公开(公告)号：WO2016128983A1

公开(公告)日：2016-08-18

申请号：PCT/IL2016/050170

申请日：2016-02-11

Applicant: HEMODYNAMX-TECHNOLOGIES LTD.

Inventor： KARAVANY, Sagy ,  FELD, Tanhum ,  NISHRI, Boaz

IPC: A61F2/06

CPC classification number: A61F2/06 ,  A61F2002/068 ,  A61F2230/0067

Abstract: Apparatus and methods are described for regulating blood flow in an ascending aorta of a subject including inserting a device (20) into the ascending aorta. When in a deployed state, the device defines an inner surface (24) that defines a conduit (26) through the device, at least a portion (25) of the inner surface diverging, such that a cross-sectional area of the conduit at the downstream end (34) of the diverging portion is greater than a cross-sectional area of the conduit at the upstream end (30) of the diverging portion. The device is deployed within a longitudinal portion of the ascending aorta, such that blood flow through the portion of the ascending aorta, via any flow path other than through the conduit, is less than 20 percent of total blood flow through the portion of the ascending aorta. Other applications are also described.

Abstract translation: 描述了用于调节受试者的升主动脉中的血流的装置和方法，包括将装置（20）插入升主动脉。 当处于展开状态时，该装置限定了内表面（24），该内表面限定通过装置的导管（26），内表面的至少一部分（25）发散，使得导管的横截面积 发散部分的下游端（34）大于在发散部分的上游端（30）处的导管的横截面面积。 该装置部署在升主动脉的纵向部分内，使得通过除通过导管之外的任何流动路径通过上升主动脉的部分的血液小于通过上升部分的总血流量的20％ 主动脉。 还描述了其它应用。

公开(公告)号：WO2020234787A1

公开(公告)日：2020-11-26

申请号：PCT/IB2020/054761

申请日：2020-05-20

Applicant: HEMODYNAMX-TECHNOLOGIES LTD

Inventor： KARAVANY, Sagy ,  YACOBY, Menashe ,  FELD, Tanhum

IPC: A61F2/07 ,  A61F2/915 ,  A61F2/06 ,  A61F2/848

Abstract: Apparatus and methods are described including an aortic pressure-loss-reduction device (20) configured to be implanted inside an ascending aorta of a subject. The aortic pressure-loss-reduction device includes a frame (52) that defines an upstream anchor portion (56UF), an intermediate portion (23F) configured to define a conduit (26) therethrough, and a downstream anchor portion (56DF). Angled struts (150) are disposed between a downstream end of the upstream anchor portion (56UF) and an upstream end of the intermediate portion (23F). The angled struts (150) are configured such that, in response to a diameter of the upstream anchor portion (56UF) changing by an absolute amount, an absolute change in a diameter of the upstream end of the intermediate portion (23F) is less than the absolute amount by which the diameter of the upstream anchor portion (56 UF) changes. Other applications are also described.

公开(公告)号：WO2018220589A1

公开(公告)日：2018-12-06

申请号：PCT/IB2018/053925

申请日：2018-05-31

Applicant: HEMODYNAMX TECHNOLOGIES, LTD.

Inventor： KARAVANY, Sagy ,  TEICHMAN, Eyal

IPC: A61F2/06

Abstract: The devices and methods described herein include an implantable body lumen fluid flow modulator including an upstream flow accelerator separated by a gap from a downstream flow decelerator. The gap is a pathway to entrain additional fluid from a branch lumen(s) into the fluid stream flowing from the upstream flow accelerator to the downstream flow decelerator.

