公开(公告)号：WO1998004693A2

公开(公告)日：1998-02-05

申请号：PCT/US1997012883

申请日：1997-07-23

Applicant: GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth

Inventor： GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth ,  MCCOY, John, M. ,  LEVALLIE, Edward, R. ,  RACIE, Lisa, A. ,  MERBERG, David ,  TREACY, Maurice ,  EVANS, Cheryl ,  SPAULDING, Vikki

IPC: C12N15/12

CPC classification number: C07K14/47 ,  Y10S530/85 ,  Y10S530/851

Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.

公开(公告)号：WO1986003520A1

公开(公告)日：1986-06-19

申请号：PCT/US1985002405

申请日：1985-12-03

Applicant: GENETICS INSTITUTE, INC. ,  FRITSCH, Edward ,  HEWICK, Rodney, M. ,  JACOBS, Kenneth

Inventor： GENETICS INSTITUTE, INC.

IPC: C12P21/00

CPC classification number: C07K14/505 ,  C12N15/85 ,  C12N2800/108 ,  C12N2830/00 ,  C12N2830/002 ,  C12N2830/42 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/44

Abstract: Cloned genes for human erythropoietin (EPO) obtained from human fetal liver that provide surprisingly high levels of expression. Also described is the expression of said genes in vitro to produce active human EPO.

Abstract translation: 从人胎肝获得的人促红细胞生成素（EPO）的克隆基因提供惊人的高水平表达。 还描述了所述基因在体外的表达以产生活性人EPO。

公开(公告)号：WO1998004695A1

公开(公告)日：1998-02-05

申请号：PCT/US1997012892

申请日：1997-07-23

Applicant: GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth

Inventor： GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth ,  MCCOY, John, M. ,  LAVALLIE, Edward, R. ,  RACIE, Lisa, A. ,  MERBERG, David ,  TREACY, Maurice ,  SPAULDING, Vikki

IPC: C12N15/12

CPC classification number: C07K14/47

Abstract: Novel polynucleotides and proteins encoded thereby are disclosed.

Abstract translation: 公开了由此编码的新型多核苷酸和蛋白质。

公开(公告)号：WO1999024057A2

公开(公告)日：1999-05-20

申请号：PCT/US1998022574

申请日：1998-10-23

Applicant: GENETICS INSTITUTE, INC.

Inventor： GENETICS INSTITUTE, INC. ,  CELESTE, Anthony, J. ,  WOZNEY, John, M. ,  THIES, Scott, R.

IPC: A61K38/18

CPC classification number: A61K38/1875 ,  C07K14/51 ,  C12N5/0619 ,  C12N2501/155

Abstract: Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.

Abstract translation: 公开了纯化的BMP-11蛋白质及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素，例如用于避孕。 此外，蛋白质可用于诱导和/或维持骨，软骨和/或其它结缔组织和/或神经元组织。

公开(公告)号：WO1998030589A2

公开(公告)日：1998-07-16

申请号：PCT/US1997023506

申请日：1997-12-20

Applicant: GENETICS INSTITUTE, INC.

Inventor： GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth ,  MCCOY, John, M. ,  LAVALLIE, Edward, R. ,  RACIE, Lisa, A. ,  MERBERG, David ,  TREACY, Maurice ,  SPAULDING, Vikki ,  AGOSTINO, Michael, J.

IPC: C07K14/47

CPC classification number: C07K14/47

Abstract: The invention concerns novel polynucleotides and the secreted or transmembrane proteins encoded thereby.

Abstract translation: 本发明涉及新型多核苷酸及其编码的分泌或跨膜蛋白。

公开(公告)号：WO1998020125A1

公开(公告)日：1998-05-14

申请号：PCT/US1997014649

申请日：1997-08-20

Applicant: GENETICS INSTITUTE, INC.

Inventor： GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth ,  MCCOY, John, M. ,  LAVALLIE, Edward, R. ,  RACIE, Lisa, A. ,  MERBERG, David ,  TREACY, Maurice ,  SPAULDING, Vikki

IPC: C12N15/12

CPC classification number: C07K14/47

Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.

Abstract translation: 本发明涉及新的多核苷酸及其编码的蛋白质。

公开(公告)号：WO1997048798A1

公开(公告)日：1997-12-24

申请号：PCT/US1997010439

申请日：1997-06-16

Applicant: GENETICS INSTITUTE, INC.

Inventor： GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth ,  MCCOY, John, M. ,  LAVALLIE, Edward, R. ,  RACIE, Lisa, A. ,  MERBERG, David ,  TREACY, Maurice ,  SPAULDING, Vikki

IPC: C12N15/12

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/52

Abstract: The invention provides a polynucleotide isolated from clone 0276-16 derived from a human dendritic cell cDNA library using methods selective for cDNA encoding secreted proteins.

Abstract translation: 本发明提供了使用从编码分泌蛋白质的cDNA选择性的方法从人树突状细胞cDNA文库衍生的克隆0276-16中分离的多核苷酸。

公开(公告)号：WO1997040151A2

公开(公告)日：1997-10-30

申请号：PCT/US1997006125

申请日：1997-04-14

Applicant: GENETICS INSTITUTE, INC.

Inventor： GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth ,  MCCOY, John, M. ,  RACIE, Lisa, A. ,  LAVALLIE, Edward, R. ,  MERBERG, David ,  SPAULDING, Vikki

IPC: C12N15/12

CPC classification number: C07K14/52 ,  A61K38/00 ,  C07K14/47

Abstract: The invention provides 5 clones G52-24, H1075-1, J59-41, H83-22, J143-1 isolated from a human PBMC cDNA library and one clone M97-2 from a human glioblastoma cell line T98G cDNA library using a method of screening for cDNAs encoding secreted proteins. Determination of the nucleotide sequences and of the deduced amino acid sequences.

Abstract translation: 本发明提供从人PBMC cDNA文库分离的5个克隆G52-24，H1075-1，J59-41，H83-22，J143-1和来自人成胶质细胞瘤细胞系T98G cDNA文库的一个克隆M97-2，使用 筛选编码分泌蛋白的cDNA。 确定核苷酸序列和推断的氨基酸序列。

公开(公告)号：WO1997040146A1

公开(公告)日：1997-10-30

申请号：PCT/US1996005727

申请日：1996-04-24

Applicant: GENETICS INSTITUTE, INC.

Inventor： GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth

IPC: C12N15/10

CPC classification number: C12N9/2408 ,  C07K2319/00 ,  C12N15/1051

Abstract: A novel method for isolating novel secreted mammalian proteins is described in which mammalian secretory leader sequences are detected using the yeast invertase gene as a reporter system.

Abstract translation: 描述了分离新分泌的哺乳动物蛋白质的新方法，其中使用酵母转化酶基因作为报告系统检测哺乳动物分泌前导序列。

公开(公告)号：WO1997038084A2

公开(公告)日：1997-10-16

申请号：PCT/US1997005682

申请日：1997-04-04

Applicant: GENETICS INSTITUTE, INC.

Inventor： GENETICS INSTITUTE, INC. ,  JACOBS, Kenneth ,  MCCOY, John, M. ,  RACIE, Lisa, A. ,  LAVALLIE, Edward, R. ,  MERBERG, David ,  SPAULDING, Vikki

IPC: C12N00/00

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/52 ,  Y10S530/85 ,  Y10S530/853

Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.

Abstract translation: 公开了新的多核苷酸和由此编码的蛋白质。