公开(公告)号：WO2020124059A1

公开(公告)日：2020-06-18

申请号：PCT/US2019/066413

申请日：2019-12-14

Applicant: ETERNITY BIOSCIENCE INC.

Inventor： LIU, Dong ,  LI, Puhui ,  ZHUANG, Linghang ,  ZHANG, Fengqi ,  CHEN, Lei ,  ZHANG, Xinzhu ,  SONG, Chunying ,  LIU, Suxing ,  MILLER, Matthew ,  HU, Qiyue ,  YAN, Yuna ,  LI, Jing ,  HE, Feng ,  TAO, Weikang

IPC: C07D403/14 ,  A61K31/4188 ,  C07D487/16 ,  C07D498/16

Abstract: Compounds of formula (I) useful as agonists of stimulator of interferon genes (STING), the preparation method therefor, pharmaceutcal compositions comprising the compounds, and the pharmaceutical uses for the treatment of STING-mediated diseases or disorders are disclosed.

公开(公告)号：WO2020006432A1

公开(公告)日：2020-01-02

申请号：PCT/US2019/039860

申请日：2019-06-28

Applicant: ETERNITY BIOSCIENCE INC.

Inventor： LIU, Dong ,  CHEN, Lei ,  ZHUANG, Linghang ,  LI, Puhui ,  ZHANG, Xinzhu ,  SONG, Chunying ,  MILLER, Matthew ,  HU, Qiyue ,  YAN, Yuna ,  HE, Feng ,  TAO, Weikang

IPC: A61K31/4164 ,  C07D403/14

Abstract: This application discloses a new class of fused tricyclic heterocycles of formula (I), preparation methods thereof, pharmaceutical compositions comprising these compounds, and pharmaceutically acceptable salts, solvates, or prodrugs thereof, and their uses for the treatment of diseases in which modulation of STING is beneficial, for example, cancers, pre-cancerous disorders, and viral infections.