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公开(公告)号：WO2020092528A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058813
申请日：2019-10-30
发明人： BALAN, Gayatri , BARTLETT, Mark J. , CHANDRASEKHAR, Jayaraman , CODELLI, Julian A. , CONWAY, John H. , COSMAN, Jennifer L. , KALLA, Rao V. , KIM, Musong , LEE, Seung H. , LO, Jennifer R. , LOYER-DREW, Jennifer A. , MITCHELL, Scott A. , PERRY, Thao D. , PHILLIPS, Gary B. , SALVO, Patrick J. , VAN VELDHUIZEN, Joshua J. , YEUNG, Suet C. , ZABLOCKI, Jeff
IPC分类号： A61P31/18 , A61P31/20 , A61P35/00 , C07D471/04 , C07D519/00 , A61K31/444 , A61K31/4545
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：WO2022140390A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064618
申请日：2021-12-21
发明人： BYUN, Daniel H. , CAI, Zhenhong R. , CANALES, Eda Y. , DEBIEN, Laurent P. , HANSEN, Timothy R. , HUANG, Richard , JANSA, Petr , LEE, Rick A. , LOYER-DREW, Jennifer A. , MCFADDEN, Ryan , MITCHELL, Michael L. , PYUN, Hyung-Jung , SAITO, Roland D. , SANGI, Michael S. , SCHRIER, Adam J. , SHATSKIKH, Marina E. , TAYLOR, James G. , VAN VELDHUIZEN, Joshua J. , XU, Lianhong
IPC分类号： C07D401/14 , C07D471/04 , C07D519/00 , A61P35/02 , A61K31/437
摘要： The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：WO2021222353A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/029557
申请日：2021-04-28
发明人： CANALES, Eda Y. , CHANG, Weng K. , DEBIEN, Laurent P. , JANSA, Petr , LOYER-DREW, Jennifer A. , MARTINEZ, Luisruben P. , PERREAULT, Stephane , PHILLIPS, Gary B. , PYUN, Hyung-Jung , SAITO, Roland D. , SANGI, Michael S. , SCHRIER, Adam J. , SHATSKIKH, Marina E. , TAYLOR, James G. , TREIBERG, Jennifer A. , VAN VELDHUIZEN, Joshua J.
IPC分类号： C07D471/18 , C07D471/22 , C07D487/08 , C07D491/22 , C07D498/18 , C07D498/22 , C07D513/18 , A61P3/10 , A61P7/02 , A61P19/02 , A61P35/00
摘要： The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：WO2022140428A2
公开(公告)日：2022-06-30
申请号：PCT/US2021/064669
申请日：2021-12-21
发明人： BYUN, Daniel H. , CANALES, Eda Y. , DEBIEN, Laurent P. , JANSA, Petr , LEE, Rick A. , LOYER-DREW, Jennifer A. , PERREAULT, Stephane , PYUN, Hyung-Jung , SAITO, Roland D. , SANGI, Michael S. , SCHRIER, Adam J. , SHATSKIKH, Marina E. , TAYLOR, James G. , TREIBERG, Jennifer A. , VAN VELDHUIZEN, Joshua J. , XU, Lianhong
IPC分类号： C07D519/00 , A61P35/02 , A61K31/437
摘要： The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：WO2020092621A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058932
申请日：2019-10-30
发明人： BALAN, Gayatri , BARTLETT, Mark J. , CHANDRASEKHAR, Jayaraman , CODELLI, Julian A. , CONWAY, John H. , COSMAN, Jennifer L. , KALLA, Rao V. , KASUN, Zachary A. , KIM, Musong , LEE, Seung H. , LO, Jennifer R. , LOYER-DREW, Jennifer A. , MITCHELL, Scott A. , PERRY, Thao D. , PHILLIPS, Gary B. , SALVO, Patrick J. , SWAMINATHAN, Sundaramoorthi , VAN VELDHUIZEN, Joshua J. , YEUNG, Suet C. , ZABLOCKI, Jeff
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P35/00
摘要： The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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