公开(公告)号：WO9937274A3

公开(公告)日：1999-09-30

申请号：PCT/US9901385

申请日：1999-01-21

Applicant: INT FLORA TECHNOLOGIES LTD

Inventor： ARQUETTE DEMETRIOS JAMES G ,  BROWN JIM ,  REINHARDT JOHN

IPC: A61K8/00 ,  A61K8/02 ,  A61K8/04 ,  A61K8/19 ,  A61K8/29 ,  A61K8/30 ,  A61K8/34 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/41 ,  A61K8/44 ,  A61K8/49 ,  A61K8/64 ,  A61K8/66 ,  A61K8/67 ,  A61K8/81 ,  A61K8/86 ,  A61K8/891 ,  A61K8/894 ,  A61K8/92 ,  A61K8/96 ,  A61K8/97 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q1/12 ,  A61Q17/02 ,  A61Q17/04 ,  A61Q19/00 ,  C07C67/03 ,  C07C69/533 ,  A61K7/48

CPC classification number: C07C69/533 ,  A61K8/025 ,  A61K8/19 ,  A61K8/29 ,  A61K8/342 ,  A61K8/345 ,  A61K8/361 ,  A61K8/365 ,  A61K8/37 ,  A61K8/375 ,  A61K8/41 ,  A61K8/44 ,  A61K8/4946 ,  A61K8/671 ,  A61K8/675 ,  A61K8/678 ,  A61K8/8152 ,  A61K8/86 ,  A61K8/891 ,  A61K8/894 ,  A61K8/922 ,  A61K2800/652 ,  A61K2800/872 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/06 ,  A61Q1/10 ,  A61Q17/04 ,  A61Q19/00 ,  C07C67/03 ,  Y10S514/844 ,  Y10S514/873

Abstract: Dry-feel emollient composition additives comprising jojoba oil based esters have use in personal care, cosmetic, cosmeceutical and pharmaceutical products. The composition is essentially solid at room temperature, can be provided in various shapes and sizes (especially as particulates such as spheres), and can be produced from combinations of fatty alcohols, isopropyl esters and wax esters obtained from the oil contained in the seed of the jojoba plant (Simmondsia chinensis), jojoba oil. These new compositions also increase the range of applications for cosmetic compositions through an emollient that is more polar and hydrophilic than is found in jojoba oils (which may also be referred to in the art as jojoba wax esters). The compositions comprising fatty alcohols, isopropyl esters and jojoba wax esters (jojoba oil) may be obtained by a novel process of a base catalyzed alcoholysis reaction between jojoba oil and an alcohol, such as isopropyl alcohol. These esters, whether exclusively jojoba esters or when combined with other carrier and vehicle components (including other emollients or binders) can form excellent carrier and vehicle or delivery compositions for use in the cosmetic, personal care and/or pharmaceutical field, including the cosmeceutical field where cosmetic compositions also provide pharmaceutical or other therapeutic benefits. Typical materials with which the jojoba esters may be blended in accordance with the practice of the present invention include, but are not limited to, cosmetic oils and waxes, both natural and synthetic, including hydrogenated or partially hydrogenated oils, silicone oils, mineral oils, long chain esters, vitamins (especially vitamin E), long chain fatty acids, alcohols, cosmeceuticals, pigments, botanical extracts, esters and ethers, dimers, trimers, oligomers, and polymers, and the like. These blended compositions may of course be combined with the active ingredients intended to be delivered by the compositions used in the present invention. The proportions of the jojoba esters should be chosen to provide the dry-feel to the composition which is highly desired. This will usually require at least 10 %, often at least 20 %, preferably at least 30 %, more preferably at least 40 or 50 % by weight, and most preferably at least 60, at least 70, at least 80, and at least 90 % (up to 100 % by weight) by weight of carrier material (excluding solvent and actives) in the composition.

Abstract translation: 包含霍霍巴油基酯的干性润肤组合物添加剂可用于个人护理，化妆品，药​​妆和医药产品。 组合物在室温下基本上是固体，可以以各种形状和大小（特别是颗粒如球体）提供，并且可以由脂肪醇，异丙酯和蜡酯的组合制备，所述脂肪醇，异丙酯和蜡酯由 荷荷巴植物（Simmondsia chinensis），霍霍巴油。 这些新的组合物还通过柔软剂增加了化妆品组合物的应用范围，该润肤剂比在霍霍巴油（在本领域中也称为霍霍巴蜡酯）中所发现的更具极性和亲水性。 包含脂肪醇，异丙酯和霍霍巴蜡酯（荷荷巴油）的组合物可以通过在霍霍巴油和醇如异丙醇之间的碱催化的醇解反应的新方法获得。 这些酯，无论是单独的霍霍巴酯，还是与其他载体和载体组分（包括其它润肤剂或粘合剂）组合可以形成用于化妆品，个人护理和/或药物领域的优秀载体和载体或递送组合物，包括药妆领域 其中化妆品组合物还提供药物或其它治疗益处。 根据本发明的实践可以混合霍霍巴酯的典型材料包括但不限于天然和合成的化妆油和蜡，包括氢化或部分氢化的油，硅油，矿物油， 长链酯，维生素（特别是维生素E），长链脂肪酸，醇，药妆，色素，植物提取物，酯和醚，二聚体，三聚体，低聚物和聚合物等。 这些共混组合物当然可以与预期由本发明使用的组合物递送的活性成分组合。 应选择荷荷巴酯的比例以提供高度期望的组合物的干燥感觉。 这通常需要至少10％，通常至少20％，优选至少30％，更优选至少40或50％，最优选至少60，至少70，至少80，并且至少 90％（高达100重量％）的载体材料（不包括溶剂和活性物质）在组合物中。