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    METHOD AND APPARATUS FOR DETECTION OF TAGGED PROTEIN
    2.
    发明申请
    METHOD AND APPARATUS FOR DETECTION OF TAGGED PROTEIN 审中-公开
    用于检测标记蛋白的方法和装置

    公开(公告)号：WO2014084789A1

    公开(公告)日：2014-06-05

    申请号：PCT/SE2013/051404

    申请日：2013-11-28

    Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB

    Inventor： CHEN, Lin ,  DANIELSSON, Åke ,  MALMQUIST, Gunnar ,  LU, Lianghua ,  HOU, Rong

    IPC: G01N33/53

    CPC classification number: G01N33/558

    Abstract: A method comprises: contacting a sample solution comprising a tagged protein with a labeled binder bindable to a tag of the tagged protein; contacting the sample solution with a binding material bindable to the labeled binder which is not bound with the tag; and determining a concentration of the tagged protein in the sample solution according to a signal change before and after contacting the sample solution with the binding material. An associated apparatus is also described.

    Abstract translation: 一种方法包括：将包含标记蛋白质的样品溶液与可与标记蛋白质的标签结合的标记的结合物接触; 使样品溶液与可与标签结合的标记粘合剂的结合材料接触; 以及根据样品溶液与粘合材料接触之前和之后的信号变化来确定样品溶液中标记的蛋白质的浓度。 还描述了相关联的装置。

    METHOD FOR DETECTING CONCENTRATION OF ANTIBODY OR FUSION PROTEIN
    4.
    发明申请
    METHOD FOR DETECTING CONCENTRATION OF ANTIBODY OR FUSION PROTEIN 审中-公开
    检测抗体或融合蛋白浓度的方法

    公开(公告)号：WO2013162456A1

    公开(公告)日：2013-10-31

    申请号：PCT/SE2013/050449

    申请日：2013-04-24

    Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB

    Inventor： CHEN, Lin ,  HOCHLEITNER, Klaus ,  HOU, Rong ,  LU, Lianghua ,  YANG, Jianjun

    IPC: G01N33/558

    CPC classification number: G01N33/558 ,  G01N2333/525

    Abstract: A method comprises: providing a test strip having a sample portion, a conjugation portion comprising a control protein bindable to a fragment crystallizable (Fc) portion of an antibody or a fusion protein and a label conjugated with the control protein, a detection portion comprising an antigen specific for the antibody or the fusion protein, and a control portion comprising a control antibody of the control protein; contacting a sample solution comprising the antibody or the fusion protein with the sample portion; allowing the sample solution to migrate from the sample portion through the control portion; detecting an intensity of a signal of the detection portion; and determining the concentration of the antibody or the fusion protein in the sample solution using a formula in which the concentration of the antibody or the fusion protein is a function of the intensity of the signal.

    Abstract translation: 一种方法包括：提供具有样品部分的测试条，包含可与抗体或融合蛋白的可结晶（Fc）部分结合的对照蛋白的缀合部分和与对照蛋白质结合的标记，检测部分包含 抗体或融合蛋白特异的抗原，以及包含对照蛋白的对照抗体的对照部分; 使包含抗体或融合蛋白的样品溶液与样品部分接触; 允许样品溶液从样品部分迁移通过控制部分; 检测所述检测部分的信号的强度; 并使用其中抗体或融合蛋白的浓度是信号强度的函数的公式确定样品溶液中抗体或融合蛋白的浓度。

    METHOD AND SYSTEM FOR FORMING POLYMER MICROPARTICLES
    5.
    发明申请
    METHOD AND SYSTEM FOR FORMING POLYMER MICROPARTICLES 审中-公开
    形成聚合物微粒的方法和系统

    公开(公告)号：WO2018001865A1

    公开(公告)日：2018-01-04

    申请号：PCT/EP2017/065426

    申请日：2017-06-22

    Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE BIO-SCIENCES AB

    Inventor： CHEN, Lin ,  GAO, Jie ,  HUANG, Qiongqiong

    IPC: B01J13/04

    Abstract: A method for forming polymer microparticles is disclosed. The method comprises spraying a liquid comprising a thermally-gelling polymer from a first orifice of a nozzle into air to form gelled microparticles, and collecting the gelled microparticles with a collecting device. The nozzle is positioned to have a central axis of the first orifice at a tilt angle in a range from about 10 degrees to about 170 degrees relative to a direction of gravity. The collecting device comprises at least two collecting units at different distances from the first orifice of the nozzle in a horizontal direction perpendicular to the direction of gravity. Each of the collecting unit is loaded with a liquid collecting medium. A system for forming polymer microparticles is also disclosed.

