公开(公告)号：WO2016156841A1

公开(公告)日：2016-10-06

申请号：PCT/GB2016/050894

申请日：2016-03-30

Applicant: HOVIONE SCIENTIA LIMITED ,  TURNER, Craig

Inventor： FONSECA, Tiago ,  DUARTE, Iris ,  TEMTEM, Márcio ,  VICENTE, João

IPC: A61K9/14 ,  A61K31/55 ,  A61K31/56

CPC classification number: B01D9/0054 ,  A61K9/145 ,  A61K31/55 ,  A61K31/56 ,  B01D9/0072 ,  B01D63/005 ,  B01D63/088 ,  B05B1/02 ,  B05B12/1445 ,  F26B3/12 ,  F26B17/101

Abstract: The present invention discloses a method to continuously manufacture micro- and/or nanoparticles of single component particles or multi-component particles such as particulate amorphous solid dispersions or particulate co-crystals. The continuous method comprises the steps of 1. preparing a first solution comprising at least one component and at least one solvent and a second solution comprising at least one anti-solvent of the at least one component comprised in the first solution, 2. mixing said first solution and said second solution by means of microfluidization to produce a suspension by precipitation or co-precipitation, 3. feeding said suspension to a filtration system to obtain a concentrate stream, 4. feeding said concentrate stream to a spray dryer, 5. atomizing said concentrate stream using at least one atomization nozzle, 6. drying said atomized concentrate stream to obtain particles, and 7. collecting said particles. Single component particles or multi-component particles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compositions are also disclosed.

Abstract translation: 本发明公开了一种连续制造单组分颗粒或多组分颗粒如颗粒无定形固体分散体或颗粒状共晶的微米和/或纳米颗粒的方法。 连续方法包括以下步骤：1.制备包含至少一种组分和至少一种溶剂的第一溶液和包含至少一种包含在第一溶液中的至少一种组分的抗溶剂的第二溶液; 2.将所述 第一溶液和所述第二溶液通过微流化反应以通过沉淀或共沉淀产生悬浮液，3.将所述悬浮液加入过滤系统中以获得浓缩物流，4.将所述浓缩物流送入喷雾干燥器，5.雾化 所述浓缩物流使用至少一个雾化喷嘴，6.干燥所述雾化浓缩物流以获得颗粒，和7.收集所述颗粒。 还公开了单组分颗粒或多组分颗粒，颗粒无定形固体分散体，颗粒共晶和药物组合物。

公开(公告)号：WO2016016665A1

公开(公告)日：2016-02-04

申请号：PCT/GB2015/052233

申请日：2015-07-31

Applicant: HOVIONE INTERNATIONAL LTD ,  TURNER, Craig

Inventor： TEMTEM, Marcio ,  PEREIRA, Ruben ,  VICENTE, João ,  GASPER, Filipe ,  DUARTE, Iris

IPC: A61K9/14 ,  A61K9/16

CPC classification number: A61K9/146 ,  A61K9/10 ,  A61K9/1635 ,  A61K9/1694 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/55

Abstract: The present invention discloses a method for producing amorphous solid dispersions in a nanoparticulate form, through solvent controlled co-precipitation, using microfluidization/microreaction technology to promote high energy mixing/interaction at a micro and/or molecular level between the streams involved in the process. Feed streams, solvent and anti-solvent, are fed to an intensifier pump at individually controlled rates and forced to interact to micro-and/or nano-scale within a microreactor. The present invention also discloses amorphous solid dispersions obtained by the method of the invention as well as pharmaceutical compositions containing the same.

Abstract translation: 本发明公开了一种通过溶剂控制共沉淀法制备纳米颗粒形式的无定形固体分散体的方法，使用微流化/微反应技术在微流程和/或分子水平上促进在该过程中涉及的流之间的高能量混合/相互作用 。 进料流，溶剂和反溶剂以单独控制的速率进料到增压泵，并在微反应器内强制与微量和/或纳米级相互作用。 本发明还公开了通过本发明的方法获得的无定形固体分散体以及含有它们的药物组合物。