公开(公告)号：WO2003101505A1

公开(公告)日：2003-12-11

申请号：PCT/US2003/016865

申请日：2003-05-23

Applicant: GORE ENTERPRISE HOLDINGS, INC.

Inventor： COOK, Alonzo, D. ,  CUTRIGHT, Warren, J. ,  KRALL, Robert, S. ,  MONTGOMERY, William, D.

IPC: A61L31/06

CPC classification number: A61F2/82 ,  A61B6/12 ,  A61B8/0833 ,  A61B17/0057 ,  A61F2/01 ,  A61F2250/0097 ,  A61L31/048 ,  A61L31/10 ,  A61L31/146 ,  A61L31/18

Abstract: An implantable medical device including a porous membrane of expanded polytetrafluoroethylene that is treated with a hydrophilic polyvinyl alcohol to render said membrane transparent to technology for viewing inside a mammalian body. These technologies include ultrasound echocardiography and video imaging such as that used during laparoscopic procedures.

Abstract translation: 一种植入式医疗装置，其包括用亲水性聚乙烯醇处理的膨胀聚四氟乙烯多孔膜，以使所述膜对于哺乳动物体内观看的技术是透明的。 这些技术包括超声心动图和视频成像，如腹腔镜手术中使用的。

公开(公告)号：WO1997046267A1

公开(公告)日：1997-12-11

申请号：PCT/US1997009635

申请日：1997-06-02

Applicant: GORE ENTERPRISE HOLDINGS, INC.

Inventor： GORE ENTERPRISE HOLDINGS, INC. ,  COOK, Alonzo, D. ,  DRUMHELLER, Paul, D.

IPC: A61L27/00

CPC classification number: A61L31/148 ,  A61L27/34 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2300/64 ,  Y10S977/788 ,  Y10S977/931

Abstract: The present invention is directed to hydrophobic biodegradable polymeric materials having at least one surface thereof rendered more hydrophilic by attachment of at least one layer of a hydrophilic polymer thereto. The hydrophilic polymer layer is cross-linked together on the surface of the biodegradable material with a cross-linking agent or scheme that is biodegradable. Bioactive species are immobilized to chemically functional groups of the components of the first layer or to unreacted chemically functional groups of the cross-linking agent. Optionally, the bioactive species may be reversibly immobilized through chemically functional linkages that are degradable. The result is an implantable construction with immobilized bioactive species having structural components that are all subject to degradation in the body of a recipient.

Abstract translation: 本发明涉及疏水性可生物降解的聚合材料，其至少一个表面通过至少一层亲水性聚合物与其附着而变得更亲水。 亲水性聚合物层通过可生物降解的交联剂或方案在可生物降解材料的表面上交联在一起。 将生物活性物质固定化为第一层的组分的化学官能团或交联剂的未反应的化学官能团。 任选地，生物活性物质可以通过可降解的化学功能键可逆地固定。 结果是具有固定的生物活性物种的可植入结构，其具有在受体体内都会降解的结构成分。