公开(公告)号：WO2017144440A2

公开(公告)日：2017-08-31

申请号：PCT/EP2017/053874

申请日：2017-02-21

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： GEBAUER, Klaus ,  MYGAPULA, Sudheer ,  KARMARKAR, Nachiket ,  ARUMUGAM, Sasikumar ,  HV, Bashkar ,  VERNEKAR, Ajit, S. ,  MAIYA, Nityananda ,  MOHAN, Prashanth, Hosabettu ,  NUTALAPATI, Sasi, Kumar ,  HINDUPUR, Sameera, Simha ,  HEGDE, Shashidhar

IPC: B01D61/12 ,  B01D61/22 ,  F16K7/06 ,  F16K7/07 ,  F16K7/16

CPC classification number: B01D61/12 ,  B01D61/22 ,  B01D2311/04 ,  B01D2311/08 ,  B01D2311/14 ,  B01D2313/18 ,  F16K7/04 ,  F16K7/06 ,  F16K7/07 ,  G05D16/00

Abstract: The invention discloses a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a length of flexible tubing to a regulator valve (1; 101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer (22) adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer (39) adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer (40) adapted to measure a pressure at a permeate outlet (36) of the crossflow filter, and a control unit (23) electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP = (P inlet + P outlet )/2 - P perm corresponds to a predetermined TMP value or to an interval between two predetermined TMP values, wherein P inlet is a pressure reading from the second pressure transducer, P outlet is a pressure reading from the first pressure transducer and P perm is a pressure reading from the third pressure transducer.

Abstract translation: 本发明公开了一种控制横流过滤装置中的跨膜压力（TMP）的方法，其包括以下步骤：a）提供横流过滤装置，所述横流过滤装置包括泵（21），所述泵经由滞留物 横向流动过滤器（32）的隔室（33）和一段柔性管道连接到作用在柔性管道上的调节阀（1; 101），其中调节阀是高精度夹管阀。 该设备还包括适于测量滞留物隔室和调节阀之间的压力的第一压力换能器（22），适于测量泵和滞留物隔室之间的压力的第二压力换能器（39）以及第三压力换能器（ 40），其适于测量所述错流过滤器的渗透物出口（36）处的压力;以及控制单元（23），其与所述调节阀，所述第一，第二和第三压力传感器以及可选地与所述泵电或电磁连接; b）通过所述第二压力传感器通过所述泵通过所述一段柔性管，所述第一压力传感器和所述调节器阀，通过所述滞留物室泵送液体; c）用控制单元控制调节阀，使得通过公式（I）计算的TMP = TMP =（P +入口+ P出口）/ 2 -P _{perm 对应于预定的TMP值或者对应于两个预定TMP值之间的间隔，其中P in入口是来自第二压力换能器的压力读数，P out >是来自第一压力传感器的压力读数，而P perm是来自第三压力传感器的压力读数。}

公开(公告)号：WO2020016396A1

公开(公告)日：2020-01-23

申请号：PCT/EP2019/069465

申请日：2019-07-19

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： MOHAN, Prashanth, Hosabettu ,  VERNEKAR, Ajit, S. ,  PAUL, Praveen ,  MADHAVAN NAIR, Krishnadev ,  BHAT, Manjunath

IPC: F16K11/044 ,  F16K11/056 ,  F16K31/06

Abstract: A valve (100) for a bioprocess liquid apparatus (199) comprises tubular sections (101, 102, 103) inside which valve seat means (155) are arranged. A plunger arrangement (150) is configured to selectively interact with the valve seat means to close and open the tubular sections in response to a magnetic field provided by solenoid arrangements (104, 105), the solenoid arrangements being arranged at the bioprocess liquid apparatus. A flow path device comprising such a valve and a bioprocess liquid apparatus and a method of handling a bioprocess liquid are also disclosed.

公开(公告)号：WO2017144440A3

公开(公告)日：2017-08-31

申请号：PCT/EP2017/053874

申请日：2017-02-21

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： GEBAUER, Klaus ,  MYGAPULA, Sudheer ,  KARMARKAR, Nachiket ,  ARUMUGAM, Sasikumar ,  HV, Bashkar ,  VERNEKAR, Ajit, S. ,  MAIYA, Nityananda ,  MOHAN, Prashanth, Hosabettu ,  NUTALAPATI, Sasi, Kumar ,  HINDUPUR, Sameera, Simha ,  HEGDE, Shashidhar

