公开(公告)号：WO2020074733A1

公开(公告)日：2020-04-16

申请号：PCT/EP2019/077662

申请日：2019-10-11

Applicant: GAMBRO LUNDIA AB

Inventor： POUCHOULIN, Dominique ,  KARLSSON, David

IPC: A61M1/36

Abstract: An extracorporeal blood treatment apparatus, comprises: at least a pressure sensor (24, 25) located in a respective measurement site on an extracorporeal blood circuit (6, 7); an electronic control unit (23) operatively connected at least to the pressure sensor (24, 25). The electronic control unit (23) is configured to perform at least the following procedure: receiving from the pressure sensor (24, 25) a signal correlated to a measured blood pressure (Plmeasured, P2measured) in the measurement site; correcting the blood measured pressure (Plmeasured, P2measured) through a mathematical correction model to obtain a blood actual pressure (Pinlet, Poutlet) in a reference site other than the measurement site. Between the reference site and the measurement site, a circuit section and, optionally, at least one additional device (18, 27, 28) is/are positioned. The mathematical correction model is a model of a pressure drop in the circuit section and, optionally, in the additional device (18, 27, 28).

公开(公告)号：WO2019129719A1

公开(公告)日：2019-07-04

申请号：PCT/EP2018/086631

申请日：2018-12-21

Applicant: GAMBRO LUNDIA AB

Inventor： COURT, Thierry ,  POUCHOULIN, Dominique

IPC: A61M1/34 ,  A61M1/36

CPC classification number: A61M1/3646 ,  A61M1/3431 ,  A61M1/3649

Abstract: An apparatus (1) for CRRT is provided comprising a blood circuit (10, 20, 30, 60) with a blood removal line (20), a treatment unit (10), and a blood return line (30). A replacement fluid container (78) is configured for containing a medical fluid, a pre-infusion line (70) has a first end (70-1) connected to the replacement fluid container (78) and a second end (70-2) connected to the blood removal line (20) and a blood pump (22) is active on the blood circuit. A replacement fluid pump (72) is active on the pre-infusion line (70), a dialysate circuit (40, 50, 70) comprises an effluent line (50) configured for discharging fluid from the second chamber, and a control unit (80) is connected to the replacement fluid pump (72) and to the blood pump (22) and is configured for performing a rinse-back procedure for restituting blood to a patient. The rinse-back procedure comprises conveying blood contained in the blood circuit (10, 20, 30, 60) towards the second end (30-2) of the blood return line (30) using the medical fluid.

公开(公告)号：WO2018019926A1

公开(公告)日：2018-02-01

申请号：PCT/EP2017/068983

申请日：2017-07-27

Applicant: GAMBRO LUNDIA AB

Inventor： POUCHOULIN, Dominique

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36

Abstract: An extracorporeal blood treatment apparatus comprises a blood treatment device (2), an extracorporeal blood circuit, a blood pump (8) configured to be coupled to a blood withdrawal line (6) of the extracorporeal blood circuit. A closed fluid line (10) is connected to an inlet port (4a) and to an outlet port (4b) of a fluid chamber (4) of the blood treatment device (2), wherein the closed fluid line (10) together with the fluid chamber (4) forms a recirculation loop. An evacuation line (15) departs from the closed fluid line (10). A warming device (13) and a recirculation pump (17) are coupled or configured to be coupled to the closed fluid line (10). At least one temperature sensor (22) is operative on the extracorporeal blood circuit and it is configured to sense a blood temperature (Tb). A control unit (25), connected to the warming device (13), to the recirculation pump (17) and to the temperature sensor (22), is configured to execute the following procedure: receiving from the temperature sensor (22) at least a signal correlated to the blood temperature (Tb); adjusting the blood temperature (Tb) by controlling at least one of the warming device (13) and the recirculation pump (17).

Abstract translation: 一种体外血液处理设备，包括血液处理装置（2），体外血液回路，血液泵（8），血液泵（8）被配置为与体外血液回路（6）的血液抽取管线 。 封闭的流体管线（10）连接到血液处理装置（2）的流体腔室（4）的入口端口（4a）和出口端口（4b），其中封闭的流体管线（10）与 流体室（4）形成再循环回路。 排出管线（15）从封闭流体管线（10）出发。 加温装置（13）和再循环泵（17）联接或构造成联接到封闭流体管线（10）。 至少一个温度传感器（22）在体外血液回路上操作并且被配置为感测血液温度（Tb）。 连接到加温装置（13），再循环泵（17）和温度传感器（22）的控制单元（25）被配置为执行以下过程：从温度传感器（22）接收至少一个 与血液温度（Tb）相关的信号; 通过控制加温装置（13）和再循环泵（17）中的至少一个来调整血液温度（Tb）。

