公开(公告)号：WO2013162456A1

公开(公告)日：2013-10-31

申请号：PCT/SE2013/050449

申请日：2013-04-24

Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB

Inventor： CHEN, Lin ,  HOCHLEITNER, Klaus ,  HOU, Rong ,  LU, Lianghua ,  YANG, Jianjun

IPC: G01N33/558

CPC classification number: G01N33/558 ,  G01N2333/525

Abstract: A method comprises: providing a test strip having a sample portion, a conjugation portion comprising a control protein bindable to a fragment crystallizable (Fc) portion of an antibody or a fusion protein and a label conjugated with the control protein, a detection portion comprising an antigen specific for the antibody or the fusion protein, and a control portion comprising a control antibody of the control protein; contacting a sample solution comprising the antibody or the fusion protein with the sample portion; allowing the sample solution to migrate from the sample portion through the control portion; detecting an intensity of a signal of the detection portion; and determining the concentration of the antibody or the fusion protein in the sample solution using a formula in which the concentration of the antibody or the fusion protein is a function of the intensity of the signal.

Abstract translation: 一种方法包括：提供具有样品部分的测试条，包含可与抗体或融合蛋白的可结晶（Fc）部分结合的对照蛋白的缀合部分和与对照蛋白质结合的标记，检测部分包含 抗体或融合蛋白特异的抗原，以及包含对照蛋白的对照抗体的对照部分; 使包含抗体或融合蛋白的样品溶液与样品部分接触; 允许样品溶液从样品部分迁移通过控制部分; 检测所述检测部分的信号的强度; 并使用其中抗体或融合蛋白的浓度是信号强度的函数的公式确定样品溶液中抗体或融合蛋白的浓度。

公开(公告)号：WO2016162143A1

公开(公告)日：2016-10-13

申请号：PCT/EP2016/054280

申请日：2016-03-01

Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB

Inventor： LU, Lianghua ,  CHEN, Lin ,  GAO, Jie ,  PAN, Zhida ,  PENG, Wenqing ,  SODERMAN, Tobias, E.

IPC: B01J13/00 ,  B01J20/26 ,  B01J20/28

CPC classification number: B01J20/24 ,  B01J4/002 ,  B01J13/00 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28019 ,  B01J20/281 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3007 ,  B01J20/3085 ,  B01J2220/52 ,  C07K1/16 ,  C07K1/18 ,  C07K1/22

Abstract: A method includes spraying a liquid including polymer and a gas substantially inert to the liquid respectively from a first and second orifice of a nozzle into air to form mist of beads. The beads then are collected with a collecting medium at a temperature in a range from about -10˚C to about 80˚C. The collecting medium includes at least one of water and alcohols.

Abstract translation: 一种方法包括将包括聚合物的液体和基本上惰性的气体分别从喷嘴的第一和第二孔口喷射到空气中以形成珠雾。 然后在约-10℃至约80℃的温度下用收集介质收集珠粒。 收集介质包括水和醇中的至少一种。

公开(公告)号：WO2014084789A1

公开(公告)日：2014-06-05

申请号：PCT/SE2013/051404

申请日：2013-11-28

Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB

Inventor： CHEN, Lin ,  DANIELSSON, Åke ,  MALMQUIST, Gunnar ,  LU, Lianghua ,  HOU, Rong

IPC: G01N33/53

CPC classification number: G01N33/558

Abstract: A method comprises: contacting a sample solution comprising a tagged protein with a labeled binder bindable to a tag of the tagged protein; contacting the sample solution with a binding material bindable to the labeled binder which is not bound with the tag; and determining a concentration of the tagged protein in the sample solution according to a signal change before and after contacting the sample solution with the binding material. An associated apparatus is also described.

Abstract translation: 一种方法包括：将包含标记蛋白质的样品溶液与可与标记蛋白质的标签结合的标记的结合物接触; 使样品溶液与可与标签结合的标记粘合剂的结合材料接触; 以及根据样品溶液与粘合材料接触之前和之后的信号变化来确定样品溶液中标记的蛋白质的浓度。 还描述了相关联的装置。