公开(公告)号：WO2018208727A1

公开(公告)日：2018-11-15

申请号：PCT/US2018/031512

申请日：2018-05-08

Applicant: ETERNITY BIOSCIENCE INC.

Inventor： LIU, Jian ,  ZHUANG, Linghang ,  WU, Heping ,  LIU, Suxing ,  ZHANG, Rumin

IPC: C07H19/10 ,  C12N15/113

CPC classification number: C07H19/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07H19/23

Abstract: Nucleoside and nucleotide compounds and analogues, and pharmaceutically acceptable compositions thereof, as inhibitors of CD73 for the treatment of diseases or disorders associated with CD73 activities, especially cancers, and methods of preparing these compounds are disclosed.

公开(公告)号：WO2021158626A1

公开(公告)日：2021-08-12

申请号：PCT/US2021/016364

申请日：2021-02-03

Applicant: ETERNITY BIOSCIENCE INC.

Inventor： LIU, Dong ,  ZHAO, Peng ,  LIU, Jian ,  ZHUANG, Linghang ,  ZHANG, Fengqi ,  ZHANG, Xinzhu ,  SONG, Chunying ,  LIU, Suxing ,  LI, Jing

IPC: A61K31/4166 ,  A61K31/417 ,  A61P19/04 ,  C07D233/76 ,  C07D233/78 ,  C07D401/12

Abstract: Compounds of formula (I) useful as inhibitors of ADAMTS-5 and/or ADAMTS-4, pharmaceutical compositions thereof, and use of them as therapeutic agents for the treatment of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis, are disclosed.

公开(公告)号：WO2020205538A1

公开(公告)日：2020-10-08

申请号：PCT/US2020/025269

申请日：2020-03-27

Applicant: ETERNITY BIOSCIENCE INC.

Inventor： LIU, Jian ,  WU, Heping ,  ZHUANG, Linghang ,  LIU, Suxing ,  ZHANG, Rumin ,  LI, Jing ,  HE, Feng ,  TAO, Weikang

IPC: A61K31/7076 ,  A61K9/00 ,  A61K39/395

Abstract: This application discloses CD73 inhibitors of the general formula (I) and analogs thereof, pharmaceutical compositions containing these compounds, methods of preparing them, and use of these compounds as therapeutic agents for the treatment of diseases or conditions associated with CD73 activity, such as various cancers. Formula (I).

公开(公告)号：WO2021202652A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/025073

申请日：2021-03-31

Applicant: ETERNITY BIOSCIENCE INC.

Inventor： LIU, Jian ,  YAN, Yinfa ,  LI, Puhui ,  ZHUANG, Linghang ,  ZHOU, Yu ,  LIU, Suxing

IPC: A61K31/495 ,  A61K31/50 ,  A61K31/501 ,  C07D237/06 ,  C07D237/20 ,  C07D403/12

Abstract: This application discloses Tyk-2 inhibitors represented by the general formula (I) and analogs thereof, pharmaceutical compositions containing these compounds, method of preparing them, and use of these compounds as therapeutic agents for the treatment of diseases or conditions associated with Tyk-2 activity, such as autoimmune diseases and cancers.

公开(公告)号：WO2020047082A1

公开(公告)日：2020-03-05

申请号：PCT/US2019/048552

申请日：2019-08-28

Applicant: ETERNITY BIOSCIENCE INC.

Inventor： LIU, Jian ,  WU, Heping ,  ZHUANG, Linghang ,  LIU, Suxing ,  ZHANG, Rumin ,  HE, Feng ,  TAO, Weikang

IPC: A61K31/517 ,  C07D473/34 ,  C07H19/16

Abstract: This application discloses CD73 inhibitors represented by the general formula (I) and analogs thereof, pharmaceutical compositions containing these compounds, methods of preparing them, and use of these compounds as therapeutic agents for the treatment of diseases or conditions associated with CD73 activity, such as various cancers.

公开(公告)号：WO2020124059A1

公开(公告)日：2020-06-18

申请号：PCT/US2019/066413

申请日：2019-12-14

Applicant: ETERNITY BIOSCIENCE INC.

Inventor： LIU, Dong ,  LI, Puhui ,  ZHUANG, Linghang ,  ZHANG, Fengqi ,  CHEN, Lei ,  ZHANG, Xinzhu ,  SONG, Chunying ,  LIU, Suxing ,  MILLER, Matthew ,  HU, Qiyue ,  YAN, Yuna ,  LI, Jing ,  HE, Feng ,  TAO, Weikang

IPC: C07D403/14 ,  A61K31/4188 ,  C07D487/16 ,  C07D498/16

Abstract: Compounds of formula (I) useful as agonists of stimulator of interferon genes (STING), the preparation method therefor, pharmaceutcal compositions comprising the compounds, and the pharmaceutical uses for the treatment of STING-mediated diseases or disorders are disclosed.

公开(公告)号：WO2020006432A1

公开(公告)日：2020-01-02

申请号：PCT/US2019/039860

申请日：2019-06-28

Applicant: ETERNITY BIOSCIENCE INC.

Inventor： LIU, Dong ,  CHEN, Lei ,  ZHUANG, Linghang ,  LI, Puhui ,  ZHANG, Xinzhu ,  SONG, Chunying ,  MILLER, Matthew ,  HU, Qiyue ,  YAN, Yuna ,  HE, Feng ,  TAO, Weikang

IPC: A61K31/4164 ,  C07D403/14

Abstract: This application discloses a new class of fused tricyclic heterocycles of formula (I), preparation methods thereof, pharmaceutical compositions comprising these compounds, and pharmaceutically acceptable salts, solvates, or prodrugs thereof, and their uses for the treatment of diseases in which modulation of STING is beneficial, for example, cancers, pre-cancerous disorders, and viral infections.