公开(公告)号：WO2010029401A3

公开(公告)日：2010-03-18

申请号：PCT/IB2009/006763

申请日：2009-09-04

Applicant: GAMBRO LUNDIA AB ,  POUCHOULIN, Dominique ,  CHEVALLET, Jacques

Inventor： POUCHOULIN, Dominique ,  CHEVALLET, Jacques

IPC: A61M1/14 ,  A61M1/34 ,  A61M1/36

Abstract: A device for blood treatment by extracorporeal circulation including a filter having a first and a second chambers with a semi-permeable membrane, an arterial line connected to the first chamber and associated to a first pump Qb, a venous line out from the first chamber, a first pre-infusion line (109) connected to a citrate container and associated to a second pump Qpre1, a first post-infusion line connected to a calcium solution container associated to a third pump Qpost1, an effluent line at the outlet of the second chamber connected to a drain and associated to a fourth pump Qeff, a CPU including first means programmed to receive the signals output by at least one of the pumps and second means programmed to control third post-infusion pump Qpost1 (121) as a function of the flow rate Qb, Qeff, and Qpre1.

公开(公告)号：WO2022096389A1

公开(公告)日：2022-05-12

申请号：PCT/EP2021/080102

申请日：2021-10-29

Applicant: GAMBRO LUNDIA AB

Inventor： POUCHOULIN, Dominique

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  G16H20/40

Abstract: A CRRT apparatus comprising a control unit configured to execute a flow-rate setup procedure by receiving a patient prescription comprising clinical prescription parameters, by allowing entry of a set value for a prescribed dialysis dose (Dset) to be delivered, and of a target value for a parameter (nNBL; CpHCO3_PAT) indicative of a steady state acid-base balance in the blood of the patient who has to undergo a CRRT blood treatment, and by determining operating parameters calculating a set value of relevant fluid flow rates including one or more of a fluid flow rate (Qcit) through the anticoagulant infusion line, a fluid flow rate (QPBP) through the PBP infusion line, a fluid flow rate (Qrep.pre) through the pre-dilution infusion line, a fluid flow rate (Qrep.post) through the post-dilution infusion line, a fluid flow rate (QHCO3) through the post-dilution bicarbonate infusion line, a fluid flow rate (Qca) through the ion balancing infusion line, a blood fluid flow rate (Qb) through the extracorporeal blood circuit, a fluid flow rate (Qdial) through the dialysis liquid supply line, and a fluid flow rate (Qeff) through the effluent fluid line, wherein calculating the set value of the fluid flow rates is based at least on the set value of the prescribed dialysis dose (Dset) and on the target value for the parameter (nNBL; CpHCO3_PAT) indicative of a steady state acid-base balance in the blood.

公开(公告)号：WO2021004855A1

公开(公告)日：2021-01-14

申请号：PCT/EP2020/068514

申请日：2020-07-01

Applicant: GAMBRO LUNDIA AB

Inventor： POUCHOULIN, Dominique

IPC: A61M1/16 ,  A61M1/36

Abstract: A method for determining water losses in a membrane gas exchanger of an apparatus for extracorporeal treatment of blood, comprises: obtaining a sweep gas flow rate (Q gas ) in a gas side of a membrane gas exchanger (19); obtaining a water saturation content (C saturation_out ) at a gas outlet (19d) of the membrane gas exchanger (19); calculating the water losses (Q eccor ) as a function at least of the sweep gas flow rate (Q gas ) and the water saturation content (C saturation_out ).

公开(公告)号：WO2018206718A1

公开(公告)日：2018-11-15

申请号：PCT/EP2018/062135

申请日：2018-05-09

Applicant: GAMBRO LUNDIA AB

Inventor： POUCHOULIN, Dominique ,  NISIPEANU, Eugen

IPC: A61M1/14 ,  A61M1/36 ,  A61M5/44 ,  A61F7/00 ,  F28F3/12

Abstract: A container for warming fluids, the container comprising an inlet port, an outlet port, and a fluid conduit configured for putting the inlet port in fluid communication with the outlet port and comprising one or more deflection sections. The fluid conduit has a non-constant maximum width in a direction of fluid flow through the fluid conduit. At least one of the one or more deflection sections further comprises an entry section and an exit section, each respective exit section being arranged downstream, in the direction of fluid flow, from each respective entry section. The maximum width of the fluid conduit decreases along the direction of fluid flow through the entry section over a first distance and the maximum width of the fluid conduit increases along the direction of fluid flow through the exit section over a second distance, the first distance and the second distance being different from one another. An apparatus for warming medical fluids including the container and an extracorporeal blood circuit including the container are also provided. An extracorporeal blood treatment apparatus including the apparatus for warming medical fluids and/or the extracorporeal blood circuit is also provided.

