公开(公告)号：WO2021122942A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/086700

申请日：2020-12-17

Applicant: FUNDACIÓN CIDETEC

Inventor： NAVASCUEZ LOMINCHAR, Marcos ,  LOINAZ BORDONABE, Iraida ,  DUPIN, Damien ,  LLOP ROIG, Jordi ,  LÓPEZ-GALLEGO, Fernando

IPC: C08B37/02 ,  C08B37/08 ,  C08L5/02 ,  C08L5/08 ,  A61K47/36 ,  A61K9/51 ,  A61K9/107 ,  A61K9/5138 ,  A61K9/5161 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0072

Abstract: The present invention relates to the use of a methacrylate or acrylate modified polysaccharide; or a single-chain polysaccharide methacrylate or acrylate-based nanoparticle, having a surface tension measured by Du Noüy Ring method equal to or lower than 63 mN/m, as oil-in-water emulsion stabilizer; and an oil-in-water emulsion stabilizer composition, and an oil-in-water emulsion containing them. It also relates to processes for their preparation, and their uses.

公开(公告)号：WO2020212545A1

公开(公告)日：2020-10-22

申请号：PCT/EP2020/060804

申请日：2020-04-17

Applicant: FUNDACIÓN CIDETEC

Inventor： GRACIA ESPAÑA, Raquel ,  MOVELLAN, Julie ,  MARRADI, Marco ,  DUPIN, Damien ,  LOINAZ BORDONABE, Iraida ,  MURGIA ESTEVE, Xabier

IPC: A61K47/69 ,  A61K47/61 ,  A61P31/04

Abstract: The present invention relates to a water-dispersible single-chain dextran methacrylate or acrylate based nanoconjugate, which comprises a water-dispersible single-chain dextran methacrylate or acrylate based nanoparticle and one or more hydrophilic active ingredients, and having: a particle size from 3 nm to 50 nm, a zeta potential from -25 mV to +20 mV, a percentage of intra-molecular crosslinking from 3% to 45% molar % of the total amount of monomer units present in the dextran methacrylate or acrylate chain, and a drug loading from 20% to 40% by weight of the drug in relation to the total weight of the nanoconjugate. It also relates to processes for their preparation, compositions containing them and their use in therapy.

公开(公告)号：WO2019068936A1

公开(公告)日：2019-04-11

申请号：PCT/EP2018/077365

申请日：2018-10-08

Applicant: UNIVERSITÉ DE BORDEAUX ,  INSTITUT POLYTECHNIQUE DE BORDEAUX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  FUNDACIÓN CIDETEC

Inventor： LECOMMANDOUX, Sébastien ,  DUPIN, Damien ,  LOINAZ BORDONABE, Iraida ,  GRANDE TELLERIA, Hans-Jürgen

IPC: B01J13/06 ,  A61K9/127 ,  B01J13/08 ,  A61K47/34

CPC classification number: B01J13/08 ,  A61K9/1075 ,  A61K9/5146 ,  A61K47/34

Abstract: The present invention relates to the use of a copolymer having the following formula (II), wherein: - A 1 is a linker, preferably an enzyme-cleavable peptide sequence, and y is 0 or 1; - AA is a residue of a hydrophobic amino acid; - x is an integer comprised between 17 and 270; - n is an integer comprised between 5 and 170; and - m is an integer comprised between 0 and 80; optionally in the presence of a co-surfactant, as surfactant for the stabilization of an emulsion at a pH between 4 and 6.5.