公开(公告)号：WO2019097424A3

公开(公告)日：2019-05-23

申请号：PCT/IB2018/058961

申请日：2018-11-14

Applicant: HEMODYNAMX-TECHNOLOGIES LTD

Inventor： KARAVANY, Sagy ,  YACOBY, Menashe ,  FELD, Tanhum

IPC: A61F2/07 ,  A61F2/06 ,  A61F2/24 ,  A61F2/82 ,  A61F2/90 ,  A61F2/95 ,  A61F2/962

Abstract: Apparatus and methods are described including implanting an aortic pressure-loss- reduction device (20) in a subject's ascending aorta. While the device is inside a catheter (42), a distal end of the catheter is placed within the ascending aorta. A proximal covering sheath (44) of the catheter is retracted such as to uncover at least a portion of a downstream anchor (31), such that the uncovered portion of the downstream anchor includes a portion of the frame that does not have material coupled thereto. Subsequently, a distal covering sheath (45) of the catheter is advanced, such as to cause an upstream anchor (33) to anchor an upstream end device (20) to the subject's ascending aorta, by the upstream anchor radially expanding against an inner wall of the ascending aorta. Other applications are also described.

公开(公告)号：WO2019097424A2

公开(公告)日：2019-05-23

申请号：PCT/IB2018/058961

申请日：2018-11-14

Applicant: HEMODYNAMX-TECHNOLOGIES LTD

Inventor： KARAVANY, Sagy ,  YACOBY, Menashe ,  FELD, Tanhum

IPC: A61F2/06

CPC classification number: A61F2/966 ,  A61F2/06 ,  A61F2/07 ,  A61F2/915 ,  A61F2002/068 ,  A61F2002/8486 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91575 ,  A61F2230/001 ,  A61F2230/0067

Abstract: Apparatus and methods are described including implanting an aortic pressure-loss- reduction device (20) in a subject's ascending aorta. While the device is inside a catheter (42), a distal end of the catheter is placed within the ascending aorta. A proximal covering sheath (44) of the catheter is retracted such as to uncover at least a portion of a downstream anchor (31), such that the uncovered portion of the downstream anchor includes a portion of the frame that does not have material coupled thereto. Subsequently, a distal covering sheath (45) of the catheter is advanced, such as to cause an upstream anchor (33) to anchor an upstream end device (20) to the subject's ascending aorta, by the upstream anchor radially expanding against an inner wall of the ascending aorta. Other applications are also described.

公开(公告)号：WO2018029688A1

公开(公告)日：2018-02-15

申请号：PCT/IL2017/050884

申请日：2017-08-10

Applicant: HEMODYNAMX-TECHNOLOGIES LTD

Inventor： KARAVANY, Sagy ,  FELD, Tanhum ,  NISHRI, Boaz ,  YACOBY, Menashe

IPC: A61F2/06 ,  A61F2/24

CPC classification number: A61F2/06 ,  A61F2/966 ,  A61F2002/068 ,  A61F2002/91525 ,  A61F2230/0093 ,  A61F2250/0039

Abstract: Apparatus and methods are described including inserting an implantable device (20) into a blood vessel of a subject while the implantable device is disposed inside a delivery device and is constrained in a constrained configuration by the delivery device. The implantable device is released from the delivery device into the blood vessel, thereby causing the implantable device to assume a non-constrained configuration by an upstream end of the implantable device radially expanding (120), a central portion (122) of the implantable device radially expanding such that along the central portion of the implantable device the inner surface (24) of the implantable device defines a diverging portion (25) of a conduit (26), and the implantable device forming a folded portion (128) between the upstream end of the implantable device and the central portion of the implantable device. Other applications are also described.

Abstract translation: 描述了包括将可植入装置（20）插入到受试者的血管内的装置和方法，同时将可植入装置设置在递送装置内部并且由递送装置将其约束为受约束的构型。 可植入装置从输送装置释放到血管中，由此通过可植入装置的上游端径向扩张（120）而使可植入装置呈现非限制配置，可植入装置的中心部分（122） 径向扩张，使得沿着可植入装置的中心部分，可植入装置的内表面（24）限定导管（26）的分叉部分（25），并且可植入装置在上游 可植入装置的端部和可植入装置的中央部分。 还介绍了其他应用程序。