公开(公告)号：WO2023012334A1

公开(公告)日：2023-02-09

申请号：PCT/EP2022/072088

申请日：2022-08-05

Applicant: INNOVACELL AG

Inventor： THURNER, Marco ,  MARKSTEINER, Rainer

IPC: A61K35/34 ,  A61P21/00

Abstract: The present invention relates to myogenic progenitor cells (MFCs) for use in a method for the prevention and/or treatment of anal incontinence in a subject, wherein said subject is at risk to develop anal incontinence or suffers from anal incontinence for 20 years or less than 20 years, more preferably for about 6 months to about 20 years or for about 6 months to about 10 years. The present invention also refers to a pharmaceutical composition comprising MFCs and a pharmaceutical acceptable excipient and/or carrier for use in a method for the prevention and/or treatment of anal incontinence according to the present invention.

公开(公告)号：WO2021255016A1

公开(公告)日：2021-12-23

申请号：PCT/EP2021/066086

申请日：2021-06-15

Applicant: INNOVACELL AG

Inventor： CERMAK, Craig Joseph ,  MARKSTEINER, Rainer ,  THURNER, Marco

IPC: A61B8/08 ,  A61B8/12 ,  A61B8/00 ,  A61B10/00 ,  A61B17/34 ,  A61M5/32 ,  A61B17/3403 ,  A61B2017/3405 ,  A61B2017/3413 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/4218 ,  A61B8/4455 ,  A61M5/427 ,  A61M5/46

Abstract: A guidance device is provided for facilitating the placement of a puncture device (a needle) at a defined position relative to an ultrasound probe. The guidance device provides additional support of a needle tip near the needle injection site to maintain a selected path throughout an injection. The additional support is automatically retracted for simple disposal with the used syringe after an injection. The guidance device minimizes contact of soiled components and enables syringe insertion, alignment, and removal for multiple different injections without removal of an ultrasound probe from the patient. More particularly, this invention relates to a puncture device guide, comprising: an adapter configured to fixedly attach to an ultrasound probe; a syringe holder assembly configured to slidingly attach to the adapter and receive a syringe therein; wherein the syringe holder assembly is configured to slide on probe adapter in an axial direction relative to the ultrasound probe; wherein the syringe holder assembly is configured to allow for selective adjustment of a radial distance for a path of a needle of the syringe relative to the ultrasound probe; wherein the adapter includes a tip guide to selectively align a distal end of the needle with the radial distance for the path; and wherein, when the ultrasound probe is inserted into a patient, the syringe assembly is configured to slide forward on the adapter to insert the needle past the tip guide into a patient. The present invention further relates to a method of performing an injection, in particular by using a puncture device guide according to the present invention and to a guide plate configured to be used with a puncture device guide according to the present invention.