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    LEAD WITH FIBROUS MATRIX COATING
    2.
    发明申请
    LEAD WITH FIBROUS MATRIX COATING 审中-公开
    引导与纤维基质涂料

    公开(公告)号：WO2007130900A2

    公开(公告)日：2007-11-15

    申请号：PCT/US2007067757

    申请日：2007-04-30

    Applicant: CARDIAC PACEMAKERS INC ,  POLKINGHORNE JEANNETTE C ,  JIANG XIANGCHUN ,  COOKE DANIEL J

    Inventor： POLKINGHORNE JEANNETTE C ,  JIANG XIANGCHUN ,  COOKE DANIEL J

    IPC: A61N1/05

    CPC classification number: A61N1/056 ,  A61N1/0568 ,  A61N2001/0585 ,  D01D5/0084 ,  Y10S977/904 ,  Y10S977/931

    Abstract: A lead includes a lead body extending from a lead proximal end portion to a lead distal end portion and having an intermediate portion therebetween, one or more tissue sensing/stimulation electrodes disposed along the lead body, one or more terminal connections disposed along the lead proximal end portion. The lead further includes one or more conductors contained within the lead body extending between the tissue sensing/stimulation electrodes and the terminal connections, and a fibrous matrix coating is disposed onto at least a portion of the lead body and/or sensing/stimulation electrodes.

    Abstract translation: 引线包括从引线近端部分延伸到引线远端部分并且在其间具有中间部分的引线体，沿着引线主体设置的一个或多个组织感测/刺激电极，沿着引线近端设置的一个或多个端子连接 端部。 引线还包括一个或多个导体，其包含在组织感测/刺激电极和端子连接之间延伸的引线体内，并且纤维基质涂层设置在引线体和/或感测/刺激电极的至少一部分上。

    METHODS AND COMPOSITIONS TO PREVENT FORMATION OF ADHESIONS IN BIOLOGICAL TISSUES
    8.
    发明申请
    METHODS AND COMPOSITIONS TO PREVENT FORMATION OF ADHESIONS IN BIOLOGICAL TISSUES 审中-公开
    用于防止生物组织中的粘附物形成的方法和装置

    公开(公告)号：WO99010022A2

    公开(公告)日：1999-03-04

    申请号：PCT/US1998/017754

    申请日：1998-08-27

    IPC: A61L31/00 ,  A61K31/77 ,  A61K31/78 ,  A61K31/79 ,  A61K31/80 ,  A61L27/34 ,  A61L29/00 ,  A61L31/06 ,  A61L31/10 ,  C08L101/02

    CPC classification number: A61L31/06 ,  A61K31/77 ,  A61K31/78 ,  A61K31/79 ,  A61K31/80 ,  A61L27/34 ,  A61L31/10 ,  Y10S525/937 ,  Y10S977/931 ,  C08L71/02 ,  C08L101/02

    Abstract: The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form following surgical procedures, are minimized. These materials contain a polymer of hydrophilic molecules such as polyethylene glycol (PEG) bound to a polymer that spontaneously adsorbs to biological tissue such as phenylboronic acid (PBA). The PEG-PBA co-polymer can be formed in a variety of geometries. The materials can also be used to coat prosthetics and other implants.

    Abstract translation: 本发明涉及在原位提供对身体组织表面的即时吸附并在这些组织之间提供立体屏障的材料，以便最小化由于外科手术而发生的组织粘连。 这些材料含有亲水性分子的聚合物，例如结合到聚合物上的聚乙二醇（PEG），其对生物组织进行自发吸附，例如苯基硼酸（PBA）。 该PEG-PBA共聚物可以制备成各种几何形状。 这些材料也可用于涂覆假体和其他植入物。

    CONTROLLED RELEASE BIODEGRADABLE MICRO- AND NANOSPHERES CONTAINING CYCLOSPORIN
    9.
    发明申请
    CONTROLLED RELEASE BIODEGRADABLE MICRO- AND NANOSPHERES CONTAINING CYCLOSPORIN 审中-公开
    受控释放的生物可降解的含有CYCLOSPORIN的微球和纳米磷

    公开(公告)号：WO1996031202A1

    公开(公告)日：1996-10-10

    申请号：PCT/IE1996000017

    申请日：1996-04-02

    Applicant: ELAN CORPORATION, PLC

    Inventor： ELAN CORPORATION, PLC ,  RAMTOOLA, Zebunnissa

    IPC: A61K31/13

    CPC classification number: A61K38/13 ,  A61K9/1647 ,  Y10S977/788 ,  Y10S977/795 ,  Y10S977/904 ,  Y10S977/915 ,  Y10S977/931

    Abstract: A controlled release pharmaceutical formulation which comprises cyclosporin entrapped in a biodegradable polymer to form microspheres or nanospheres such that the cyclosporin is substantially in an amorphous state and the biodegradable polymer comprises greater than 12.5 % w/w poly(lactide). The biodegradable polymer is suitably poly-D,L-lactide or a blend of poly-D,L-lactide and poly-D,L-lactide-co-glycolide. Additionally, an enteric coating can be applied to the microspheres or nanospheres or to the oral dosage form incorporating the microspheres or nanospheres to protect the formulation while it passes through the stomach. A particularly suitable formulation comprises 50 % w/w cyclosporin-loaded 80:20 blend of poly-D,L-lactide-co-glycolide to poly-D,L-lactide micro- and/or nanospheres. This formulation has the combined properties of nearly complete but relatively slow release of cyclosporin within 8 hours and is useful for targeting cyclosporin to the small intestine when administered orally.

    Abstract translation: 一种控释药物制剂，其包含环包埋在可生物降解聚合物中以形成微球体或纳米球体的环孢菌素，使得环孢菌素基本上处于非晶状态，生物可降解聚合物包含大于12.5％w / w的聚（丙交酯）。 生物可降解聚合物适宜为聚-D，L-丙交酯或聚-D，L-丙交酯和聚-D，L-丙交酯 - 共 - 乙交酯的共混物。 此外，肠溶衣可以应用于微球体或纳米球体或结合微球体或纳米球体的口服剂型，以在制剂通过胃部时保护制剂。 一种特别合适的制剂包含50％w / w的环孢菌素负载的聚-D，L-丙交酯 - 共 - 乙交酯的80:20共混物与聚-D，L-丙交酯微米和/或纳米球。 该制剂具有在8小时内几乎完全但相对缓慢释放环孢菌素的组合性质，并且用于口服给药时将环孢菌素靶向小肠。

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