公开(公告)号：WO2020037117A1

公开(公告)日：2020-02-20

申请号：PCT/US2019/046644

申请日：2019-08-15

Applicant: GEORGIA TECH RESEARCH CORPORATION

Inventor： FEDOROV, Andrei G. ,  KOTTKE, Peter Arthur ,  CHILMONCZYK, Mason

IPC: G01N1/10 ,  G01N1/38 ,  G01N1/40 ,  F17D3/00

Abstract: The present disclosure provides for analysis systems that are configured to extract a fluid sample from a fluid (e.g., aqueous solution) in a reactor (e.g., bioreactor) at a first rate and then flow the fluid sample to a sensor system at a second rate to analyze the fluid sample. The sensor system can detect the presence and/or concentration of molecules (e.g., biomolecules such as biomarkers (e.g., metabolites, proteins, peptides, cytokines, growth factors, DNA, RNA, lipids) and cells of different types and cell properties, e.g., mechanical stiffness, etc.)). The data obtained can be used by a feedback control system to modify, as needed, the conditions in the reactor to enhance the productively of the reactor.