公开(公告)号：WO1996000102A1

公开(公告)日：1996-01-04

申请号：PCT/US1995008067

申请日：1995-06-26

Applicant: FOCAL, INC.

Inventor： FOCAL, INC. ,  ROTH, Laurence, A. ,  HERMAN, Stephen, J. ,  KHOSRAVI, Farhad ,  MELANSON, David ,  DUMONT, Michael ,  CAMPBELL, Patrick, K. ,  SPIRIDIGLIOZZI, John, C.

IPC: A61M25/10

CPC classification number: A61F2/82 ,  A61B17/00491 ,  A61F2250/0067 ,  A61M25/1011 ,  A61M35/00 ,  A61M2025/0076 ,  A61M2025/1052

Abstract: Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices may include a molding member for providing a thick polymeric gel. Alternatively, devices without a molding member may be used to carry out an interfacial polymerization procedure.

Abstract translation: 公开了用于在体腔和空间的内表面上提供聚合物层的装置。 该装置可以包括近端和远端阻塞元件以限定治疗空间，以及光发射器以提供用于光聚合程序的光。 所述装置可以包括用于提供厚聚合物凝胶的模制构件。 或者，可以使用没有模制构件的装置来进行界面聚合程序。

公开(公告)号：WO1996011671A1

公开(公告)日：1996-04-25

申请号：PCT/US1995014103

申请日：1995-10-11

Applicant: FOCAL, INC.

Inventor： FOCAL, INC. ,  ROTH, Laurence, A. ,  HERMAN, Stephen, Jack

IPC: A61K09/127

CPC classification number: A61K9/0024 ,  A61K9/127 ,  Y10S514/824 ,  Y10S514/964 ,  Y10S514/965

Abstract: Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as liposomes which facilitates transfer of the bioactive molecules into the targeted tissue. Targeting of the bioactive molecules can also be achieved by selection of an encapsulating medium of an appropriate size whereby the medium serves to deliver the molecules to a particular target. For example, encapsulation of nucleic acid molecules or biologically active proteins within biodegradable, biocompatible polymeric microparticles which are appropriately sized to infiltrate, but remain trapped within, the capillary beds and alveoli of the lungs can be used for targeted delivery to these regions of the body following administration to a patient by infusion or injection.

Abstract translation: 通过将生物活性分子固定在与需要递送的细胞相邻的聚合物材料中，生物活性分子（例如编码蛋白质的核酸分子）的递送可以显着增强，其中生物活性分子被包封在诸如脂质体的载体中，这有助于转移 的生物活性分子进入靶组织。 生物活性分子的靶向也可以通过选择合适尺寸的包封介质来实现，由此介质用于将分子递送到特定靶。 例如，将核酸分子或生物活性蛋白质包封在可生物降解的生物相容性聚合物微粒中，其适当尺寸以渗透，但仍被捕获在肺的毛细血管床和肺泡内，可以用于目标递送到身体的这些区域 通过输注或注射给予患者。