公开(公告)号：WO2020212545A1

公开(公告)日：2020-10-22

申请号：PCT/EP2020/060804

申请日：2020-04-17

Applicant: FUNDACIÓN CIDETEC

Inventor： GRACIA ESPAÑA, Raquel ,  MOVELLAN, Julie ,  MARRADI, Marco ,  DUPIN, Damien ,  LOINAZ BORDONABE, Iraida ,  MURGIA ESTEVE, Xabier

IPC: A61K47/69 ,  A61K47/61 ,  A61P31/04

Abstract: The present invention relates to a water-dispersible single-chain dextran methacrylate or acrylate based nanoconjugate, which comprises a water-dispersible single-chain dextran methacrylate or acrylate based nanoparticle and one or more hydrophilic active ingredients, and having: a particle size from 3 nm to 50 nm, a zeta potential from -25 mV to +20 mV, a percentage of intra-molecular crosslinking from 3% to 45% molar % of the total amount of monomer units present in the dextran methacrylate or acrylate chain, and a drug loading from 20% to 40% by weight of the drug in relation to the total weight of the nanoconjugate. It also relates to processes for their preparation, compositions containing them and their use in therapy.

公开(公告)号：WO2016071258A1

公开(公告)日：2016-05-12

申请号：PCT/EP2015/075404

申请日：2015-11-02

Applicant: FUNDACIÓN CIDETEC

Inventor： AIERTZA OTXOTORENA, Miren Karmele ,  SÁNCHEZ ABELLA, Laura ,  BENITO COLLADO, Ana Belén ,  LOINAZ BORDONABE, Iraida ,  CABAÑERO, Germán ,  GRANDE, Hans-Jürgen ,  MARRADI, Marco ,  GRACIA ESPAÑA, Raquel

IPC: C08F220/34 ,  A61K9/51

CPC classification number: C08F8/32 ,  A61K47/6933 ,  A61K47/6939 ,  A61K49/0093 ,  A61K49/1818 ,  C08F220/34 ,  C08G75/12

Abstract: The present invention comprises a process for preparing water-dispersible single-chain polymeric nanoparticles, which comprises cross-linking a polymer having a solubility equal to or higher than 100 mg per litre of water, and an amount of complementary reactive groups comprised from 5 to 60 molar % of the total amount of monomer units present in the polymer chain; with a crosslinking agent having crosslinkable groups; at a temperature comprised from 20 to 25°C in the absence of a catalyst; to obtain water-dispersible conjugates and compositions containing the nanoparticle; and the use thereof.

Abstract translation: 本发明包括一种制备水分散性单链聚合物纳米颗粒的方法，该方法包括使溶解度等于或高于100mg /升水的聚合物交联，并且包含5〜 存在于聚合物链中的单体单元总量的60摩尔％ 具有可交联基团的交联剂; 在不存在催化剂的情况下在20至25℃的温度下进行; 以获得含有纳米颗粒的水分散性缀合物和组合物; 及其用途。