公开(公告)号：WO2021067781A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/054043

申请日：2020-10-02

Applicant: GEORGIA TECH RESEARCH CORPORATION

Inventor： FEDOROV, Andrei G. ,  KOTTKE, Peter Arthur

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/00

Abstract: Disclosed herein are specimen imaging systems, comprising: a sample stage in a vacuum environment, the sample stage configured to support a specimen; an electron beam generator configured to focus an electron beam on a first predetermined location on the specimen; a nanospray dispenser configured to dispense a nanospray onto a second predetermined location on the specimen; a mass spectrometer; and an extraction conduit configured to extract a plume of charged particles generated as a result of contact between the nanospray and the specimen and deliver the charged particles to the mass spectrometer. The system can create a topological and chemical map of the specimen by analyzing at least a portion of the specimen with a mass spectrometer to determine a chemical composition of the specimen at the second predetermined location and analyzing at least a portion of the specimen with the electron beam to determine a surface topology.

公开(公告)号：WO2014047438A2

公开(公告)日：2014-03-27

申请号：PCT/US2013/060919

申请日：2013-09-20

Applicant: GEORGIA TECH RESEARCH CORPORATION

Inventor： FEDOROV, Andrei G. ,  GREEN, Craig Elkton

IPC: A61N5/06

CPC classification number: A61N5/062 ,  A61N5/0616 ,  A61N2005/007

Abstract: A system for controlling temperatures during medical procedures is disclosed. The system can include a high-thermal conductivity matrix with embedded thermal capacitors. The matrix can be a cream or gel, for example, and can enable the system to be easily applied to the skin, or other area to be treated. The thermal capacitors can include phase change materials, polymers, fats, or other materials that undergo an endothermic physico-chemical transformation above a first predetermined temperature (e.g., room temperature), but below a second predetermined temperature (e.g., the patient's pain threshold). The system can further include one or more thickeners to provide the desired rheological properties for application. The system can also include one or more lubricants to ease some operations during the medical procedure.

Abstract translation: 公开了一种用于在医疗程序期间控制温度的系统。 该系统可以包括具有嵌入式热电容器的高导热性矩阵。 例如，基质可以是乳膏或凝胶，并且可以使系统容易地应用于皮肤或其他待治疗区域。 热电容器可以包括在第一预定温度（例如，室温）以上，但低于第二预定温度（例如，患者的疼痛阈值）的情况下经历吸热物理化学转化的相变材料，聚合物，脂肪或其他材料， 。 该系统可以进一步包括一种或多种增稠剂以提供用于应用的所需流变性质。 该系统还可以包括一种或多种润滑剂，以减轻医疗过程中的一些操作。

公开(公告)号：WO2020037117A1

公开(公告)日：2020-02-20

申请号：PCT/US2019/046644

申请日：2019-08-15

Applicant: GEORGIA TECH RESEARCH CORPORATION

Inventor： FEDOROV, Andrei G. ,  KOTTKE, Peter Arthur ,  CHILMONCZYK, Mason

IPC: G01N1/10 ,  G01N1/38 ,  G01N1/40 ,  F17D3/00

Abstract: The present disclosure provides for analysis systems that are configured to extract a fluid sample from a fluid (e.g., aqueous solution) in a reactor (e.g., bioreactor) at a first rate and then flow the fluid sample to a sensor system at a second rate to analyze the fluid sample. The sensor system can detect the presence and/or concentration of molecules (e.g., biomolecules such as biomarkers (e.g., metabolites, proteins, peptides, cytokines, growth factors, DNA, RNA, lipids) and cells of different types and cell properties, e.g., mechanical stiffness, etc.)). The data obtained can be used by a feedback control system to modify, as needed, the conditions in the reactor to enhance the productively of the reactor.