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    NANOFLUIDIC SORTING SYSTEM FOR GENE SYNTHESIS AND PCR REACTION PRODUCTS
    2.
    发明申请
    NANOFLUIDIC SORTING SYSTEM FOR GENE SYNTHESIS AND PCR REACTION PRODUCTS 审中-公开
    用于基因合成和PCR反应产物的纳米级分选系统

    公开(公告)号：WO2014105246A3

    公开(公告)日：2014-08-07

    申请号：PCT/US2013063404

    申请日：2013-10-04

    Applicant: MASSACHUSETTS INST TECHNOLOGY

    Inventor： AGUILAR CARLOS ANDRES ,  JAIN TARUN KUMAR ,  KARNIK ROHIT N ,  CARR PETER A

    IPC: B82Y35/00

    CPC classification number: B01D69/02 ,  B01D61/44 ,  B01D63/005 ,  B01D67/0088 ,  B01D67/009 ,  B01D69/125 ,  B01D71/02 ,  B01D2323/30 ,  B01D2325/028 ,  B01D2325/26 ,  B01L3/502761 ,  B32B37/26 ,  G01N15/1056 ,  G01N15/12 ,  G01N27/44756 ,  G01N33/48721 ,  G01N2015/0038 ,  G01N2015/1081

    Abstract: Devices and methods integrate nanopore and microfluidic technologies for recording molecular characteristics of individual molecules such as, for example, biomolecules. Devices comprise a first substrate comprising a microchannel, a second substrate comprising a microchannel, the second substrate positioned below the first substrate, and a membrane having a thickness of about 0.3 nm to about 1 nm and comprising at least one nanopore, the membrane positioned between the first substrate and the second substrate, wherein a single nanopore of the membrane is constructed and arranged for electrical and fluid communication between the microchannel of the first substrate and the microchannel of the second substrate. To mitigate the effect of errors that occur during de novo DNA synthesis, longer DNA molecules are typically synthesized from shorter oligonucleotides by polymerase construction and amplification (PCA), or by other methods.

    Abstract translation: 装置和方法集成了纳米孔和微流体技术，用于记录各个分子的分子特征，例如生物分子。 装置包括包括微通道的第一基板，包括微通道的第二基板，位于第一基板下方的第二基板和厚度为约0.3nm至约1nm的膜，并且包括至少一个纳米孔，所述膜位于 所述第一基板和所述第二基板，其中所述膜的单个纳米孔被构造和布置成用于在所述第一基板的微通道和所述第二基板的微通道之间的电和流体连通。 为了减轻从头DNA合成期间发生的错误的影响，通常通过聚合酶构建和扩增（PCA）或其他方法从较短的寡核苷酸合成更长的DNA分子。

    EXTRACTION AND CONCENTRATION DEVICE
    3.
    发明申请
    EXTRACTION AND CONCENTRATION DEVICE 审中-公开
    萃取和浓缩装置

    公开(公告)号：WO2016049698A1

    公开(公告)日：2016-04-07

    申请号：PCT/AU2015/050589

    申请日：2015-09-30

    Applicant: UNIVERSITY OF TASMANIA

    Inventor： SHALLAN, Aliaa Ibrahim Gaber ,  GUIJT, Rosanne Marieke ,  BREADMORE, Michael Charles

    IPC: G01N1/40 ,  B01D17/00 ,  B01D17/06 ,  B01D57/02 ,  B01D61/42 ,  B07C5/04 ,  B07C5/36

    CPC classification number: G01N27/44791 ,  B01D17/06 ,  B01D61/18 ,  B01D63/005 ,  B01D71/50 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2300/0864 ,  B01L2400/0421 ,  G01N1/40 ,  G01N1/4005 ,  G01N15/0266 ,  G01N15/0272 ,  G01N27/44704 ,  G01N27/44743 ,  G01N33/48721 ,  G01N2001/4038

    Abstract: A device for extracting and concentrating a target analyte including a sample channel that receives the sample, a separation channel, a waste channel, a first junction between the sample channel and the separation channel, and, a second junction between the separation channel and the waste channel. The first junction selectively transports a first group of analytes, including target analytes, from the sample channel to the separation channel in accordance with a size of a first free transport region of the first junction. The second junction selectively transports a second group of analytes from the separation channel to the waste channel in accordance with a size of a second free transport region of the second junction, the second group being a subset of the first group, so as to concentrate a number of the target analytes in the separation channel.

