bronchitis-Virus (IB-Virus) gerichtet.

Abstract translation: 本发明涉及传染性支气管炎（IB）病毒的新型变体的试剂，组合物，用途和方法。

公开(公告)号：WO2015121463A2

公开(公告)日：2015-08-20

申请号：PCT/EP2015/053188

申请日：2015-02-16

Applicant: INTERVET INTERNATIONAL B.V. ,  INTERVET INC.

Inventor： QIAO, Zhisong ,  COOK, Stephanie ,  O'CONNELL, Kevin ,  TARPEY, Ian

IPC: A61K39/12

CPC classification number: A61K39/215 ,  A61K9/0019 ,  A61K39/12 ,  A61K47/183 ,  A61K47/26 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20034

Abstract: The present invention is drawn to liquid stable poultry vaccines that comprise avian virus. The invention is also drawn to the manufacture of such vaccines methods of vaccinating animal subjects with these vaccines.

Abstract translation: 本发明涉及包含禽流感病毒的液体稳定的家禽疫苗。 本发明还涉及制造用这些疫苗给动物对象接种疫苗的方法。

公开(公告)号：WO2006020824A2

公开(公告)日：2006-02-23

申请号：PCT/US2005/028664

申请日：2005-08-11

Applicant: YALE UNIVERSITY ,  KAHN, Jeffrey, S. ,  ESPER, Frank

Inventor： KAHN, Jeffrey, S. ,  ESPER, Frank

CPC classification number: C12N7/00 ,  C12N2770/20021 ,  C12N2770/20051 ,  C12Q1/702

Abstract: In certain embodiments, the present invention relates to a novel coronavirus designed HCoV-NH. Also disclosed are isolated HCoV-NH nucleic acids, proteins encoded by the HCoV-NH nucleic acids, related expression vectors, related host cells, related antibodies, and related compositions. Methods of diagnosing infection with a coronavirus, methods of diagnosing Kawasaki disease, methods of identifying a therapeutic compound, and methods for treating coronavirus infection and for treating Kawasaki disease are also disclosed.

Abstract translation: 在某些实施方案中，本发明涉及一种新型冠状病毒设计的HCoV-NH。 还公开了分离的HCoV-NH核酸，由HCoV-NH核酸编码的蛋白质，相关表达载体，相关宿主细胞，相关抗体和相关组合物。 还公开了诊断冠状病毒感染的方法，川崎病诊断方法，鉴定治疗化合物的方法，以及治疗冠状病毒感染和治疗川崎病的方法。

公开(公告)号：WO2006007795A1

公开(公告)日：2006-01-26

申请号：PCT/CN2005/001088

申请日：2005-07-20

Applicant: THE UNIVERSITY OF HONG KONG

Inventor： YUEN, Kwokyung ,  WOO, Chiuyat, Patrick ,  LAU, Karpui, Susanna ,  CHAN, Kwokhung ,  POON, Litman ,  PEIRIS, Joseph, Sriyal, Malik ,  GUAN, Yi

IPC: C12N15/50

CPC classification number: C12Q1/701 ,  A61K39/12 ,  A61K39/215 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/20021 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The present invention provides the complete genomic sequence of a novel human coronavirus, coined as human coronavirus- HKU1 ("HCoV-HKU1"), isolated in Hong Kong. The virus belongs to the order Nidovirales of the family Coronaviridae, being a single-stranded RN virus of positive polarity. Futher study on nasopharyngeal aspirates from patients with community-acquired pnbeumonia has revealed that there are two genotypes, genotype A and genotype B, for this virus. In addition to the genomic sequences of these two genotypes, the invention provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the HCoV-HKU1are useful in preventing, diagnosing and/or treating the infection by HCoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the HCoV- HKU1 based on the nucleotide sequences and deduced amino acid sequences of the HCoV-HKU1.

Abstract translation: 本发明提供了在香港分离的作为人冠状病毒HKU1（“HCoV-HKU1”）的新型人冠状病毒的完整基因组序列。 病毒属于冠状病毒科的Nidovirales序列，是正极性的单链RN病毒。 对社区获得性pnbeumonia患者的鼻咽抽吸物的进一步研究表明，该病毒有两种基因型，A型和B型基因型。 除了这两种基因型的基因组序列外，本发明提供了CoV-HKU1完整基因组的推导的氨基酸序列。 HCoV-HKU1的核苷酸序列和推测的氨基酸序列可用于预防，诊断和/或治疗HCoV-HKU1的感染。 此外，本发明基于HCoV-HKU1的核苷酸序列和推导的氨基酸序列，提供使用重组和嵌合形式以及HCoV-HKU1的亚基的免疫原性和疫苗制剂。