公开(公告)号：WO2021105481A1

公开(公告)日：2021-06-03

申请号：PCT/EP2020/083803

申请日：2020-11-27

Applicant: FACIO INTELLECTUAL PROPERTY B.V.

Inventor： LOKE, Pui Leng ,  DE MAEYER, Joris Herman ,  PACE, Robert David Matthew ,  ELLWOOD, Simon Fletcher ,  FOULKES, Gregory ,  ANIGHORO, Andrew ,  RUEDA-ZUBIAURRE, Ainoa ,  RICHARDS, Jonathan Philip ,  DAVENPORT, Adam James ,  LECCI, Cristina ,  DICKIE, Anthony Paul ,  SCHNORRENBERG, Gerd

IPC: A61K31/428 ,  A61K31/429 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61P35/00 ,  A61P21/00 ,  C07D401/04 ,  C07D403/04 ,  C07D519/00

Abstract: The present invention relates to compounds that act as DUX4 repressors, suitable for the treatment of diseases related to DUX4 expression, such as muscular dystrophies. It also relates to use of such compounds, or to methods of use of such compounds.

公开(公告)号：WO2021105474A1

公开(公告)日：2021-06-03

申请号：PCT/EP2020/083796

申请日：2020-11-27

Applicant: FACIO INTELLECTUAL PROPERTY B.V.

Inventor： LOKE, Pui Leng ,  DE MAEYER, Joris Herman ,  PACE, Robert David Matthew ,  FOULKES, Gregory ,  RUEDA-ZUBIAURRE, Ainoa ,  ELLWOOD, Simon Fletcher ,  DAVENPORT, Adam James ,  DICKIE, Anthony Paul ,  SCHNORRENBERG, Gerd

IPC: A61K31/4174 ,  A61K31/4178 ,  A61K31/4439 ,  A61P21/00 ,  A61P35/00 ,  C07D211/00 ,  C07D233/00 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/08 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107

Abstract: The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies. It also relates to use of such compounds, or to methods of use of such compounds.