    Abstract translation: 一种用于提取和浓缩目标分析物的装置，包括接收样品的样品通道，分离通道，废液通道，样品通道和分离通道之间的第一连接点，以及分离通道和废物之间的第二连接点 渠道。 第一接头根据第一结的第一自由传输区的大小，将第一组分析物（包括目标分析物）从样品通道选择性地传输到分离通道。 第二接头根据第二接头的第二自由传输区域的尺寸，将第二组分析物从分离通道选择性地输送到废物通道，第二组是第一组的子集，以便集中 分离通道中目标分析物的数量。

    NANO WIRE MICROPOROUS STRUCTURE
    5.
    发明申请
    NANO WIRE MICROPOROUS STRUCTURE 审中-公开
    纳米线微孔结构

    公开(公告)号：WO2017069770A1

    公开(公告)日：2017-04-27

    申请号：PCT/US2015/057072

    申请日：2015-10-23

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： BARCELO, Steven ,  GE, Ning ,  ROGACS, Anita

    IPC: B01D39/00 ,  B01D69/00 ,  B01D71/00

    CPC classification number: B01D63/088 ,  B01D39/1692 ,  B01D61/38 ,  B01D63/005 ,  B01D67/0004 ,  B01D67/0034 ,  B01D67/0037 ,  B01D67/0069 ,  B01D67/0072 ,  B01D69/04 ,  B01D2325/028

    Abstract: A microporous structure includes an array of nano wires and a coating about the nano wires of the array. The coating defines pores between the nano wires. And a sample preparation device comprises a donor phase microfluidic channel, an acceptor phase microfluidic channel and a supported liquid membrane between the donor phase microfluidic channel and the acceptor phase microfluidic channel, wherein the supported liquid membrane has a microporous structure comprising an array of nano wires, a coating defining pores between the nano wires and an organic phase supported within the pores.

    Abstract translation: 微孔结构包括纳米线阵列和围绕阵列的纳米线的涂层。 涂层限定纳米线之间的孔隙。 并且样品制备装置包括供体相微流体通道，受体相微流体通道以及供体相微流体通道和受体相微流体通道之间的支持液体膜，其中支持液体膜具有包含纳米线阵列的微孔结构 ，限定纳米线之间的孔的涂层和支撑在孔内的有机相。

    MICRO FLOW FILTRATION SYSTEM AND INTEGRATED MICROFLUIDIC ELEMENT
    6.
    发明申请
    MICRO FLOW FILTRATION SYSTEM AND INTEGRATED MICROFLUIDIC ELEMENT 审中-公开
    微流过滤系统和集成微流体元件

    公开(公告)号：WO2013144089A1

    公开(公告)日：2013-10-03

    申请号：PCT/EP2013/056294

    申请日：2013-03-25

    Applicant: ROCHE DIAGNOSTICS GMBH ,  F. HOFFMANN-LA ROCHE AG ,  ORANTH, Norbert ,  LOSLEBEN, Nadine ,  LUTZ, Sascha ,  GROSSMANN, Adelbert

    Inventor： ORANTH, Norbert ,  LOSLEBEN, Nadine ,  LUTZ, Sascha ,  GROSSMANN, Adelbert

    IPC: G01N1/40 ,  B01D63/00 ,  B01D63/08 ,  B01L3/00

    CPC classification number: B01D63/005 ,  B01D61/147 ,  B01D61/22 ,  B01D63/087 ,  B01D63/088 ,  B01D2311/14 ,  B01D2311/246 ,  B01D2311/25 ,  B01D2313/90 ,  B01D2315/10 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/146 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/088 ,  B01L2400/0478 ,  B01L2400/0487 ,  G01N2001/4088

    Abstract: A micro fluid filtration system (100) preferably for increasing the concentration of components contained in a fluid sample has a fluid circuitry (1). The fluid circuitry (1) comprises the following elements: A tangential flow filtration element (7) capable for separating the fluid sample into a retentate stream and a permeate stream upon passage of the fluid, an element for pumping (3) for creating and driving a fluid flow through the fluid circuitry (1) and at least one element for obtaining information about the properties of the fluid sample within the circuitry. The circuitry further comprises a plurality of conduits (24) connecting the elements of the fluid circuitry (1) through which a fluid stream of the fluid sample is conducted. The circuitry (1) has a minimal working volume of at most 5 ml, which is the minimal fluid volume retained in the elements and the conduits (24) of the circuitry (1) such that the fluid can be recirculated in the circuitry (1) without pumping air through the circuitry (1). An integrated microfluidic element (20) of the circuitry (1) contains the functionality of at least two elements of the group of elements of the circuitry (1).

    Abstract translation: 微流体过滤系统（100）优选地用于增加包含在流体样品中的组分的浓度具有流体回路（1）。 流体回路（1）包括以下元件：切向流过滤元件（7），其能够在流体通过时将流体样品分离成滞留物流和渗透物流，用于泵送的元件（3）用于产生和驱动 通过流体电路（1）的流体流和至少一个元件，用于获得关于电路内的流体样品的属性的信息。 电路还包括连接流体回路（1）的元件的多个导管（24），流体样品的流体流通过该导管传导。 电路（1）具有至多5ml的最小工作体积，其是保留在电路（1）的元件和导管（24）中的最小流体体积，使得流体可以在电路（1）中再循环 ）而不通过电路（1）抽空。 电路（1）的集成微流体元件（20）包含电路（1）的元件组中的至少两个元件的功能。

