公开(公告)号：WO2019226213A2

公开(公告)日：2019-11-28

申请号：PCT/US2019/021186

申请日：2019-03-07

Applicant: INCYTE CORPORATION

Inventor： SHEPARD, Stacey ,  COMBS, Andrew P. ,  FALAHATPISHEH, Nikoo ,  SHAO, Lixin

Abstract: This application relates to compounds of Formula (I): (I) or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：WO2019226213A3

公开(公告)日：2019-11-28

申请号：PCT/US2019/021186

申请日：2019-03-07

Applicant: INCYTE CORPORATION

Inventor： SHEPARD, Stacey ,  COMBS, Andrew P. ,  FALAHATPISHEH, Nikoo ,  SHAO, Lixin

IPC: C07D241/20 ,  C07D241/28 ,  C07D403/04 ,  C07D403/08 ,  C07D403/14 ,  C07D405/12 ,  C07D413/14 ,  C07D413/04 ,  C07D417/04 ,  A61P35/00 ,  A61K31/497

Abstract: This application relates to compounds of Formula (I): (I) or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：WO2017223414A1

公开(公告)日：2017-12-28

申请号：PCT/US2017/038955

申请日：2017-06-23

Applicant: INCYTE CORPORATION

Inventor： BUESKING, Andrew W. ,  SPARKS, Richard B. ,  COMBS, Andrew P. ,  DOUTY, Brent ,  FALAHATPISHEH, Nikoo ,  SHAO, Lixin ,  SHEPARD, Stacey ,  YUE, Eddy W.

IPC: C07D487/04 ,  A61K31/4985 ,  A61P35/00

Abstract: This application relates to compounds of Formula (I) or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Abstract translation: 本申请涉及作为PI3K-γ抑制剂的式（I）化合物或其药学上可接受的盐或立体异构体，其可用于治疗诸如自身免疫性疾病，癌症，心血管疾病 ，和神经退行性疾病。

公开(公告)号：WO2020102198A1

公开(公告)日：2020-05-22

申请号：PCT/US2019/060923

申请日：2019-11-12

Applicant: INCYTE CORPORATION

Inventor： FALAHATPISHEH, Nikoo ,  SHEPARD, Stacey ,  AI, Yanran ,  COMBS, Andrew P. ,  SHAO, Lixin ,  SHVARTSBART, Artem

IPC: C07D487/04 ,  A61P9/00 ,  A61P25/28 ,  A61P35/00 ,  A61P37/00 ,  A61K31/4985

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：WO2020010003A1

公开(公告)日：2020-01-09

申请号：PCT/US2019/040147

申请日：2019-07-01

Applicant: INCYTE CORPORATION

Inventor： DOUTY, Brent ,  AI, Yanran ,  BURNS, David M. ,  COMBS, Andrew P. ,  FALAHATPISHEH, Nikoo ,  LEVY, Daniel ,  POLAM, Padmaja ,  SHAO, Lixin ,  SHEPARD, Stacey ,  SHVARTSBART, Artem ,  YUE, Eddy W.

IPC: A61P9/00 ,  A61P25/28 ,  A61P35/00 ,  A61P37/00 ,  C07D241/20 ,  C07D241/28 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D493/08 ,  C07F5/02 ,  A61K31/497

Abstract: This application relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：WO2017079519A1

公开(公告)日：2017-05-11

申请号：PCT/US2016/060468

申请日：2016-11-04

Applicant: INCYTE CORPORATION

Inventor： SHVARTSBART, Artem ,  SHEPARD, Stacey ,  COMBS, Andrew P. ,  SHAO, Lixin ,  FALAHATPISHEH, Nikoo ,  ZOU, Ge ,  BUESKING, Andrew W. ,  SPARKS, Richard B. ,  YUE, Eddy W. ,  JALLURI, Ravi

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/519 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K -γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Abstract translation: 本申请涉及作为PI3Kα-γ抑制剂的式（I）化合物或其药学上可接受的盐或立体异构体，其可用于治疗疾病 作为自身免疫性疾病，癌症，心血管疾病和神经退行性疾病。

公开(公告)号：WO2022182839A1

公开(公告)日：2022-09-01

申请号：PCT/US2022/017654

申请日：2022-02-24

Applicant: INCYTE CORPORATION

Inventor： SHEPARD, Stacey ,  COLE, Charles ,  FALAHATPISHEH, Nikoo ,  LIU, Kai ,  SHAO, Lixin ,  VRUBLIAUSKAS, Darius ,  WU, Liangxing ,  YAO, Wenqing ,  YUE, Eddy, W.

