公开(公告)号：WO2006086201A2

公开(公告)日：2006-08-17

申请号：PCT/US2006003599

申请日：2006-01-30

Applicant: HANUMAN LLC ,  CELL FACTOR TECHNOLOGIES INC ,  LEACH MICHAEL D

Inventor： LEACH MICHAEL D ,  DORIAN RANDEL

IPC: A61M1/36 ,  B04B5/00

CPC classification number: B01D63/02 ,  A61M1/0281 ,  A61M1/3482 ,  A61M1/3496 ,  A61M1/3633 ,  A61M1/3679 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2202/0427 ,  B01D2313/44 ,  B01D2313/58 ,  B01F11/0005 ,  B01F13/0052 ,  B04B5/0442 ,  B04B2005/0478

Abstract: The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.

Abstract translation: 本发明的PRP分离器集中器适用于创伤受害者的办公用途或紧急用途。 PRP分离器包括电动离心分离组件和集中器组件。 离心分离器组件包括离心鼓分离器，其包括红细胞捕获模块和具有连接到离心鼓分离器的驱动轴的马达。 浓缩器组件包括用于制备PRP浓缩物的去水模块。 离心鼓分离器具有红细胞捕集器。 除水模块可以是具有吸水珠的注射器装置，或者其可以是泵中空纤维筒组件。 中空纤维是具有孔的膜，其允许水流过纤维膜，同时排除可用于密封和粘附组织的凝血因子的流动和有助于愈合的生长因子，同时避免血小板活化和破坏PRP中存在的任何痕量红细胞 。

公开(公告)号：WO2008016574A2

公开(公告)日：2008-02-07

申请号：PCT/US2007017055

申请日：2007-07-31

Applicant: HANUMAN LLC ,  BIOMET BIOLOG INC ,  DORIAN RANDEL ,  LEACH MICHAEL D

Inventor： DORIAN RANDEL ,  LEACH MICHAEL D

IPC: B01D24/32 ,  B01D33/067 ,  B01D35/00

CPC classification number: A61M1/3693 ,  A61M1/3633 ,  A61M1/3696 ,  A61M2202/0427 ,  B04B5/0442 ,  B04B2005/0478

Abstract: A Platelet Rich Plasma separator assembly is disclosed. The assembly can include a cylindrical outer wall closed at the top by an upper plate and closed at the bottom. A bottom plate having an upper surface sloped down to a central opening. The top edge of the inner wall terminates at a distance from the upper plate to define an annular erythrocyte passageway therebetween. The inner wall has an outer surface and an inner surface that slopes radially inward from its top edge to its bottom at an angle of from 0.2 to 5 degrees with a central axis of the inner wall. A cylindrical depth filter is positioned between the inner surface of the outer wall and the outer surface of the inner wall in communication with the inner wall through the erythrocyte passageway.

Abstract translation: 公开了一种富血小板血浆分离器组件。 组件可以包括在顶部由上板封闭并在底部封闭的圆柱形外壁。 底板，其具有向下倾斜到中心开口的上表面。 内壁的顶边缘终止于距上板一定距离处，以在其间限定环形红细胞通道。 内壁具有外表面和内表面，内表面与内壁的中心轴线以从0.2到5度的角度从其顶部边缘到其底部向内径向倾斜。 圆柱形深度过滤器位于外壁的内表面和内壁的外表面之间，通过红细胞通道与内壁连通。