公开(公告)号：WO1996038049A1

公开(公告)日：1996-12-05

申请号：PCT/US1996008005

申请日：1996-05-30

Applicant: FUISZ TECHNOLOGIES, LTD.

Inventor： FUISZ TECHNOLOGIES, LTD. ,  CHERUKURI, Subraman, R. ,  YANG, Robert, K. ,  BOWLES, Cecil, A. ,  ZAMUDIO-TENA, Jose, F. ,  BHOWMIK, Santi, R.

IPC: A23G03/00

CPC classification number: A23G3/36 ,  A23G3/10 ,  A23G3/2015 ,  A23G3/362 ,  A23G3/44 ,  A23G3/48 ,  A23G3/52

Abstract: The present invention is a new method of making a confectionery mass, such as a nougat, by hydrating sufficiently to form the mass without the need for cooking to drive off moisture. The present invention also includes a product prepared by positively hydrating a mixture of confectionery ingredients including a hydrobinding component and shearform product.

Abstract translation: 本发明是通过充分水合而形成质量而不需要烹调以除去水分的方式制造糖果块的新方法。 本发明还包括通过将包含加氢结合组分和剪切形式产物的糖食成分的混合物积极水合制备的产品。

公开(公告)号：WO1993024154A1

公开(公告)日：1993-12-09

申请号：PCT/US1993005307

申请日：1993-06-02

Applicant: FUISZ TECHNOLOGIES, LTD. ,  FUISZ, Richard, C.

Inventor： FUISZ TECHNOLOGIES, LTD.

IPC: A61L15/62

CPC classification number: A61K9/70 ,  A61L17/005 ,  A61L2300/406 ,  A61L2300/43 ,  A61L2300/604 ,  Y10S424/13 ,  Y10S424/15

Abstract: Biodegradable controlled release delivery systems using melt-spun biodegradable polymers as carriers for bio-effecting agents such as pharmaceutical actives are disclosed. Oral dosage forms as well as implants are described.

Abstract translation: 公开了使用熔融生物降解聚合物作为生物效应剂如药物活性剂的载体的可生物降解的控制释放递送系统。 描述口服剂型以及种植体。

公开(公告)号：WO1997008950A1

公开(公告)日：1997-03-13

申请号：PCT/US1996014457

申请日：1996-09-09

Applicant: FUISZ TECHNOLOGIES, LTD.

Inventor： FUISZ TECHNOLOGIES, LTD. ,  FRISBEE, Steven ,  MYERS, Garry, L. ,  FUISZ, Richard, C. ,  BLAKE, Andrea ,  YANG, Robert, K.

IPC: A01N25/28

CPC classification number: A61K9/146 ,  A01N25/10 ,  A61K9/70 ,  B01J13/04

Abstract: The present invention is a method of preparing a system for delivering a bio-affecting agent and the composition prepared thereby. The invention includes forming a solid dispersion of the bio-affecting agent in an increased energy state in a water-soluble polymer which is compatible with the bio-affecting agent. As a consequence of transforming the bio-affecting agent to an increased-energy condition and freezing it in such condition in a water-soluble polymer, the bio-affecting agent is made available ("bio-available") to a bio-system upon dissolution of the polymer. This method and composition has been found extremely effective for delivery of otherwise substantially non-soluble drugs and other bio-affecting ingredients.

Abstract translation: 本发明是制备用于递送生物影响剂的系统的方法和由其制备的组合物。 本发明包括在与生物影响剂相容的水溶性聚合物中以增加的能量状态形成生物影响剂的固体分散体。 作为将生物影响剂转化为增加能量条件并在这种条件下在水溶性聚合物中冷冻的结果，生物影响剂在生物系统上可用（“生物可用”） 聚合物的溶解。 已经发现，该方法和组合物对于递送基本上不可溶的药物和其它生物影响成分非常有效。

公开(公告)号：WO1996035566A1

公开(公告)日：1996-11-14

申请号：PCT/US1996006506

申请日：1996-05-08

Applicant: FUISZ TECHNOLOGIES, LTD.

Inventor： FUISZ TECHNOLOGIES, LTD. ,  BOGUE, Beuford, A. ,  MYERS, Garry, L.

IPC: B29C43/02

CPC classification number: B30B15/302 ,  A23G3/10 ,  A23G3/346 ,  A23G3/368 ,  A23G2200/06 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2095 ,  A61K9/70 ,  B30B11/027 ,  B30B11/10 ,  B30B11/14 ,  C13B30/021 ,  C13B50/00

Abstract: The present invention provides a method and apparatus (10) for forming a compression dosage unit such as a tablet. The method of the present invention includes dispensing a premeasured volume of tableting feedstock (30) into a product tray (25). The feedstock is compacted into a tablet within the product tray. The product tray may be further packaged for distribution and sale. The apparatus of the present invention includes a dossiter (39) for dispensing the premeasured volume of feedstock into the product tray from a reservoir (40). A die is insertable into the product tray to form the tablet therein. The dossiter may be used to form the tablets within the product tray.