    Abstract translation: 公开了形成聚合物微粒的方法。 该方法包括将包含热凝胶聚合物的液体从喷嘴的第一孔口喷射到空气中以形成凝胶化的微粒，并且用收集装置收集凝胶化的微粒。 喷嘴被定位成使第一孔的中心轴线相对于重力方向处于约10度至约170度的范围内的倾斜角度。 该收集装置包括至少两个收集单元，该至少两个收集单元在垂直于重力方向的水平方向上与喷嘴的第一孔口不同距离。 每个收集单元装有液体收集介质。 还公开了用于形成聚合物微粒的系统。

    FILTER ELEMENT AND A METHOD OF MANUFACTURING THEREOF
    7.
    发明申请
    FILTER ELEMENT AND A METHOD OF MANUFACTURING THEREOF 审中-公开
    滤波元件及其制造方法

    公开(公告)号：WO2017112478A1

    公开(公告)日：2017-06-29

    申请号：PCT/US2016/066537

    申请日：2016-12-14

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： YANG, Linglu ,  HUANG, Jie ,  PENG, Yun ,  CHEN, Lin ,  LU, Su

    IPC: B01D63/10 ,  B01D69/10

    CPC classification number: B01D63/103 ,  B01D63/10 ,  B01D2323/42

    Abstract: The present invention relates to a filter element and a method for manufacturing thereof. The method comprises: Providing the core tube; and rolling a membrane around the core tube. The membrane comprises a porous substrate and a filter layer on top of the porous substrate. The present invention also relates to the corresponding filter element. The filter element relating to the present invention is able to accommodate more membranes inside the same volume, resulting in high throughput and high salt rejection.

    Abstract translation: 过滤元件及其制造方法技术领域本发明涉及一种过滤元件及其制造方法。 该方法包括：提供芯管; 并围绕芯管滚动膜。 该膜包含多孔基材和位于多孔基材顶部的过滤层。 本发明还涉及相应的过滤器元件。 涉及本发明的过滤元件能够在相同体积内容纳更多的膜，从而产生高通量和高脱盐率。

    ION-EXCHANGE DEVICE AND REGENERATION METHOD OF ION-EXCHANGE METERIAL THEREOF
    8.
    发明申请
    ION-EXCHANGE DEVICE AND REGENERATION METHOD OF ION-EXCHANGE METERIAL THEREOF 审中-公开
    离子交换装置及其交换材料的再生方法

    公开(公告)号：WO2010077448A1

    公开(公告)日：2010-07-08

    申请号：PCT/US2009/064397

    申请日：2009-11-13

    Applicant: GENERAL ELECTRIC COMPANY ,  XIONG, Rihua ,  CAI, Wei ,  ZHENG, Liping ,  YANG, Hai ,  LU, Su ,  DENG, Zhigang ,  CHEN, Lin

    Inventor： XIONG, Rihua ,  CAI, Wei ,  ZHENG, Liping ,  YANG, Hai ,  LU, Su ,  DENG, Zhigang ,  CHEN, Lin

    IPC: C02F1/469

    CPC classification number: C02F1/4691 ,  B01J49/30 ,  B82Y30/00 ,  C02F2001/46128 ,  C02F2001/46133 ,  C02F2001/46138 ,  C02F2001/46161 ,  C02F2303/16 ,  C02F2305/08 ,  H01M2008/1095

    Abstract: An electrochemical device (10) comprises an electrochemical cell (11). The electrochemical cell comprises a composite cation-exchange member (12) including a conductive e base and a cation-exchange material in physical contact with the conductive base, a composite anion-exchange member (14) including a conductive base and an anion-exchange material in physical contact with the conductive base: and a compartment (16) between the composite cation-exchange and anion-exchange members The compartment composes an inlet for introducing a feed stream, and an outlet for exiting of an output stream out of the compartment The electrochemical device comprises a control device (17) configured to transmit an electrical current to {he composite cat) on -exchange and anion-exchange members at a regeneration stage in a manner that the conductive base on the composite cation-exchange member loses electrons and the conductive base on the composite anion-exchange member gains electrons.

