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1.发明申请NUCLEOLIN-BINDING PEPTIDES, NUCLEOLIN-BINDING LYTIC PEPTIDES, FUSION CONSTRUCTS AND METHODS OF MAKING AND USING SAME 审中-公开核蛋白结合肽，核蛋白结合胶原蛋白，熔融结构及其制备和使用方法
公开(公告)号：WO2011031477A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/046623
申请日：2010-08-25
发明人： ALILA, Hector , LEUSCHNER, Carola
CPC分类号： C07K14/43563 , A61K38/00 , C07K14/4702 , C07K2319/30
摘要： The invention relates to nucleolin binding peptides, nucleolin binding peptides and anti-nucleolin antibody conjugates with cytotoxic activity, fusion constructs, methods of using nucleolin binding peptides and antibodies and fusion constructs thereof, and methods of treating various disorders, undesirable conditions and diseases treatble with nucleolin binding peptides and fusion constructs, such as undesirable or aberrant cell proliferation (hyperproliferation) or hyperproliferative disorders, including tumors, cancers, neoplasia and malignancies, angiogenesis related or dependent diseases, and inflammatory diseases and inflammation.
摘要翻译： 本发明涉及具有细胞毒活性的核仁林结合肽，核仁结合肽和抗核蛋白抗体缀合物，融合构建体，使用核仁核苷结合肽和抗体的方法及其融合构建体，以及治疗各种疾病，不良状况和疾病的方法， 核仁素结合肽和融合构建体，例如不期望的或异常的细胞增殖（过度增殖）或过度增殖性疾病，包括肿瘤，癌症，瘤形成和恶性肿瘤，血管发生相关或依赖性疾病，炎性疾病和炎症。
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2.发明申请LYTIC-PEPTIDE-HER2/NEU (HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2) LIGAND CONJUGATES AND METHODS OF USE 审中-公开LYTIC-PEPTIDE-HER2 / NEU（人类生殖因子受体2）配体结合体及使用方法
公开(公告)号：WO2011137245A2
公开(公告)日：2011-11-03
申请号：PCT/US2011/034338
申请日：2011-04-28
申请人： ESPERANCE PHARMACEUTICALS, INC. , ALILA, Hector , LEUSCHNER, Carola , JUBAN, Martha , COULTER, Ann
发明人： ALILA, Hector , LEUSCHNER, Carola , JUBAN, Martha , COULTER, Ann
IPC分类号： A61K39/395
CPC分类号： A61K38/10 , A61K38/16 , A61K45/00 , A61K47/64 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K7/08 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K2317/24 , C07K2317/526 , C07K2317/622
摘要： The invention relates to conjugates that bind to Her2/neu, methods of using conjugates that bind to Her2/neu and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express Her2/neu.
摘要翻译： 本发明涉及结合Her2 / neu的缀合物，使用结合Her2 / neu的缀合物的方法和治疗不希望的或异常的细胞增殖或过度增殖性疾病（例如表达Her2 / neu的肿瘤，癌症，瘤形成和恶性肿瘤）的方法。
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3.发明申请
公开(公告)号：WO2021195553A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/024467
申请日：2021-03-26
发明人： LEUSCHNER, Carola , ALILA, Hector , SOOD, Anil , KIM, Mark
IPC分类号： A61K38/00 , A61K38/10 , A61K38/16 , A61P35/00 , C07K7/08 , C07K14/00 , C07K14/72 , C07K16/28
摘要： The invention relates to fusion constructs and checkpoint inhibitors, methods of using fusion constructs and checkpoint inhibitors, and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.
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4.发明申请FOLLICLE-STIMULATING HORMONE (FSH)/LYTIC DOMAIN FUSION CONSTRUCTS AND METHODS OF MAKING AND USING SAME 审中-公开激光脉冲激光（FSH）/光域熔融结构及其制造和使用方法
公开(公告)号：WO2014078533A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/070093
申请日：2013-11-14
CPC分类号： C07K14/59 , A61K45/06 , C07K2319/00
摘要： The invention relates to fusion constructs, methods of using fusion constructs and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies.
摘要翻译： 本发明涉及融合构建体，使用融合构建体的方法和治疗不期望的或异常的细胞增殖或过度增殖性疾病如肿瘤，癌症，瘤形成和恶性肿瘤的方法。
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公开(公告)号：WO2014070957A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/067621
申请日：2013-10-30
发明人： LEUSCHNER, Carola , ALILA, Hector
IPC分类号： C07K16/44 , C07K14/00 , A61K47/42 , A61K39/395 , A61P35/00
CPC分类号： C07K7/08 , A61K38/00 , A61K47/6817 , A61K47/6849 , C07K16/2887 , C07K16/3015 , C07K16/3069 , C07K16/32 , C07K2317/524 , C07K2317/526 , C07K2317/622 , C07K2319/74
摘要： The invention relates to conjugates that bind to targets, methods of using conjugates that bind to targets and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express a target.
摘要翻译： 本发明涉及结合靶标的缀合物，使用与靶标结合的结合物的方法以及治疗不希望的或异常的细胞增殖或过度增殖性疾病（例如表达靶标的肿瘤，癌症，瘤形成和恶性肿瘤）的方法。
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