IPC: C07D471/20 ,  C07D471/22 ,  C07D491/22 ,  C07D519/00 ,  C07B59/00 ,  A61P35/00 ,  A61P35/02 ,  A61K31/438

Abstract: The present application provides spirocyclic lactam compounds of Formula I that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

公开(公告)号：WO2017120194A1

公开(公告)日：2017-07-13

申请号：PCT/US2017/012135

申请日：2017-01-04

Applicant: INCYTE CORPORATION

Inventor： SPARKS, Richard B. ,  SHEPARD, Stacey ,  COMBS, Andrew P. ,  BUESKING, Andrew W. ,  SHAO, Lixin ,  WANG, Haisheng ,  FALAHATPISHEH, Nikoo

IPC: C07D401/14 ,  C07D403/14 ,  A61K31/506 ,  A61P35/00

CPC classification number: C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107

Abstract: The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Abstract translation: 本公开提供了调节磷酸肌醇3激酶-γ（PI3Kγ）活性并用于治疗与下列药物活性有关的疾病的式I化合物或其药学上可接受的盐： 包括例如自身免疫疾病，癌症，心血管疾病和神经退行性疾病的PI3Kγ。

公开(公告)号：WO2015164480A1

公开(公告)日：2015-10-29

申请号：PCT/US2015/027047

申请日：2015-04-22

Applicant: INCYTE CORPORATION

Inventor： COMBS, Andrew, P. ,  MADUSKUIE, Thomas, P., Jr. ,  FALAHATPISHEH, Nikoo

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00 ,  A61P37/00 ,  A61P31/00 ,  A61P33/00 ,  A61P25/28 ,  A61P11/06 ,  A61P9/10 ,  A61P25/24

CPC classification number: C07D471/04 ,  A61K31/546

Abstract: The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

Abstract translation: 本发明涉及作为BET蛋白如BRD2，BRD3，BRD4和BRD-t的抑制剂的取代吡咯并吡啶酮和取代的吡唑并吡啶酮，可用于治疗诸如癌症的疾病。

公开(公告)号：WO2007070514A1

公开(公告)日：2007-06-21

申请号：PCT/US2006/047369

申请日：2006-12-12

Applicant: INCYTE CORPORATION ,  RODGERS, James D. ,  SHEPARD, Stacey ,  MADUSKUIE, Thomas P. ,  WANG, Haisheng ,  FALAHATPISHEH, Nikoo ,  RAFALSKI, Maria ,  ARVANITIS, Argyrios G. ,  STORACE, Louis ,  JALLURI, Ravi Kumar ,  FRIDMAN, Jordan S. ,  VADDI, Krishna

Inventor： RODGERS, James D. ,  SHEPARD, Stacey ,  MADUSKUIE, Thomas P. ,  WANG, Haisheng ,  FALAHATPISHEH, Nikoo ,  RAFALSKI, Maria ,  ARVANITIS, Argyrios G. ,  STORACE, Louis ,  JALLURI, Ravi Kumar ,  FRIDMAN, Jordan S. ,  VADDI, Krishna

IPC: C07D471/04 ,  C07D487/04 ,  A61K31/395 ,  A61P17/00 ,  A61P35/00 ,  A61P37/00

CPC classification number: A61K31/519 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/20 ,  A61K31/573 ,  A61K45/06 ,  C07B59/002 ,  C07B2200/05 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines (I) and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

Abstract translation: 本发明提供调节Janus激酶活性的杂芳基取代的吡咯并[2,3-b]吡啶（I）和杂芳基取代的吡咯并[2,3-b]嘧啶，并且可用于治疗与Janus的活性有关的疾病 激酶包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。