IPC: B01D61/12 ,  B01D61/22 ,  F16K7/06 ,  F16K7/07 ,  F16K7/16 ,  G05D16/00

Abstract: The invention discloses embodiments of different high precision pinch control valves having an accuracy in the micron range and a method of controlling a transmembrane pressure (TMP) in a crossflow filtration apparatus, comprising the steps of: a) providing a crossflow filtration apparatus comprising a pump (21) fluidically connected via a retentate compartment (33) of a crossflow filter (32) and a length of flexible tubing to a regulator valve (1;101) acting on the flexible tubing, wherein the regulator valve is a high precision pinch valve. The apparatus further comprises a first pressure transducer (22) adapted to measure a pressure between the retentate compartment and the regulator valve, a second pressure transducer (39) adapted to measure a pressure between the pump and the retentate compartment and a third pressure transducer (40) adapted to measure a pressure at a permeate outlet (36) of the crossflow filter, and a control unit (23) electrically or electromagnetically connected to said regulator valve, the first, second and third pressure transducers and optionally to the pump; b) pumping a liquid with the pump via the second pressure transducer, through the retentate compartment via the length of flexible tubing, the first pressure transducer and the regulator valve; c) controlling the regulator valve with the control unit, such that a TMP calculated by formula (I) TMP = (P inlet + P outlet )/2 - P perm (I)

Abstract translation: 本发明公开了具有微米范围内的精度的不同高精度夹持控制阀的实施例和控制横流过滤装置中的跨膜压力（TMP）的方法，其包括以下步骤：a） 提供横流过滤设备，所述横流过滤设备包括经由错流过滤器（32）的滞留室（33）和一定长度的柔性管流体连接到作用在柔性管上的调节阀（1; 101）的泵（21），其中， 调节阀是一种高精度夹管阀。 该设备还包括适于测量滞留物隔室和调节阀之间的压力的第一压力换能器（22），适于测量泵和滞留物隔室之间的压力的第二压力换能器（39）以及第三压力换能器（ 40），其适于测量所述错流过滤器的渗透物出口（36）处的压力;以及控制单元（23），其与所述调节阀，所述第一，第二和第三压力传感器以及可选地与所述泵电或电磁连接; b）通过所述第二压力传感器通过所述泵通过所述一段柔性管，所述第一压力传感器和所述调节器阀，通过所述滞留物室泵送液体; c）用控制单元控制调节阀，使得通过公式（I）计算的TMP = TMP =（P +入口+ P出口）/ 2 -P _{perm （I）}

公开(公告)号：WO2017097604A1

公开(公告)日：2017-06-15

申请号：PCT/EP2016/078760

申请日：2016-11-25

Applicant: GE HEALTHCARE BIO-SCIENCES AB

Inventor： SINGH, Amit, Kumar ,  GEBAUER, Klaus ,  DATTA, Supti ,  LIDERFELT, Jakob ,  KARMARKAR, Nachiket ,  VERNEKAR, Ajit, S. ,  OLSSON, Mats ,  RAJAN, Thiyaga ,  SHARMA, Amit, K. ,  NUTALAPATI, Sasi, Kumar ,  LUNDSTROM, Fredrik ,  NEFF, Jean Pierre

IPC: B01D61/18 ,  B01D15/00

CPC classification number: B01D61/18 ,  B01D15/00 ,  B01D2313/18 ,  B01D2313/58

Abstract: The invention discloses a first unit (1) for treatment of a bioprocess liquid comprising a first lateral face (2), a second lateral face (3) and a front face (4) which meets the two said lateral faces. The front face comprises: a plurality of valves (7) adapted to receive and act upon one or more legs (8) of a disposable flow path (6); optionally one or more pumps (10) adapted to receive and act upon one or more legs of the disposable flow path; optionally one or more sensors (11) adapted to receive and to measure one or more parameters in one or more legs of the disposable flow path; wherein the plurality of valves and optional pumps and sensors are vertically offset from each other to give one or more legs of a disposable flow path received by said valves and optional pumps and sensors a slope of at least 3.0 degrees from the horizontal plane (h).

Abstract translation: 本发明公开了用于处理生物过程液体的第一单元（1），所述生物过程液体包括第一侧面（2），第二侧面（3）和与所述两个侧面（3）相遇的前表面（4） 所述侧面。 该正面包括：多个阀（7），其适于接收并作用于一次性流动路径（6）的一个或多个腿（8）; 任选地一个或多个泵（10），其适于接收并作用于所述一次性流动路径的一个或多个腿; 任选地一个或多个传感器（11），其适于接收并测量所述一次性流动路径的一个或多个腿中的一个或多个参数; 其中所述多个阀和可选的泵和传感器彼此垂直偏移以给出由所述阀和可选的泵和传感器接收的一次性流动路径的一个或多个腿，所述一次或多次腿与所述水平面（h）至少成3.0度的斜率，