    CONTINUOUS PRODUCTION OF PARTICLES
    7.
    发明申请
    CONTINUOUS PRODUCTION OF PARTICLES 审中-公开
    连续生产颗粒

    公开(公告)号：WO2016156841A1

    公开(公告)日：2016-10-06

    申请号：PCT/GB2016/050894

    申请日：2016-03-30

    Applicant: HOVIONE SCIENTIA LIMITED ,  TURNER, Craig

    Inventor： FONSECA, Tiago ,  DUARTE, Iris ,  TEMTEM, Márcio ,  VICENTE, João

    IPC: A61K9/14 ,  A61K31/55 ,  A61K31/56

    CPC classification number: B01D9/0054 ,  A61K9/145 ,  A61K31/55 ,  A61K31/56 ,  B01D9/0072 ,  B01D63/005 ,  B01D63/088 ,  B05B1/02 ,  B05B12/1445 ,  F26B3/12 ,  F26B17/101

    Abstract: The present invention discloses a method to continuously manufacture micro- and/or nanoparticles of single component particles or multi-component particles such as particulate amorphous solid dispersions or particulate co-crystals. The continuous method comprises the steps of 1. preparing a first solution comprising at least one component and at least one solvent and a second solution comprising at least one anti-solvent of the at least one component comprised in the first solution, 2. mixing said first solution and said second solution by means of microfluidization to produce a suspension by precipitation or co-precipitation, 3. feeding said suspension to a filtration system to obtain a concentrate stream, 4. feeding said concentrate stream to a spray dryer, 5. atomizing said concentrate stream using at least one atomization nozzle, 6. drying said atomized concentrate stream to obtain particles, and 7. collecting said particles. Single component particles or multi-component particles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compositions are also disclosed.

    Abstract translation: 本发明公开了一种连续制造单组分颗粒或多组分颗粒如颗粒无定形固体分散体或颗粒状共晶的微米和/或纳米颗粒的方法。 连续方法包括以下步骤：1.制备包含至少一种组分和至少一种溶剂的第一溶液和包含至少一种包含在第一溶液中的至少一种组分的抗溶剂的第二溶液; 2.将所述 第一溶液和所述第二溶液通过微流化反应以通过沉淀或共沉淀产生悬浮液，3.将所述悬浮液加入过滤系统中以获得浓缩物流，4.将所述浓缩物流送入喷雾干燥器，5.雾化 所述浓缩物流使用至少一个雾化喷嘴，6.干燥所述雾化浓缩物流以获得颗粒，和7.收集所述颗粒。 还公开了单组分颗粒或多组分颗粒，颗粒无定形固体分散体，颗粒共晶和药物组合物。

    A MICRO-DIALYSIS PROBE AND A METHOD OF MAKING THE PROBE
    10.
    发明申请
    A MICRO-DIALYSIS PROBE AND A METHOD OF MAKING THE PROBE 审中-公开
    微型探索探针和制作探针的方法

    公开(公告)号：WO2009095020A1

    公开(公告)日：2009-08-06

    申请号：PCT/DK2009/000023

    申请日：2009-01-30

    Applicant: DIRAMO A/S ,  TRÖSKEN, Volker ,  STENSTRØM, Theiss ,  DIRAC, Holger

    Inventor： TRÖSKEN, Volker ,  STENSTRØM, Theiss ,  DIRAC, Holger

    IPC: A61B5/00 ,  A61M25/00 ,  B01D61/28

    CPC classification number: A61M25/0026 ,  A61B5/145 ,  A61B5/14528 ,  B01D61/28 ,  B01D63/005 ,  B01D63/06 ,  B01D63/061

    Abstract: A method of making a micro-dialysis probe (6) by providing a first flow channel (4), a second flow channel (5) and a separating wall (3) arranged in such a manner that it separates the first flow channel (4) and the second flow channel (5). The method further comprises providing at least one opening (7) in an outer wall (2) of the first (4) or second (5) flow channel, and arranging a semi-permeable membrane tube (8) therein. Finally, the method comprises removing material from the separating wall (3), thereby providing a communication opening (9) providing fluid communication between the first flow channel (4) and the second flow channel (5). The method is very easy to perform, and it is suitable for mass production. The invention further relates to a micro-dialysis probe (6).

    Abstract translation: 一种通过提供第一流动通道（4），第二流动通道（5）和分隔壁（3）来制造微量透析探针（6）的方法，其以这样一种方式排列，即，将第一流动通道（4） ）和第二流动通道（5）。 该方法还包括在第一（4）或第二（5）流动通道的外壁（2）中提供至少一个开口（7），并在其中设置半透膜隔离管（8）。 最后，该方法包括从分离壁（3）中移除材料，从而提供在第一流动通道（4）和第二流动通道（5）之间提供流体连通的连通开口（9）。 该方法非常容易实现，适合批量生产。 本发明还涉及微透析探针（6）。

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