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公开(公告)号：WO2020092375A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058573
申请日：2019-10-29
Applicant: GILEAD SCIENCES, INC.
Inventor： BLOMGREN, Peter A. , CAMPBELL, Taryn , CHANDRASEKHAR, Jayaraman , CLARK, Christopher T. , CODELLI, Julian A. , CURRIE, Kevin S. , KROPF, Jeffrey E. , MOAZAMI, Yasamin , NAVA, Nicole , PATEL, Leena , PERREAULT, Stephane , PERRY, Jason K. , SEDILLO, Kassandra F. , SEEGER, Natalie , STEVENS, Kirk L. , TREIBERG, Jennifer Anne , YEUNG, Suet C. , ZHAO, Zhongdong
IPC: C07D215/14 , C07D215/18 , C07D215/54 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D475/02 , C07D491/06 , A61K31/47 , A61P29/00
Abstract: The present disclosure provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
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公开(公告)号：WO2023039464A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/076099
申请日：2022-09-08
Applicant: GILEAD SCIENCES, INC.
Inventor： AMMANN, Stephen , CANALES, Eda Y. , CHANG, Weng K. , KINFE, Henok H. , SCHROEDER, Scott D. , LAZERWITH, Scott E. , MITCHELL, Michael L. , MOAZAMI, Yasamin , SHORE, Daniel G.
IPC: A61P29/00 , C07D519/00 , A61K31/4745
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.
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公开(公告)号：WO2022271684A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034321
申请日：2022-06-21
Applicant: GILEAD SCIENCES, INC.
Inventor： CODELLI, Julian, A. , GRAUPE, Michael , GUERRERO, Juan, A. , HOLMBO, Stephen, D. , KOBAYASHI, Tetsuya , MOAZAMI, Yasamin , PATEL, Leena, B. , WEAVER, Heath, A. , XU, Jie , YEUNG, Suet, C. , ZHU, QingMing
IPC: C07D487/04 , C07D519/00 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , A61K31/519
Abstract: The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents formula (I).
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公开(公告)号：WO2020092401A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058610
申请日：2019-10-29
Applicant: GILEAD SCIENCES, INC.
Inventor： BLOMGREN, Peter A. , CAMPBELL, Taryn , CHANDRASEKHAR, Jayaraman , CLARK, Christopher T. , CODELLI, Julian A. , CURRIE, Kevin S. , KROPF, Jeffrey E. , MOAZAMI, Yasamin , NAVA, Nicole , PATEL, Leena , PERREAULT, Stephane , PERRY, Jason K. , SEDILLO, Kassandra F. , SEEGER, Natalie , STEVENS, Kirk L. , TREIBERG, Jennifer Anne , YEUNG, Suet C. , ZHAO, Zhongdong
IPC: A61P29/00 , C07C233/73 , C07D213/61 , C07D215/14 , C07D239/46 , C07D249/06 , C07D311/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , A61K31/40
Abstract: The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
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Patent Agency Ranking
公开(公告)号：WO2020092394A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058599
申请日：2019-10-29
Applicant: GILEAD SCIENCES, INC.
Inventor： BLOMGREN, Peter A. , CAMPBELL, Taryn , CHANDRASEKHAR, Jayaraman , CLARK, Christopher T. , CODELLI, Julian A. , CURRIE, Kevin S. , KROPF, Jeffrey E. , MOAZAMI, Yasamin , NAVA, Nicole , PATEL, Leena , PERREAULT, Stephane , PERRY, Jason K. , SEDILLO, Kassandra F. , SEEGER, Natalie , STEVENS, Kirk L. , TREIBERG, Jennifer Anne , YEUNG, Suet C. , ZHAO, Zhongdong
IPC: C07D471/04 , C07D519/00 , A61K31/437 , A61P29/00
Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
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公开(公告)号：WO2023076983A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/078759
申请日：2022-10-27
Applicant: GILEAD SCIENCES, INC.
Inventor： BALAN, Gayatri , CHANDRASEKHAR, Jayaraman , CHANG, Jonah J. , CURRIE, Kevin S. , HOLMBO, Stephen D. , JACOBSEN, Jesse M. , KROPF, Jeffrey E. , LEE, Seung H. , MOAZAMI, Yasamin , PATEL, Leena B. , PAUL, Thomas J. , PERREAULT, Stephane , SALVO, Patrick J. , TREIBERG, Jennifer A. , WEAVER, Heath A.
IPC: C07D403/08 , C07D403/12 , C07D413/14 , C07D487/04 , A61P35/00 , A61K31/501 , A61K31/502 , A61K31/5025
Abstract: Provided herein is a compound of Formula (I) wherein the various substituents are described herein.
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公开(公告)号：WO2022271650A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034270
申请日：2022-06-21
Applicant: GILEAD SCIENCES, INC.
Inventor： CODELLI, Julian A. , GRAUPE, Michael , GUERRERO, Juan A. , JACOBSEN, Jesse M. , KOBAYASHI, Tetsuya , MEDLEY, Jonathan William , MOAZAMI, Yasamin , PATEL, Leena , XU, Jie , YEUNG, Suet C.
IPC: C07D471/14 , C07D487/04 , C07D519/00 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , A61K31/519
Abstract: The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：WO2021130638A1
公开(公告)日：2021-07-01
申请号：PCT/IB2020/062229
申请日：2020-12-18
Applicant: CARNA BIOSCIENCES, INC. , GILEAD SCIENCES, INC.
Inventor： SAWA, Masaaki , ARAI, Mai , NAKAI, Ryoko , MATSUMOTO, Hirokazu , PUGH, Catherine , HU, Eric , GUERRERO, Juan , JACOBSEN, Jesse , MEDLEY, Jonathan William , XU, Jie , LAD, Latesh , PATEL, Leena , GRAUPE, Michael , ZHU, Qingming , HOLMBO, Stephen , KOBAYASHI, Tetsuya , WATKINS, Will , MOAZAMI, Yasamin , YEUNG, Suet C. , CODELLI, Julian A. , WEAVER, Heath A.
IPC: A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P35/00 , A61P35/02 , A61P35/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/553 , A61K31/5415
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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公开(公告)号：WO2020092383A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058583
申请日：2019-10-29
Applicant: GILEAD SCIENCES, INC.
Inventor： BLOMGREN, Peter A. , CAMPBELL, Taryn , CHANDRASEKHAR, Jayaraman , CLARK, Christopher T. , CODELLI, Julian A. , CURRIE, Kevin S. , KROPF, Jeffrey E. , MOAZAMI, Yasamin , NAVA, Nicole , PATEL, Leena , PERREAULT, Stephane , PERRY, Jason K. , SEDILLO, Kassandra F. , SEEGER, Natalie , STEVENS, Kirk L. , TREIBERG, Jennifer Anne , YEUNG, Suet C. , ZHAO, Zhongdong
IPC: C07D405/04 , C07C233/87 , C07D215/12 , C07D215/227 , C07D265/36 , C07D307/87 , C07D311/04 , C07D311/58 , C07D311/94 , C07D319/18 , C07D321/10 , C07D401/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04 , A61K31/4709 , A61P29/00
Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
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