公开(公告)号：WO2017079519A1

公开(公告)日：2017-05-11

申请号：PCT/US2016/060468

申请日：2016-11-04

Applicant: INCYTE CORPORATION

Inventor： SHVARTSBART, Artem ,  SHEPARD, Stacey ,  COMBS, Andrew P. ,  SHAO, Lixin ,  FALAHATPISHEH, Nikoo ,  ZOU, Ge ,  BUESKING, Andrew W. ,  SPARKS, Richard B. ,  YUE, Eddy W. ,  JALLURI, Ravi

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/519 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K -γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Abstract translation: 本申请涉及作为PI3Kα-γ抑制剂的式（I）化合物或其药学上可接受的盐或立体异构体，其可用于治疗疾病 作为自身免疫性疾病，癌症，心血管疾病和神经退行性疾病。