公开(公告)号：WO2022140390A1

公开(公告)日：2022-06-30

申请号：PCT/US2021/064618

申请日：2021-12-21

申请人： GILEAD SCIENCES, INC.

发明人： BYUN, Daniel H. ,  CAI, Zhenhong R. ,  CANALES, Eda Y. ,  DEBIEN, Laurent P. ,  HANSEN, Timothy R. ,  HUANG, Richard ,  JANSA, Petr ,  LEE, Rick A. ,  LOYER-DREW, Jennifer A. ,  MCFADDEN, Ryan ,  MITCHELL, Michael L. ,  PYUN, Hyung-Jung ,  SAITO, Roland D. ,  SANGI, Michael S. ,  SCHRIER, Adam J. ,  SHATSKIKH, Marina E. ,  TAYLOR, James G. ,  VAN VELDHUIZEN, Joshua J. ,  XU, Lianhong

IPC分类号： C07D401/14 ,  C07D471/04 ,  C07D519/00 ,  A61P35/02 ,  A61K31/437

摘要： The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

公开(公告)号：WO2021222353A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/029557

申请日：2021-04-28

申请人： GILEAD SCIENCES, INC.

发明人： CANALES, Eda Y. ,  CHANG, Weng K. ,  DEBIEN, Laurent P. ,  JANSA, Petr ,  LOYER-DREW, Jennifer A. ,  MARTINEZ, Luisruben P. ,  PERREAULT, Stephane ,  PHILLIPS, Gary B. ,  PYUN, Hyung-Jung ,  SAITO, Roland D. ,  SANGI, Michael S. ,  SCHRIER, Adam J. ,  SHATSKIKH, Marina E. ,  TAYLOR, James G. ,  TREIBERG, Jennifer A. ,  VAN VELDHUIZEN, Joshua J.

IPC分类号： C07D471/18 ,  C07D471/22 ,  C07D487/08 ,  C07D491/22 ,  C07D498/18 ,  C07D498/22 ,  C07D513/18 ,  A61P3/10 ,  A61P7/02 ,  A61P19/02 ,  A61P35/00

摘要： The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

公开(公告)号：WO2022140428A2

公开(公告)日：2022-06-30

申请号：PCT/US2021/064669

申请日：2021-12-21

申请人： GILEAD SCIENCES, INC.

发明人： BYUN, Daniel H. ,  CANALES, Eda Y. ,  DEBIEN, Laurent P. ,  JANSA, Petr ,  LEE, Rick A. ,  LOYER-DREW, Jennifer A. ,  PERREAULT, Stephane ,  PYUN, Hyung-Jung ,  SAITO, Roland D. ,  SANGI, Michael S. ,  SCHRIER, Adam J. ,  SHATSKIKH, Marina E. ,  TAYLOR, James G. ,  TREIBERG, Jennifer A. ,  VAN VELDHUIZEN, Joshua J. ,  XU, Lianhong

IPC分类号： C07D519/00 ,  A61P35/02 ,  A61K31/437

摘要： The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.