Abstract translation: 本发明提供了一种用于形成诸如片剂的压缩剂量单位的方法和装置（10）。 本发明的方法包括将预先测量的压片原料（30）分配到产品托盘（25）中。 原料在产品托盘内压实成片剂。 产品托盘可以进一步包装以进行分销和销售。 本发明的装置包括用于从储存器（40）将预先测量的原料体积分配到产品托盘中的一个分配器（39）。 模具可插入产品托盘中以在其中形成片剂。 数位机可用于在产品托盘内形成片剂。

公开(公告)号：WO1996035565A1

公开(公告)日：1996-11-14

申请号：PCT/US1996006448

申请日：1996-05-08

Applicant: FUISZ TECHNOLOGIES, LTD.

Inventor： FUISZ TECHNOLOGIES, LTD. ,  BOGUE, Beuford, A. ,  MEYERS, Garry, L.

IPC: B29C43/02

CPC classification number: A23G3/10 ,  A23G3/346 ,  A23G3/368 ,  A23G2200/06 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2095 ,  A61K9/70 ,  B30B11/027 ,  B30B11/10 ,  B30B11/14 ,  C13B30/021 ,  C13B50/00

Abstract: A method and apparatus (10) is provided for the formation of a tablet (21) from tableting feedstock (20). An elongate die is provided which has a cavity (16) defined by an inner wall (18). A pair of die punches (22, 24) are insertably positioned within the cavity. The die punches include opposed facing surfaces (30) for supporting therebetween tableting feedstock. The die punch are relatively movable within the cavity to a tablet forming position to compress the feedstock into a tablet. The tablet forming positions defined by the facing die punch surfaces are spaced apart a sufficient distance so as to maintain the formed tablet in contact with the inner wall of the cavity so as to retain the tablet within the cavity upon removal of the die punches.

Abstract translation: 提供了一种用于从压片原料（20）形成片剂（21）的方法和装置（10）。 提供了一个细长模具，其具有由内壁（18）限定的空腔（16）。 一对模冲头（22,24）可插入地定位在腔内。 冲模包括相对的相对的表面（30），用于在其间进行压片原料的支撑。 模具冲头在空腔内相对移动到片剂形成位置以将原料压缩成片剂。 由相对的模具冲头表面限定的片剂形成位置被间隔开足够的距离，以便保持形成的片剂与空腔的内壁接触，以便在去除模具冲头时将片剂保持在空腔内。

公开(公告)号：WO1996035564A1

公开(公告)日：1996-11-14

申请号：PCT/US1996006446

申请日：1996-05-08

Applicant: FUISZ TECHNOLOGIES, LTD.

Inventor： FUISZ TECHNOLOGIES, LTD. ,  BOGUE, Beuford, A. ,  MYERS, Garry, L.

IPC: B29C43/02

CPC classification number: B30B15/302 ,  A23G3/10 ,  A23G3/346 ,  A23G3/368 ,  A23G2200/06 ,  A61J3/10 ,  A61K9/0056 ,  A61K9/2018 ,  A61K9/2095 ,  A61K9/70 ,  B30B11/027 ,  B30B11/10 ,  B30B11/14 ,  C13B30/021 ,  C13B50/00

Abstract: A method and apparatus provides for the formation of compression dosage units from tableting feedstock (36). A feedstock dossiter (10) is provided including an open ended chamber (26) for insertion into a reservoir containing the tableting feedstock. The dossiter includes a movable die punch (30) which is movable within the chamber between at least two positions. A first position away from the open end (24) of the chamber provides for the collection of a preselected volume of tableting feedstock from the reservoir. The die punch is movable to a second position which effects formation of the tablet within the accumulation chamber. The dossiter may be used with a fixed die punch to form the tablet.

Abstract translation: 方法和装置提供从压片原料（36）形成压缩剂量单位。 提供原料密封件（10），其包括用于插入到包含压片原料的储存器中的开放式端室（26）。 软管包括一个活动模具冲头（30），它可在室内至少在两个位置之间移动。 离开室的开口端（24）的第一位置提供从储存器收集预选量的压片原料。 模具冲头可移动到第二位置，其实现在积聚室内形成片剂。 压花机可以与固定模具冲头一起使用以形成片剂。