公开(公告)号：WO2013144793A1

公开(公告)日：2013-10-03

申请号：PCT/IB2013/052275

申请日：2013-03-22

Applicant: GAMBRO LUNDIA AB

Inventor： POUCHOULIN, Dominique

IPC: A61M1/16 ,  A61M1/34

CPC classification number: A61M1/1647 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1643 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/3413 ,  A61M1/3434 ,  A61M1/3441 ,  A61M1/3451 ,  A61M1/361 ,  A61M1/3638 ,  A61M2205/18 ,  A61M2205/3334 ,  A61M2205/3393 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52

Abstract: An apparatus for extracorporeal treatment of blood (1) comprising a filtration unit (2), a blood withdrawal line (6), a blood return line (7), an effluent fluid line (13), a pre and/or post-dilution fluid line (15, 25) connected to the blood withdrawal line, and a dialysis fluid line. Pumps (17, 18, 21, 22, 27) act on the fluid lines for regulating the flow of fluid. A control unit (10) is configured to periodically calculate a new value for the patient fluid removal rate to be imposed on an ultrafiltration actuator in order to keep a predefined patient fluid removal rate across a reference time interval irrespective of machine down times.

Abstract translation: 一种用于血液体外处理的装置（1），包括过滤单元（2），抽血管线（6），血液回流管线（7），流出液体管线（13），前和/或后稀释 连接到抽血管线的流体管线（15,25）和透析流体管线。 泵（17,18,21,22,27）作用于用于调节流体流动的流体管线。 控制单元（10）被配置为周期性地计算要施加在超滤致动器上的患者流体去除速率的新值，以便在参考时间间隔内保持预定的患者流体去除率，而与机器停机时间无关。

公开(公告)号：WO2019015961A1

公开(公告)日：2019-01-24

申请号：PCT/EP2018/068063

申请日：2018-07-04

Applicant: GAMBRO LUNDIA AB

Inventor： POUCHOULIN, Dominique

IPC: A61M1/36 ,  A61M1/34

Abstract: An extracorporeal blood treatment apparatus comprises: a blood treatment device (2); an extracorporeal blood circuit comprising a blood withdrawal line (6) and a blood return line (7) coupled to the extracorporeal blood treatment device (2), wherein the blood return line (7) presents a heating zone (14) coupled or configured to be coupled to a blood warmer (15); a blood pump (6) configured to be coupled to a pump section of the blood withdrawal line (6); at least a post-infusion line (13, 13') connected to the blood return line (7) upstream of the heating zone (14); an air trapping device (9) placed on the blood return line (7) upstream of the heating zone (14).

公开(公告)号：WO2016041745A1

公开(公告)日：2016-03-24

申请号：PCT/EP2015/069497

申请日：2015-08-26

Applicant: GAMBRO LUNDIA AB

Inventor： POUCHOULIN, Dominique

IPC: A61M1/36

CPC classification number: A61M1/369 ,  A61M1/1629 ,  A61M1/166 ,  A61M2205/3372 ,  A61M2205/505 ,  A61M2205/52

Abstract: An extracorporeal blood treatment apparatus (1) comprising a control unit (10) connectable to a blood warming device (200). The apparatus (1) comprises: an extracorporeal blood circuit (100) and at least one infusion line (15, 21, 25) connected to the extracorporeal blood circuit (100). A control unit (10) is configured to execute the following procedure: receiving a first value representative of a desired blood temperature (T des ) at an end (70) of a blood return line (7) configured to be connected to a venous vascular access of a patient (P); receiving at least a first signal relating to at least a flow rate (Q PBP , Q REP1 , Q REP2 ) of an infusion fluid in the at least one infusion line (15, 21, 25); calculating a set point value of an operating parameter (Τ OUT ; P w ) to be imposed on the warming device (200) configured to heat a blood heating zone (H) of the extracorporeal blood circuit (100) in order to maintain the desired blood temperature (T des ) at the end (70) of the blood return line (7). The set point is calculated based on input parameters comprising: at least the first value representative of the desired blood temperature (T des ) and at least one selected in the group of: the first signal (Q REPI , Q PBP , Q REP2 ) and a second value representative of a temperature ( T REP1 , T PBP , T REP2 ) of the at least one infusion fluid in the at least one infusion line (15, 21, 25).

Abstract translation: 一种体外血液处理装置（1），包括可连接到血液加温装置（200）的控制单元（10）。 装置（1）包括：体外血液回路（100）和连接到体外血液回路（100）的至少一个输注管线（15,21,25）。 控制单元（10）被配置为执行以下过程：在构造成连接到静脉血管通路的血液回流管线（7）的端部（70）处接收代表期望血液温度（Tdes）的第一值 的患者（P）; 至少接收与所述至少一个输注管线（15,21,25）中的输液的至少流量（QPBP，QREP1，QREP2）有关的第一信号; 计算施加在被配置为加热体外血液回路（100）的血液加热区域（H）的加温装置（200）上的操作参数（TOUT; Pw）的设定值，以便维持所需的血液温度 （7）的末端（70）处的（Tdes）。 基于输入参数计算设定点，包括：至少代表期望血液温度（Tdes）的第一值和在第一信号（QREPI，QPBP，QREP2）和第二值代表中选择的至少一个 在所述至少一个输注管线（15,21,25）中的所述至少一个输注液体的温度（TREP1，TPBP，TREP2）。