    Abstract translation: 电化学装置（10）包括电化学电池（11）。 所述电化学电池包括复合阳离子交换构件（12），所述复合阳离子交换构件（12）包括与导电性基底物理接触的导电性e碱和阳离子交换材料，复合阴离子交换构件（14），其包含导电性碱和阴离子交换 与导电基体物理接触的材料和复合阳离子交换和阴离子交换构件之间的隔间（16）隔室构成用于引入进料流的入口和用于将输出流离开室的出口 电化学装置包括控制装置（17），其被配置为在再生阶段以复合阳离子交换部件上的导电性基底损失电子的方式在交换器和阴离子交换部件上传输电流 并且复合阴离子交换部件上的导电基体获得电子。

    IMPROVEMENTS IN THE RECOVERY OF NUCLEIC ACIDS FROM SOLID SUPPORTS
    9.
    发明申请
    IMPROVEMENTS IN THE RECOVERY OF NUCLEIC ACIDS FROM SOLID SUPPORTS 审中-公开

    公开(公告)号：WO2018215375A1

    公开(公告)日：2018-11-29

    申请号：PCT/EP2018/063234

    申请日：2018-05-18

    Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE LIMITED

    Inventor： PATEL, Paresh Lakhubhai ,  CHEN, Lin ,  SCHWANDT, Melissa ,  REAMS, Koya ,  HANSEN, Thomas

    IPC: C12N15/10

    Abstract: Disclosed is a method for the recovery of nucleic acids from a solid support, the method comprising the steps, in any suitable order, of: a) providing a solid support at least a region of which is absorbent and impregnated with a chaotropic agent; b) combining a biological sample, possibly including nucleic acids, with the region; c) washing the region in a washing buffer solution; d) simultaneously heating and agitating the region in a further buffer solution; e) separating the region from the further buffer solution; f) extracting at least a portion of any remaining further buffer solution from the region to provide an extracted buffer solution; g) combining the further buffer solution and the extracted buffer solution portion; and h) subsequently processing the combined buffer solutions in order to amplify any nucleic acids in said combined solution. Hardware suitable for implementing the above method and a kit of parts is disclosed also

    METHOD AND APPARATUS FOR ISOLATING NUCLEIC ACIDS
    10.
    发明申请
    METHOD AND APPARATUS FOR ISOLATING NUCLEIC ACIDS 审中-公开
    分离核酸的方法和装置

    公开(公告)号：WO2013096575A1

    公开(公告)日：2013-06-27

    申请号：PCT/US2012/070862

    申请日：2012-12-20

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： CHEN, Lin ,  ZHANG, Bing ,  HOCHLEITNER, Klaus ,  HOU, Rong ,  WANG, Yanju

    IPC: C07H21/00

    CPC classification number: C12N15/1017 ,  B01J20/103 ,  B01J20/28023 ,  B01J20/28038 ,  B01J20/281 ,  B01J2220/82 ,  C07H1/06 ,  C07H1/08 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04

    Abstract: A method comprises: sorbing a sample solution comprising nucleic acids to a sample receiving portion of a quartz fiber filter by contacting the sample solution with the sample receiving portion; and washing the sample receiving portion while keeping most of nucleic acids around the sample receiving portion by flowing a wash solution through the sample receiving portion under a wicking force directed away from the sample receiving portion. An associated apparatus is also provided.

    Abstract translation: 一种方法包括：通过使样品溶液与样品接收部分接触，将包含核酸的样品溶液吸附到石英纤维过滤器的样品接收部分; 并且通过在远离样品接收部分的芯吸力下使洗涤溶液流过样品接收部分，同时将样品接收部分周围的大部分核酸保持在一起而洗涤样品接收部分。 还提供了一种相关联的装置。

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