公开(公告)号：WO2022271684A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/034321

申请日：2022-06-21

Applicant: GILEAD SCIENCES, INC.

Inventor： CODELLI, Julian, A. ,  GRAUPE, Michael ,  GUERRERO, Juan, A. ,  HOLMBO, Stephen, D. ,  KOBAYASHI, Tetsuya ,  MOAZAMI, Yasamin ,  PATEL, Leena, B. ,  WEAVER, Heath, A. ,  XU, Jie ,  YEUNG, Suet, C. ,  ZHU, QingMing

IPC: C07D487/04 ,  C07D519/00 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P35/04 ,  A61K31/519

Abstract: The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents formula (I).

公开(公告)号：WO2021096860A1

公开(公告)日：2021-05-20

申请号：PCT/US2020/059837

申请日：2020-11-10

Applicant: GILEAD SCIENCES, INC.

Inventor： CHU, Hang ,  GUERRERO, Juan A. ,  HURTLEY, Anna E. ,  JIANG, Lan ,  KATO, Darryl ,  KOBAYASHI, Tetsuya ,  LIN, David W. ,  MEDLEY, Jonathan William ,  NADUTHAMBI, Devan ,  TSUI, Vickie H. ,  VENKATARAMANI, Chandrasekar ,  WATKINS, William J. ,  YANG, Hong ,  ZHU, QingMing

IPC: A61P35/00 ,  C07D513/10 ,  C07D513/20 ,  C07D513/22 ,  C07D519/00 ,  A61K31/553

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.